PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10197974-9 1999 All fluorescent analogues were antagonists as shown by the inhibition of vasopressin induced inositol phosphate accumulation. Inositol Phosphates 93-111 arginine vasopressin Homo sapiens 73-84 9357056-8 1997 Vasopressin action on NCI H82 cells resulted in a substantial rise in the levels of total inositol phosphates. Inositol Phosphates 90-109 arginine vasopressin Homo sapiens 0-11 9164840-9 1997 Vasopressin and histamine, both activators of the inositol phosphate/diacylglycerol phosphate pathway in non-pigmented ciliary epithelial cells, inhibited CNP stimulation of guanylate cyclase (NPR-B) and 125I-ANP binding (NPR-C) by 30-38%. Inositol Phosphates 50-68 arginine vasopressin Homo sapiens 0-11 7867583-4 1995 Vasopressin also stimulated an increase in intracellular calcium through at least two distinct mechanisms: the mobilization of intracellular pools via vasopressin-stimulated inositol phosphate accumulation and the activation of calcium influx. Inositol Phosphates 174-192 arginine vasopressin Homo sapiens 0-11 7867583-4 1995 Vasopressin also stimulated an increase in intracellular calcium through at least two distinct mechanisms: the mobilization of intracellular pools via vasopressin-stimulated inositol phosphate accumulation and the activation of calcium influx. Inositol Phosphates 174-192 arginine vasopressin Homo sapiens 151-162 7867583-6 1995 In fasciculata cells, vasopressin and angiotensin-II were also able to stimulate cortisol secretion and inositol phosphate accumulation. Inositol Phosphates 104-122 arginine vasopressin Homo sapiens 22-33 1348499-2 1992 Maximal stimulation of inositol phosphate formation by vasopressin (approximately 3-fold), carbachol (approximately 2-fold) and histamine (approximately 5-fold) was observed only after cells had been confluent for at least six days. Inositol Phosphates 23-41 arginine vasopressin Homo sapiens 55-66 1348499-7 1992 The data suggest that the muscarinic receptor on human NPE cells is the M3 subtype, whereas the vasopressin receptor, as defined by its linkage to the inositol phosphate/diacylglycerol pathway, is the V1 subtype. Inositol Phosphates 151-169 arginine vasopressin Homo sapiens 96-107 2288702-1 1990 We have investigated the metabolic interrelationships of the major inositol phosphates in vasopressin-stimulated WRK 1 mammary tumor cells which were labeled to equilibrium with [14C]inositol and briefly, just prior to stimulation, with [3H]inositol. Inositol Phosphates 67-86 arginine vasopressin Homo sapiens 90-101 1665120-8 1991 These data suggest that RPE cells possess V1 AVP receptors coupled to calcium mobilization and inositol phosphate metabolism. Inositol Phosphates 95-113 arginine vasopressin Homo sapiens 45-48 2536741-4 1989 When platelets were stimulated with vasopressin in the presence of the compound, protein kinase C activity was markedly increased; the formation of inositol phosphates, the increase in intracellular Ca2+ and shape-change reaction were antagonized while the vasopressin-induced polyphosphoinositide synthesis was amplified, and this in a distinct inositolphospholipid pool. Inositol Phosphates 148-167 arginine vasopressin Homo sapiens 36-47 2548484-0 1989 Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells. Inositol Phosphates 69-87 arginine vasopressin Homo sapiens 49-60 2548484-1 1989 The accumulation of inositol phosphates in WRK 1 cells, stimulated with a range of vasopressin concentrations, was diminished by prior exposure to cholera toxin or forskolin, whilst that observed in the presence of maximal concentrations of the hormone was enhanced in pertussis-toxin-treated cells. Inositol Phosphates 20-39 arginine vasopressin Homo sapiens 83-94 2548484-7 1989 The kinetics for the loss of this binding capacity following cholera-toxin treatment were very similar to those describing the diminution of vasopressin-stimulated inositol phosphate accumulation in the same cells. Inositol Phosphates 164-182 arginine vasopressin Homo sapiens 141-152 2543367-1 1989 Incubation of L6 skeletal myoblasts for 16 h with cholera toxin but not with pertussis toxin, led to the inhibition of inositol phosphate generation induced by subsequent exposure to vasopressin. Inositol Phosphates 119-137 arginine vasopressin Homo sapiens 183-194 2543367-5 1989 The cholera-toxin-mediated inhibition of vasopressin-stimulated inositol phosphate generation could be mimicked by both forskolin and dibutyryl cyclic AMP, but not by the separated subunits of the toxin. Inositol Phosphates 64-82 arginine vasopressin Homo sapiens 41-52 2543367-6 1989 Receptor-binding