PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9654124-3 1998 In parallel with the decrease in receptor expression, a progressive decrease in angiotensin II-induced inositol phosphate responses was observed. Inositol Phosphates 103-121 angiotensinogen Rattus norvegicus 80-94 9146895-3 1997 In order to characterize further these effects we studied, in neonatal rat ventricular cardiomyocytes, the effects of several endothelin-receptor antagonists and the AT1-receptor antagonist losartan on AII- and endothelin-induced inositol phosphate (IP)-formation (assessed as accumulation of total [3H]-IPs in myo-[3H]-inositol prelabelled cells) and increase in rate of protein synthesis (assessed as [3H]-phenylalanine incorporation). Inositol Phosphates 230-248 angiotensinogen Rattus norvegicus 202-205 9325274-3 1997 These chimeric receptors were stably expressed in Chinese hamster ovary cells, and their pharmacological and functional properties were characterized, including AngII-induced inositol phosphate and cyclic AMP (cAMP) productions, [3H]thymidine incorporation into DNA, and internalization. Inositol Phosphates 175-193 angiotensinogen Rattus norvegicus 161-166 9650856-7 1998 Furthermore, some of these substitutions, which impaired the inositol phosphate accumulation in response to angiotensin II, also impaired the response to L-162,313. Inositol Phosphates 61-79 angiotensinogen Rattus norvegicus 108-122 9231781-6 1997 These associations and plasma membrane redistribution under Ang II stimulation indicate that microfilaments and microtubules are both involved in phospholipase C activation and inositol phosphate production. Inositol Phosphates 177-195 angiotensinogen Rattus norvegicus 60-66 8816747-3 1996 Nonpolar replacements for Leu-222 yielded functionally intact AT1 receptors, while polar or charged residues caused progressive impairment of Ang II-induced inositol phosphate generation. Inositol Phosphates 157-175 angiotensinogen Rattus norvegicus 142-148 9218128-5 1997 Similarly, cold preservation decreased the accumulation of cyclic AMP induced by glucagon and the effects of norepinephrine (plus propranolol), vasopressin and angiotensin II on the production of inositol phosphates. Inositol Phosphates 196-215 angiotensinogen Rattus norvegicus 160-174 9213202-1 1997 The effect of angiotensin II (Ang II) on inositol phosphate (IP) production and atrial natriuretic peptide (ANP) release was studied in sliced rat atrial tissue. Inositol Phosphates 41-59 angiotensinogen Rattus norvegicus 14-28 9213202-1 1997 The effect of angiotensin II (Ang II) on inositol phosphate (IP) production and atrial natriuretic peptide (ANP) release was studied in sliced rat atrial tissue. Inositol Phosphates 41-59 angiotensinogen Rattus norvegicus 30-36 9213202-1 1997 The effect of angiotensin II (Ang II) on inositol phosphate (IP) production and atrial natriuretic peptide (ANP) release was studied in sliced rat atrial tissue. Inositol Phosphates 61-63 angiotensinogen Rattus norvegicus 30-36 9152965-0 1997 Effects of age and gender on the AII-induced stimulation of prolactin release and inositol phosphate accumulation in rat anterior pituitary cells in vitro. Inositol Phosphates 82-100 angiotensinogen Rattus norvegicus 33-36 9097077-6 1997 PLC activity was coupled to an AT1 receptor in both medullary and cerebellar astrocytes, as demonstrated by the inhibition of Ang II-activation of inositol phosphate release by the AT1 antagonist losartan. Inositol Phosphates 147-165 angiotensinogen Rattus norvegicus 126-132 8613262-6 1996 Dexamethasone also markedly inhibited Ang II-dependent inositol phosphate accumulation. Inositol Phosphates 55-73 angiotensinogen Rattus norvegicus 38-44 8967472-5 1996 ANG II stimulated the formation of inositol phosphates and increased the level of cytoplasmic Ca2+ in both At1a- and AT1b-transfected Y-1 cells. Inositol Phosphates 35-54 angiotensinogen Rattus norvegicus 0-6 8831515-8 1996 Inositol phosphate response to 0.5 mumol/L Ang II was enhanced 2.1-fold in stretched myocytes. Inositol Phosphates 0-18 angiotensinogen Rattus norvegicus 43-49 8678916-2 1996 Ang II dose-dependently stimulated