PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8885247-0	1996	The C-terminal third of the human luteinizing hormone (LH) receptor is important for inositol phosphate release: analysis using chimeric human LH/follicle-stimulating hormone receptors.	Inositol Phosphates	85-103	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	34-67	
19010824-2	2008	Activated LHR initiates second messenger responses, including cyclic AMP (cAMP) and inositol phosphate.	Inositol Phosphates	84-102	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	10-13	
7527413-8	1994	The mutant LH/CGR, created by site-directed mutagenesis in vitro, exhibited constitutively higher cAMP levels in transfected COS-7 cells than the wild-type LH/CGR, as described previously; however, basal inositol phosphate levels were not increased by transfection with complementary DNA for the mutant receptor.	Inositol Phosphates	204-222	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	11-17	
21490077-7	2011	D578H-LHR displayed a constitutively increased but noninducible production of cAMP, led to a very high production of inositol phosphates, and induced a slight phosphorylation of p44/42 MAPK in the absence of human chorionic gonadotropin.	Inositol Phosphates	117-136	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	6-9	
1311310-10	1992	We conclude that the LH receptor has the capability of activating two intracellular signaling pathways: one leading to stimulation of adenylyl cyclase and resulting in increases in cAMP and a second leading to stimulation of phospholipase C and resulting in formation of inositol phosphates and elevations in [Ca2+]i.	Inositol Phosphates	271-290	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	21-32	
18313839-4	2008	When expressed in immature rat granulosa cells the hLHR stimulates cAMP and inositol phosphate accumulation, transactivates the epidermal growth factor receptor (EGFR), elicits a transient increase in Akt phosphorylation, and a sustained increase in ERK1/2 phosphorylation but aromatase expression is not enhanced.	Inositol Phosphates	76-94	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	51-55	
17412805-4	2007	Infection with adenovirus coding for the human LHR (hLHR) allowed for expression of the hLHR at a density of approximately 25,000 receptors per cell and allowed the cells to respond to hCG with increases in cAMP and inositol phosphate accumulation, steroid biosynthesis, and the phosphorylation of ERK1/2.	Inositol Phosphates	216-234	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	47-50	
17412805-4	2007	Infection with adenovirus coding for the human LHR (hLHR) allowed for expression of the hLHR at a density of approximately 25,000 receptors per cell and allowed the cells to respond to hCG with increases in cAMP and inositol phosphate accumulation, steroid biosynthesis, and the phosphorylation of ERK1/2.	Inositol Phosphates	216-234	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	52-56	
17412805-4	2007	Infection with adenovirus coding for the human LHR (hLHR) allowed for expression of the hLHR at a density of approximately 25,000 receptors per cell and allowed the cells to respond to hCG with increases in cAMP and inositol phosphate accumulation, steroid biosynthesis, and the phosphorylation of ERK1/2.	Inositol Phosphates	216-234	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	88-92	
15919743-2	2005	Increasing amounts of Ad-hLHR, used at a multiplicity of infection (MOI) of 20 or 200 viable viral particles/cell, increased human chorionic gonadotropin (hCG) binding and hCG-induced cAMP and Akt phosphorylation, but inositol phosphates only increased in response to hCG in cells infected with 200 MOI Ad-hLHR.	Inositol Phosphates	218-237	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	25-29	
11861529-4	2002	We show that the recombinant hLHR can be expressed at variable densities in MA-10 cells and that it can stimulate cAMP and steroid synthesis as well as activate the inositol phosphate and MAPK cascades.	Inositol Phosphates	165-183	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	29-33	
11861529-5	2002	We also show that two naturally occurring mutants of the hLHR associated with Leydig cell hyperplasia and one mutant associated with Leydig cell adenomas are constitutively active when assayed for activation of cAMP, inositol phosphate, progesterone, and MAPK.	Inositol Phosphates	217-235	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	57-61	
11394209-10	2001	As with LH-R, activation of FSH-R by FSH is associated with activation of a G protein-coupled receptor family that mediates the cAMP and inositol phosphate signaling pathways.	Inositol Phosphates	137-155	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	8-12