PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23302639-6	2013	FK886 inhibited substance P (3.2 nM)-induced inositol phosphate formation in human NK(1) receptor-expressing CHO cells (IC(50)=1.4 nM) without stimulating NK(1) receptors.	Inositol Phosphates	45-63	tachykinin receptor 1	Homo sapiens	83-97	
11316660-0	2001	NK1 receptor stimulation causes contraction and inositol phosphate increase in medium-size human isolated bronchi.	Inositol Phosphates	48-66	tachykinin receptor 1	Homo sapiens	0-12	
10908293-4	2000	In contrast to the similarly mutated beta(2)-adrenergic receptor, signal transduction-i.e., inositol phosphate turnover-could be stimulated by both Zn(2+) and by the natural agonist, Substance P in the mutated NK(1) receptor.	Inositol Phosphates	92-110	tachykinin receptor 1	Homo sapiens	210-224	
11090877-7	2000	When applied to CHO cells expressing the human NK1R, a synthetic extended 17-amino-acid peptide (denoted CDR2L) corresponding to this VL region inhibited the high-affinity binding of radiolabeled SP and antagonized the SP-induced inositol phosphate production.	Inositol Phosphates	230-248	tachykinin receptor 1	Homo sapiens	47-51	
8627566-3	1996	In vitro functional assays are consistent with potent competitive antagonism of substance P-(SP) or neurokinin A-(NKA) induced [3H]-inositol phosphate accumulation in NK-1 or NK-2 monoreceptor cell lines with pA2 values of 8.19 and 8.67, respectively.	Inositol Phosphates	132-150	tachykinin receptor 1	Homo sapiens	167-171	
9022979-5	1996	NK-1 agonists bind to human NK-1 receptor and activate the production of both inositol phosphates and cyclic AMP.	Inositol Phosphates	78-97	tachykinin receptor 1	Homo sapiens	0-4	
1378485-1	1992	The activation of NK1 receptors on U373 MG human astrocytoma cells by substance P (SP) and related tachykinins was accompanied by an increase in taurine release and an accumulation of inositol phosphates.	Inositol Phosphates	184-203	tachykinin receptor 1	Homo sapiens	18-21	
7679727-8	1993	A good correlation was found when the abilities of NK1 receptor agonists for stimulating inositol phosphate production and for inhibiting [3H]substance P binding were compared.	Inositol Phosphates	89-107	tachykinin receptor 1	Homo sapiens	51-63	
7679031-2	1993	The potency of the non-peptide antagonists CP-96,345 and RP 67580 on NK1 receptor-stimulated [3H]-inositol phosphate accumulation in cell lines or tissue from three different species has been examined.	Inositol Phosphates	98-116	tachykinin receptor 1	Homo sapiens	69-81	
1378485-9	1992	These findings are consistent with the hypothesis that an activation of NK1 receptors on U373 MG cells results in the release of inositol phosphates and activation of PKC, which in turn may regulate the release of taurine.	Inositol Phosphates	129-148	tachykinin receptor 1	Homo sapiens	72-75	
1719914-0	1991	Role of inositol phosphates in the actions of substance P on NK1 receptors in exocrine gland cells.	Inositol Phosphates	8-27	tachykinin receptor 1	Homo sapiens	61-64