the formation of choline and inositol phosphates. Inositol Phosphates 64-83 angiotensinogen Rattus norvegicus 0-6 8678916-3 1996 The effect of Ang II on the formation of inositol phosphates (EC50 was 0.249 +/- 0.091 nM) was more potent than that on the formation of choline (EC50 was 2.39 +/- 1.29 nM). Inositol Phosphates 41-60 angiotensinogen Rattus norvegicus 14-20 7554116-9 1995 Compound A, even in the presence of carbenoxolone, effected other glucocorticoid actions by inhibiting cell growth and potentiating angiotensin II-stimulated inositol phosphate formation. Inositol Phosphates 158-176 angiotensinogen Rattus norvegicus 132-146 8733579-15 1996 The activation of PLC and PLA2 in response to AII was evaluated by measuring inositol phosphate production and arachidonic acid release, respectively. Inositol Phosphates 77-95 angiotensinogen Rattus norvegicus 46-49 8566163-7 1995 Angiotensin II activation of both full length and truncated receptors resulted in mobilization of inositol phosphates. Inositol Phosphates 98-117 angiotensinogen Rattus norvegicus 0-14 7730346-6 1995 Agonist-induced internalization of the mutant receptor was also impaired, and its ability to mediate inositol phosphate responses to Ang II stimulation was abolished. Inositol Phosphates 101-119 angiotensinogen Rattus norvegicus 133-139 8001047-3 1994 In addition, the isotonic contractile performance, cytosolic calcium transients, and angiotensin II stimulated inositol phosphate generation in myocytes were measured in the presence and absence of the angiotensin II receptor subtype antagonist losartan. Inositol Phosphates 111-129 angiotensinogen Rattus norvegicus 85-99 8665267-12 1995 Our results further demonstrate the presence of two ANG receptor subtypes in adrenal medulla: ANG binding to AT, receptor stimulates inositol phospholipid metabolism, whereas ANG binding to AT2 receptors decreases both inositol phosphate production and cGMP formation. Inositol Phosphates 219-237 angiotensinogen Rattus norvegicus 52-55 7977687-3 1994 AP ANG II (100 nM)-dependent sodium flux was prevented by preincubation with concentrations of the phospholipase C inhibitor U-73122 (1 microM) that blocked ANG II-dependent inositol phosphate formation. Inositol Phosphates 174-192 angiotensinogen Rattus norvegicus 3-9 7977687-3 1994 AP ANG II (100 nM)-dependent sodium flux was prevented by preincubation with concentrations of the phospholipase C inhibitor U-73122 (1 microM) that blocked ANG II-dependent inositol phosphate formation. Inositol Phosphates 174-192 angiotensinogen Rattus norvegicus 157-163 7977687-4 1994 AP ANG II-dependent sodium flux was also abolished by preincubation with the intracellular calcium mobilization inhibitor 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester (TMB-8), further suggesting that ANG II-dependent sodium transport was mediated by inositol phosphates. Inositol Phosphates 262-281 angiotensinogen Rattus norvegicus 3-9 7977687-6 1994 Incubation with dibutyryl cAMP (10 microM) or forskolin (10 microM) prevented ANG II-dependent sodium flux as well as ANG II-dependent inositol phosphate formation. Inositol Phosphates 135-153 angiotensinogen Rattus norvegicus 118-124 7962104-6 1994 Incubation with aldosterone resulted in potentiation of inositol phosphate formation upon receptor occupation (100 nM angiotensin II) but not upon post-receptor stimulation (25 mM NaF/10 microM AlCl3). Inositol Phosphates 56-74 angiotensinogen Rattus norvegicus 118-132 7945204-5 1994 The early signalling responses activated by AII in RIE-1 cells include increased production of inositol phosphates, a transient increase in the intracellular concentration of free calcium, an activation of protein kinase C, and a rapid change in the pattern of cellular protein-tyrosine phosphorylation. Inositol Phosphates 95-114 angiotensinogen Rattus norvegicus 44-47 7824082-14 1994 Parallel depression of AII-induced inositol phosphates and cAMP accumulation was also observed after EFA deficiency. Inositol Phosphates 35-54 angiotensinogen Rattus norvegicus 23-26 7969043-4 1994 There is a correlative loss of membrane-associated AT1 receptors