PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12101219-6	2002	The expression of the GRK2 C-terminal domain to block membrane translocation of endogenous GRK2 increases mGluR1a-866Delta- and mGluR1b-stimulated inositol phosphate formation, presumably by blocking membrane translocation of GRK2.	Inositol Phosphates	147-165	glutamate metabotropic receptor 1	Homo sapiens	106-112	
20180987-6	2010	Pyk2 overexpression in HEK293 results in attenuated basal and agonist-stimulated inositol phosphate formation in mGluR1 expressing cells and involves a mechanism whereby Pyk2 displaces Galphaq/11 from the receptor.	Inositol Phosphates	81-99	glutamate metabotropic receptor 1	Homo sapiens	113-119	
20644995-2	2010	Overactivation of group I metabotropic glutamate receptors (mGluRs), which include mGluR1 as well as mGluR5 and are coupled via phospholipase C to the inositol phosphate pathway, is found to be involved in mutant htt-mediated neurotoxicity.	Inositol Phosphates	151-169	glutamate metabotropic receptor 1	Homo sapiens	60-66	
20644995-2	2010	Overactivation of group I metabotropic glutamate receptors (mGluRs), which include mGluR1 as well as mGluR5 and are coupled via phospholipase C to the inositol phosphate pathway, is found to be involved in mutant htt-mediated neurotoxicity.	Inositol Phosphates	151-169	glutamate metabotropic receptor 1	Homo sapiens	83-89	
12101219-5	2002	However, mGluR1a-866Delta- and mGluR1b-stimulated inositol phosphate formation is attenuated following GRK2 expression.	Inositol Phosphates	50-68	glutamate metabotropic receptor 1	Homo sapiens	9-15	
8093260-6	1993	The dose response of quisqualate for the reduction in mGluR1 mRNA is consistent with that for inositol phosphate formation stimulated through the cloned mGluR1.	Inositol Phosphates	94-112	glutamate metabotropic receptor 1	Homo sapiens	153-159	
7981634-4	1994	Transient transfection of HEK-293 cells with mGluR1a, but not the mGluR1T cDNA, resulted in a significant increase in inositol phosphate (IP) formation in absence of any mGluR agonists.	Inositol Phosphates	118-136	glutamate metabotropic receptor 1	Homo sapiens	45-51	
7981634-4	1994	Transient transfection of HEK-293 cells with mGluR1a, but not the mGluR1T cDNA, resulted in a significant increase in inositol phosphate (IP) formation in absence of any mGluR agonists.	Inositol Phosphates	138-140	glutamate metabotropic receptor 1	Homo sapiens	45-51	
8369491-1	1993	The expression of metabotropic glutamate receptors (mGluRs) in primary cultures of cerebellar granule neurones can be: (i) modulated by the degree of depolarization during the culture period, rendering neurones differently sensitive to agonist-stimulated inositol phosphate (IP) hydrolysis; (ii) down-regulated by specific mGluR agonists.	Inositol Phosphates	255-273	glutamate metabotropic receptor 1	Homo sapiens	52-58	
8369491-1	1993	The expression of metabotropic glutamate receptors (mGluRs) in primary cultures of cerebellar granule neurones can be: (i) modulated by the degree of depolarization during the culture period, rendering neurones differently sensitive to agonist-stimulated inositol phosphate (IP) hydrolysis; (ii) down-regulated by specific mGluR agonists.	Inositol Phosphates	275-277	glutamate metabotropic receptor 1	Homo sapiens	52-58	
11961129-6	2002	Similarly, inositol phosphate production after glutamate-induced activation of mGluR1a and mGluR1c was increased after PKC inhibition, whereas glutamate-induced mGluR1b stimulation was unaffected.	Inositol Phosphates	11-29	glutamate metabotropic receptor 1	Homo sapiens	79-85