studies demonstrated that the inhibition of agonist-stimulated inositol phosphate generation was accompanied by a decrease in cell-surface vasopressin-binding sites, with no effect on the affinity of these for the hormone. Inositol Phosphates 80-98 arginine vasopressin Homo sapiens 156-167 2545648-4 1989 The accumulation of inositol phosphates in response to several agonists (carbachol, 1 mM; ATP, 100 microM; arginine vasopressin, 1 microM; and phenylephrine, 100 microM) was determined for times ranging from 5 sec to 15 min. Inositol Phosphates 20-39 arginine vasopressin Homo sapiens 116-127 2785108-4 1989 We show that (i) MA-10 cells express a hormone-sensitive inositol phosphate/diacylglycerol pathway that can be stimulated with arginine vasopressin (AVP), (ii) mEGF does not activate this pathway, and (iii) activation of this pathway with arginine vasopressin does not mimic the biological actions of mEGF. Inositol Phosphates 57-75 arginine vasopressin Homo sapiens 136-147 2525909-3 1989 In addition to V2-vasopressin receptors that mediate hormonal signals by adenylate cyclase activation and cAMP release, in V1-vasopressin-receptors extracellular vasopressin signal is mediated by the breakdown of inositol phosphates and the release of inositol-triphosphates and diacylglycerol. Inositol Phosphates 213-232 arginine vasopressin Homo sapiens 126-137 2525909-3 1989 In addition to V2-vasopressin receptors that mediate hormonal signals by adenylate cyclase activation and cAMP release, in V1-vasopressin-receptors extracellular vasopressin signal is mediated by the breakdown of inositol phosphates and the release of inositol-triphosphates and diacylglycerol. Inositol Phosphates 213-232 arginine vasopressin Homo sapiens 126-137 2522448-1 1989 Arginine vasopressin (AVP)-induced formation of inositol phosphates and increased calcium efflux in smooth muscle cells (A-10) were inhibited by short term treatment with phorbol 12,13-dibutyrate (PDBu), an activator of protein kinase C (Ca2+/phospholipid-dependent protein kinase) (Aiyar, N., Nambi, P., Whitman, M., Stassen, F. L., and Crooke, S. T. (1987) Mol. Inositol Phosphates 48-67 arginine vasopressin Homo sapiens 9-20 2543821-3 1989 It was shown that in EC the release of inositol phosphates can be stimulated by histamine, thrombin, serotonin, acetylcholine, carbachol, bradykinin, vasopressin, angiotensin II, platelet-activating factor (PAF), the thromboxane A2 mimetic, U46619, and prostaglandin E2. Inositol Phosphates 39-58 arginine vasopressin Homo sapiens 150-161 2820960-8 1987 On the other hand, vasopressin treatment appears to decrease incorporation of [3H]inositol into the hormone-sensitive pool, probably by shifting the equilibrium between phosphoinositides and inositol phosphates, since the decrease in radioactivity observed in the phosphoinositides is equaled by the increase observed in that in the inositol phosphates. Inositol Phosphates 191-210 arginine vasopressin Homo sapiens 19-30 3138102-12 1988 Oxytocin and vasopressin are hormonal activators of this system in these cells, as demonstrated by their effects on inositol phosphate turnover and [Ca2+]i. Inositol Phosphates 116-134 arginine vasopressin Homo sapiens 13-24 3346337-1 1988 Mitogenic stimulation of quiescent human fibroblasts (HSWP) with serum or a mixture of growth factors (consisting of vasopressin, bradykinin, EGF, and insulin) stimulates the release of inositol phosphates, mobilization of intracellular Ca, activation of Na/H exchange and subsequent incorporation of [3H]-thymidine. Inositol Phosphates 186-205 arginine vasopressin Homo sapiens 117-128 2820960-8 1987 On the other hand, vasopressin treatment appears to decrease incorporation of [3H]inositol into the hormone-sensitive pool, probably by shifting the equilibrium between phosphoinositides and inositol phosphates, since the decrease in radioactivity observed in the phosphoinositides is equaled by the increase observed in that in the inositol phosphates. Inositol Phosphates 333-352 arginine vasopressin Homo sapiens 19-30 3113428-0 1987 A pertussis/cholera toxin sensitive G-protein may mediate vasopressin-induced inositol phosphate formation in smooth muscle cell. Inositol Phosphates 78-96 arginine vasopressin Homo sapiens 58-69 3113428-3 1987 Protein kinase C activator, phorbol ester blocks the AVP effect on the production of inositol phosphates, suggesting that AVP induced phospholipase C (PLC) activation is under the negative feedback regulation by diacylglycerol production. Inositol Phosphates 85-104 arginine vasopressin Homo sapiens 53-56 3113428-3 1987 Protein kinase C activator, phorbol ester blocks the AVP effect on the