and angiotensin II-stimulated inositol phosphate production after 24 hr of growth factor treatment. Inositol Phosphates 95-113 angiotensinogen Rattus norvegicus 69-83 7923574-2 1994 Inositol phosphate (IP) turnover was measured by incubating the cells with [3H]inositol and stimulating them with either epidermal growth factor, diferric transferrin, ferricyanide, vasopressin, norepinephrine, angiotensin II or bombesin for 2 min. Inositol Phosphates 0-18 angiotensinogen Rattus norvegicus 211-225 7923574-5 1994 IP turnover was stimulated by vasopressin, norepinephrine and angiotensin II in both normal and nodular cells, but not by the other four agonists tested. Inositol Phosphates 0-2 angiotensinogen Rattus norvegicus 62-76 7923574-2 1994 Inositol phosphate (IP) turnover was measured by incubating the cells with [3H]inositol and stimulating them with either epidermal growth factor, diferric transferrin, ferricyanide, vasopressin, norepinephrine, angiotensin II or bombesin for 2 min. Inositol Phosphates 20-22 angiotensinogen Rattus norvegicus 211-225 1330700-3 1992 EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. Inositol Phosphates 47-66 angiotensinogen Rattus norvegicus 20-26 1338078-7 1992 Incubation of quiescent cells with 0.1 mumol/l angiotensin II resulted in a 65% increase in total [3H]-inositol phosphates released compared with unstimulated cells and in a rapid accumulation of c-fos messenger RNA (mRNA). Inositol Phosphates 103-122 angiotensinogen Rattus norvegicus 47-61 7509802-3 1994 Thrombin and angiotensin II stimulated the hydrolysis of phosphatidylinositol (PI) 4,5-bisphosphate and the formation of several cytosolic species of inositol phosphates without the activation of PI 3-hydroxykinase. Inositol Phosphates 150-169 angiotensinogen Rattus norvegicus 13-27 8447472-0 1993 Fatty acid inhibition of angiotensin II-stimulated inositol phosphates in smooth muscle cells. Inositol Phosphates 51-70 angiotensinogen Rattus norvegicus 25-39 8447472-1 1993 Inositol phosphate (InsP) responses to angiotensin II (ANG II) stimulation were measured in cultured rat vascular smooth muscle cells (VSMC) incubated with and without fatty acids (FA). Inositol Phosphates 0-18 angiotensinogen Rattus norvegicus 39-53 8447472-1 1993 Inositol phosphate (InsP) responses to angiotensin II (ANG II) stimulation were measured in cultured rat vascular smooth muscle cells (VSMC) incubated with and without fatty acids (FA). Inositol Phosphates 0-18 angiotensinogen Rattus norvegicus 55-61 1618554-6 1992 Incubation with aldosterone resulted in enhanced angiotensin II-stimulated phospholipase C activation, as demonstrated by increases in angiotensin II-induced inositol phosphate responses in proportion to the increases in receptor number. Inositol Phosphates 158-176 angiotensinogen Rattus norvegicus 49-63 1329542-2 1992 ANG II-receptor activation induced a prompt (within 15 s) and sustained increase in [3H]inositol phosphates (IPs; inositol trisphosphate, inositol bisphosphate, and inositol monophosphate). Inositol Phosphates 165-187 angiotensinogen Rattus norvegicus 0-6 1417814-3 1992 Binding of angiotensin II to this receptor causes a rapid increase in inositol phosphate production, whereas this effect is not observed in nontransfected cells. Inositol Phosphates 70-88 angiotensinogen Rattus norvegicus 11-25 1417814-4 1992 Des-aspartyl1 angiotensin II and at a lesser extent angiotensin I are also able to produce an increase in inositol phosphates. Inositol Phosphates 106-125 angiotensinogen Rattus norvegicus 14-28 1632771-3 1992 To investigate the intracellular effect of Ang II in skin we determined the levels of total cytoplasmic inositol phosphates after incubation of skin slices with different doses of Ang II. Inositol Phosphates 104-123 angiotensinogen Rattus norvegicus 180-186 1632771-8 1992 Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production. Inositol Phosphates 128-146 angiotensinogen Rattus norvegicus 26-32 1632771-8 1992 Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production. Inositol Phosphates 128-146 angiotensinogen Rattus norvegicus 86-92 1632771-8 1992 Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production. Inositol Phosphates 128-146 angiotensinogen Rattus norvegicus 86-92 1632771-8 1992 Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production. Inositol Phosphates 207-225 angiotensinogen Rattus norvegicus 26-32 1632771-8 1992 Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production. Inositol Phosphates 207-225 angiotensinogen Rattus norvegicus 86-92 1632771-8 1992 Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production. Inositol Phosphates 207-225 angiotensinogen Rattus norvegicus 86-92 1618554-6 1992 Incubation with aldosterone resulted in enhanced angiotensin II-stimulated phospholipase C activation, as demonstrated by increases in angiotensin II-induced inositol phosphate responses in proportion to the increases in receptor number. Inositol Phosphates 158-176 angiotensinogen Rattus norvegicus 135-149 1618554-7 1992 In addition, aldosterone prevented angiotensin II-induced downregulation of angiotensin II surface receptors and angiotensin II desensitization of inositol phosphate formation. Inositol Phosphates 147-165 angiotensinogen Rattus norvegicus 35-49 1618554-8 1992 In summary, aldosterone 1) directly increased angiotensin II receptor number, 2) increased angiotensin II-stimulated inositol phosphate responses, and 3) prevented angiotensin II-induced downregulation and desensitization. Inositol Phosphates 117-135 angiotensinogen Rattus norvegicus 91-105 1618554-8 1992 In summary, aldosterone 1) directly increased angiotensin II receptor number, 2) increased angiotensin II-stimulated inositol phosphate responses, and 3) prevented angiotensin II-induced downregulation and desensitization. Inositol Phosphates 117-135 angiotensinogen Rattus norvegicus 91-105 1698055-1 1990 We have shown previously that exposure of a non-transformed continuous line of rat liver epithelial (WB) cells to epidermal growth factor (EGF), adrenaline, angiotensin II or [Arg8]vasopressin results in an accumulation of the inositol phosphates InsP1, InsP2 and InsP3 [Hepler, Earp & Harden (1988) J. Biol. Inositol Phosphates 227-246 angiotensinogen Rattus norvegicus 157-171 1568763-5 1992 The responsiveness of cytosolic calcium and inositol phosphate accumulation to Ang II was significantly enhanced in mesangial cells from hypertensive rats (10(-7) M Ang II: peak increase of calcium, 1,266 +/- 181 versus 603 +/- 93 nM; percent increment of inositol phosphates at 1 minute, 266 +/- 26 versus 98 +/- 10%). Inositol Phosphates 44-62 angiotensinogen Rattus norvegicus 79-85 1568763-5 1992 The responsiveness of cytosolic calcium and inositol phosphate accumulation to Ang II was significantly enhanced in mesangial cells from hypertensive rats (10(-7) M Ang II: peak increase of calcium, 1,266 +/- 181 versus 603 +/- 93 nM; percent increment of inositol phosphates at 1 minute, 266 +/- 26 versus 98 +/- 10%). Inositol Phosphates 44-62 angiotensinogen Rattus norvegicus 165-171 1568763-5 1992 The responsiveness of cytosolic calcium and inositol phosphate accumulation to Ang II was significantly enhanced in mesangial cells from hypertensive rats (10(-7) M Ang II: peak increase of calcium, 1,266 +/- 181 versus 603 +/- 93 nM; percent increment of inositol phosphates at 1 minute, 266 +/- 26 versus 98 +/- 10%). Inositol Phosphates 256-275 angiotensinogen Rattus norvegicus 79-85 1839152-3 1991 Our results demonstrate that in isolated cells, angiotensin II (AT) stimulates inositol phosphate accumulation, calcium influx and steroid secretion. Inositol Phosphates 79-97 angiotensinogen Rattus norvegicus 48-62 1839152-12 1991 In cultured cells, we observe an additive effect of DA and AT on aldosterone secretion, which is the result of additive interactions of the second messengers involved, namely cAMP for dopamine and inositol phosphates for angiotensin II. Inositol Phosphates 197-216 angiotensinogen Rattus norvegicus 221-235 1659461-4 1991 When compared with controls (5 mM glucose), inositol phosphate release in mesangial cells exposed to 28 mM glucose was decreased by 27% after maximal stimulation with angiotensin II, by 41% after arginine vasopressin, and by 63% after the