production of inositol phosphates, suggesting that AVP induced phospholipase C (PLC) activation is under the negative feedback regulation by diacylglycerol production. Inositol Phosphates 85-104 arginine vasopressin Homo sapiens 122-125 3113428-4 1987 Prolonged overnight treatment with either pertussis toxin and cholera toxin resulted partial inhibition of AVP-induced production of inositol phosphates. Inositol Phosphates 133-152 arginine vasopressin Homo sapiens 107-110 3827839-0 1986 Stimulation, by vasopressin and other agonists, of inositol-lipid breakdown and inositol phosphate accumulation in WRK 1 cells. Inositol Phosphates 80-98 arginine vasopressin Homo sapiens 16-27 3827839-10 1986 The effects of sub-optimal concentrations of bradykinin and vasopressin upon inositol phosphate accumulation were additive, but those of optimal concentrations of the hormones were not. Inositol Phosphates 77-95 arginine vasopressin Homo sapiens 60-71 3779039-0 1986 Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidua cells. Inositol Phosphates 35-53 arginine vasopressin Homo sapiens 13-24 3026353-0 1986 The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes. Inositol Phosphates 76-95 arginine vasopressin Homo sapiens 99-110 3026353-10 1986 The vasopressin-stimulated accumulation of inositol phosphates in the presence of 10 mM-Li+ was abolished by a V1-vasopressin antagonist. Inositol Phosphates 43-62 arginine vasopressin Homo sapiens 4-15 3026353-10 1986 The vasopressin-stimulated accumulation of inositol phosphates in the presence of 10 mM-Li+ was abolished by a V1-vasopressin antagonist. Inositol Phosphates 43-62 arginine vasopressin Homo sapiens 114-125 3770193-2 1986 The production of inositol phosphates in response to other platelet agonists (vasopressin, platelet activating factor, prostaglandin endoperoxide analogs and collagen) is not inhibited by neomycin, even at a concentration of 2 mM. Inositol Phosphates 18-37 arginine vasopressin Homo sapiens 78-117 3015563-2 1986 In the present study, we demonstrate that vasopressin (VP) stimulates the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of glomerulosa as well as fasciculata cells 5- to 8-fold over the corresponding basal values. Inositol Phosphates 87-109 arginine vasopressin Homo sapiens 42-53 3015563-2 1986 In the present study, we demonstrate that vasopressin (VP) stimulates the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of glomerulosa as well as fasciculata cells 5- to 8-fold over the corresponding basal values. Inositol Phosphates 87-109 arginine vasopressin Homo sapiens 55-57 3015563-6 1986 We conclude that VP- and ATII-induced formation of inositol phosphates may represent an early step in the action of these peptides on adrenal cells. Inositol Phosphates 51-70 arginine vasopressin Homo sapiens 17-19 3015563-9 1986 On fasciculata cells, VP induces a significant increase in the formation of inositol phosphates in spite of the absence of a known biological function in these cells. Inositol Phosphates 76-95 arginine vasopressin Homo sapiens 22-24 3699163-2 1986 In the presence of LiCl (10 mM), four agonists [serotonin, angiotensin, (arginine) vasopressin and noradrenaline] were found to stimulate the formation of inositol phosphates in a dose-dependent manner. Inositol Phosphates 155-174 arginine vasopressin Homo sapiens 83-94 3943628-2 1986 Vasopressin stimulates the liberation of labelled inositol phosphate in partially purified plasma membranes prepared from myo-[3H]inositol prelabelled WRK1 cells. Inositol Phosphates 50-68 arginine vasopressin Homo sapiens 0-11 6435618-0 1984 Serum, bradykinin and vasopressin stimulate release of inositol phosphates from human fibroblasts. Inositol Phosphates 55-74 arginine vasopressin Homo sapiens 22-33 6435618-1 1984 The mitogens serum, vasopressin and bradykinin stimulate a significant rise in the inositol phosphate content of cultured human fibroblasts within 10 seconds, while serum- and bradykinin-stimulated arachidonic acid release does not occur until after 30 seconds. Inositol Phosphates 83-101 arginine vasopressin Homo sapiens 20-31 3006664-1 1986 The activation of platelet V1-receptors by vasopressin (0.01-1 microM) induces the rapid formation of inositol phosphates, 1,2-diacylglycerol and phosphatidic acid, indicating inositol phospholipid hydrolysis by phospholipase C. Vasopressin immediately induces the formation of inositol bisphosphate and inositol trisphosphate. Inositol Phosphates 102-121 arginine vasopressin Homo sapiens 43-54 2994663-2 1985 [Arg 8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. Inositol Phosphates 75-94 arginine vasopressin Homo sapiens 7-18