thromboxane A2 analog, U46619. Inositol Phosphates 44-62 angiotensinogen Rattus norvegicus 167-181 1659461-5 1991 Increasing the concentration of glucose to 50 mM caused a further reduction (from 27 to 54%) in maximal angiotensin II stimulation of inositol phosphate release. Inositol Phosphates 134-152 angiotensinogen Rattus norvegicus 104-118 1848254-5 1991 Higher levels of tritiated inositol phosphates were produced in SHR cells after serum, bradykinin and angiotensin II stimulation, but not in WKY cells after vasopressin. Inositol Phosphates 27-46 angiotensinogen Rattus norvegicus 102-116 19215426-6 1990 Thyrotropin-releasing hormone and angiotensin II stimulated inositol phosphates by adenomatous and 7315a cells. Inositol Phosphates 60-79 angiotensinogen Rattus norvegicus 34-48 1554376-1 1992 The stimulatory effect of angiotensin II (AT) on the accumulation of inositol phosphates and on aldosterone production is abolished by the AT1 selective receptor antagonist DuP753 while PD123177, an AT2 antagonist, is ineffective. Inositol Phosphates 69-88 angiotensinogen Rattus norvegicus 26-40 1329044-6 1992 Angiotensin II, at a dose of 10(-7) M, stimulated inositol phosphate formation 33% over control values in spleen from 8-week-old rats. Inositol Phosphates 50-68 angiotensinogen Rattus norvegicus 0-14 1667760-5 1991 Angiotensin II at a dose of 1 microM stimulated inositol phosphate formation 58% over control values in superior cervical ganglia from 8-week-old rats. Inositol Phosphates 48-66 angiotensinogen Rattus norvegicus 0-14 19215426-4 1990 Purified cells, obtained from the three tissues, were incubated for 30 min in media with drugs (thyrotropin-releasing hormone or angiotensin II) stimulating inositol phosphates and prolactin release, in the presence or the absence of dopamine. Inositol Phosphates 157-176 angiotensinogen Rattus norvegicus 129-143 2244879-6 1990 However, total inositol phosphate responses to endothelin and angiotensin II were similar when these were measured over 20 min, and were quantitatively greater than the vasopressin response. Inositol Phosphates 15-33 angiotensinogen Rattus norvegicus 47-76 2173579-4 1990 Angiotensin II stimulated the labeling of phosphatidylinositol (resynthesis) and the release of inositol phosphates (breakdown). Inositol Phosphates 96-115 angiotensinogen Rattus norvegicus 0-14 1698055-5 1990 The time courses for accumulation of inositol phosphates in response to angiotensin II and EGF were markedly different. Inositol Phosphates 37-56 angiotensinogen Rattus norvegicus 72-86 1698055-6 1990 Whereas angiotensin II stimulated a very rapid accumulation of inositol phosphates (maximal by 30 s), increases in the levels of inositol phosphates in response to EGF were measurable only following a 30 s lag period; maximal levels were attained by 7-8 min. Inositol Phosphates 63-82 angiotensinogen Rattus norvegicus 8-22 1698055-8 1990 Under experimental conditions in which agonist-induced desensitization no longer occurred in these cells, the inositol phosphate responses to EGF and angiotensin II were additive, whereas those to angiotensin II and [Arg8]vasopressin were not additive. Inositol Phosphates 110-128 angiotensinogen Rattus norvegicus 150-164 1698055-9 1990 In crude WB lysates, angiotensin II, [Arg8]vasopressin and adrenaline each stimulated inositol phosphate formation in a guanine-nucleotide-dependent manner. Inositol Phosphates 86-104 angiotensinogen Rattus norvegicus 21-35 2115389-14 1990 Nevertheless, the increase in inositol phosphate formation induced by noradrenaline, angiotensin II, and App(NH)p was not significantly impaired. Inositol Phosphates 30-48 angiotensinogen Rattus norvegicus 85-99 2124471-3 1990 Inositol phosphate formation determined by exchange chromatography in presence of 20 mM LiC1, was stimulated by serum, 1 microM angiotensin II, I microM bradykinin and 0.1 microM vasopressin in both type of cells labelled with 3H myoinositol. Inositol Phosphates 0-18 angiotensinogen Rattus norvegicus 128-142 2402226-7 1990 Saralasin and the nonpeptide antagonists Dup 753 and Exp 6803 blocked angiotensin II-stimulated accumulation of inositol phosphates in cultured Clone 9 cells and also relaxed aortic rings previously contracted with angiotensin II. Inositol Phosphates 112-131 angiotensinogen Rattus norvegicus 70-84 2154205-2 1990 Angiotensin II produced a dose-dependent increase in inositol monophosphate formation with an IC50 of 10(-7)M, when added to isolated rat glomeruli. Inositol Phosphates 53-75 angiotensinogen Rattus norvegicus 0-14 2154205-3 1990 Angiotensin II-stimulated inositol phosphates formation was inhibited by the angiotensin receptor antagonist [Sar-Leu8]angiotensin II, indicating that the above response was mediated through activation of an angiotensin receptor in intact glomeruli. Inositol Phosphates 26-45 angiotensinogen Rattus norvegicus 119-133 2154205-5 1990 Angiotensin II- and bradykinin-stimulated inositol phosphate accumulation in intact glomeruli was inhibited by phorbol myristate acetate, an activator of protein kinase C. Inositol Phosphates 42-60 angiotensinogen Rattus norvegicus 0-14 2154205-3 1990 Angiotensin II-stimulated inositol phosphates formation was inhibited by the angiotensin receptor antagonist [Sar-Leu8]angiotensin II, indicating that the above response was mediated through activation of an angiotensin receptor in intact glomeruli. Inositol Phosphates 26-45 angiotensinogen Rattus norvegicus 0-14 2836390-2 1988 Exposure of a nontransformed, continuous line of epithelial cells derived from rat liver (WB cells) to epidermal growth factor, angiotensin II, [Arg8]vasopressin, and epinephrine resulted in rapid accumulation of the inositol phosphates (InsP) InsP1, InsP2, and InsP3. Inositol Phosphates 217-236 angiotensinogen Rattus norvegicus 128-142 2119636-0 1990 Different inositol phosphate responses to angiotensin II and vasopressin in rat adrenal glomerulosa cells. Inositol Phosphates 10-28 angiotensinogen Rattus norvegicus 42-56 2546842-0 1989 Adrenocorticotropic hormone inhibits angiotensin II-stimulated inositol phosphate accumulation in rat adrenal glomerulosa cells. Inositol Phosphates 63-81 angiotensinogen Rattus norvegicus 37-51 2546842-1 1989 Rat adrenal glomerulosa cells labelled for 18 h with [3H]inositol responded to angiotensin II with a dose-dependent stimulation of the accumulation of inositol monophosphate, inositol bisphosphate and inositol trisphosphate. Inositol Phosphates 151-173 angiotensinogen Rattus norvegicus 79-93 3241219-3 1988 Phospholipase C activity (determined by measuring the formation of tritiated inositol phosphates from [3H]-myoinositol) triggered by angiotensin II was also higher in these cells than in those from WKY. Inositol Phosphates 77-96 angiotensinogen Rattus norvegicus 133-147 2845933-0 1988 Cholera-toxin and corticotropin modulation of inositol phosphate accumulation induced by vasopressin and angiotensin II in rat glomerulosa cells. Inositol Phosphates 46-64 angiotensinogen Rattus norvegicus 105-119 2845933-1 1988 Vasopressin (VP) and angiotensin II (AT II) stimulate the production of inositol phosphates (IP) in rat glomerulosa cells. Inositol Phosphates 72-91 angiotensinogen Rattus norvegicus 21-35 2845933-1 1988 Vasopressin (VP) and angiotensin II (AT II) stimulate the production of inositol phosphates (IP) in rat glomerulosa cells. Inositol Phosphates 72-91 angiotensinogen Rattus norvegicus 37-42 2845933-1 1988 Vasopressin (VP) and angiotensin II (AT II) stimulate the production of inositol phosphates (IP) in rat glomerulosa cells. Inositol Phosphates 93-95 angiotensinogen Rattus norvegicus 21-35 2845933-1 1988 Vasopressin (VP) and angiotensin II (AT II) stimulate the production of inositol phosphates (IP) in rat glomerulosa cells. Inositol Phosphates 93-95 angiotensinogen Rattus norvegicus 37-42 2553959-7 1989 The results establish the identify of the main inositol phosphate products in angiotensin II-stimulated rat glomerulosa cells. Inositol Phosphates 47-65 angiotensinogen Rattus norvegicus 78-92 2449296-9 1988 One minute after addition of 5 nM angiotensin II, inositol monophosphate and inositol bisphosphate levels were increased to 73% and 99%, respectively, above control values and remained elevated at 10 minutes. Inositol Phosphates 50-72 angiotensinogen Rattus norvegicus 34-48 3493002-1 1987 Angiotensin II-induced change in inositol phosphates were studied in cultured rat mesangial cells prelabeled with [3H]myo-inositol. Inositol Phosphates 33-52 angiotensinogen Rattus norvegicus 0-14 3435437-1 1987 analysis of inositol monophosphate isomers formed on angiotensin II stimulation of rat adrenal glomerulosa cells. Inositol Phosphates 12-34 angiotensinogen Rattus norvegicus 53-67 2842898-1 1987 Angiotensin II (2.5 to 250nM) induced, within 60 sec, a significant increase in [3H]inositol-labeled inositol phosphate, inositol bisphosphate, and inositol trisphosphate in rat zona glomerulosa cells. Inositol Phosphates 101-119 angiotensinogen Rattus norvegicus 0-14 2842898-3 1987 A similar significant dose-dependent increase in the inositol phosphates was observed with angiotensin II in zona fasciculata/reticularis cells after 30 min, but without any effect on corticosterone. Inositol Phosphates 53-72 angiotensinogen Rattus norvegicus 91-105 2830094-2 1988 After the addition of angiotensin II, inositol monophosphate, inositol bisphosphate, and inositol trisphosphate increased rapidly and transiently. Inositol Phosphates 38-60 angiotensinogen Rattus norvegicus 22-36 3280722-0 1988 Evidence that angiotensin II is a paracrine agent mediating gonadotrophin-releasing hormone-stimulated inositol phosphate production and prolactin secretion in the rat. Inositol Phosphates 103-121 angiotensinogen Rattus norvegicus 14-28 3280722-2 1988 Saralasin [( Sar1, Ala8]-angiotensin II; a competitive antagonist of angiotensin II) inhibited the increase in both inositol phosphates and prolactin in a dose-dependent manner. Inositol Phosphates 116-135 angiotensinogen Rattus norvegicus 25-39 3280722-2 1988 Saralasin [( Sar1, Ala8]-angiotensin II; a competitive antagonist of angiotensin II) inhibited the increase in both inositol phosphates and prolactin in a dose-dependent manner. Inositol Phosphates 116-135 angiotensinogen Rattus norvegicus 69-83 3280722-3 1988 Since angiotensin II has been shown to be a potent stimulus for inositol phosphate accumulation and prolactin secretion in the lactotroph, these findings suggest that angiotensin II acts as a paracrine agent, being released from the gonadotroph in response to GnRH and causing the lactotroph to release prolactin through an effect on phosphoinositide metabolism. Inositol Phosphates 64-82 angiotensinogen Rattus norvegicus 6-20 3280722-3 1988 Since angiotensin II has been shown to be a potent stimulus for inositol phosphate accumulation and prolactin secretion in the lactotroph, these findings suggest that angiotensin II acts as a paracrine agent, being released from the gonadotroph in response to GnRH and causing the lactotroph to release prolactin through an effect on phosphoinositide metabolism. Inositol Phosphates 64-82 angiotensinogen Rattus norvegicus 167-181 3342050-1 1988 Angiotensin II causes an increase of inositol phosphate production in cultured vascular smooth muscle cells from rat aorta. Inositol Phosphates 37-55 angiotensinogen Rattus norvegicus 0-14 2824567-1 1987 Angiotensin II (AII) in adrenal glomerulosa cells activates phospholipase C resulting in the formation of inositol phosphates and diacylglycerol rich in arachidonic acid (AA). Inositol Phosphates 106-125 angiotensinogen Rattus norvegicus 0-14 2824567-1 1987 Angiotensin II (AII) in adrenal glomerulosa cells activates phospholipase C resulting in the formation of inositol phosphates and diacylglycerol rich in arachidonic acid (AA). Inositol Phosphates 106-125 angiotensinogen Rattus norvegicus 16-19 3499482-0 1987 Stimulation by bradykinin, angiotensin II, and carbachol of the accumulation of inositol phosphates in PC-12 pheochromocytoma cells: differential effects of lithium ions on inositol mono- and polyphosphates. Inositol Phosphates 80-99 angiotensinogen Rattus norvegicus 27-41 3499482-1 1987 Rat PC-12 pheochromocytoma cells respond to stimulation with bradykinin, angiotensin II, and carbachol with an increased formation of labeled inositol phosphates after preincubation of the cells with [3H]inositol. Inositol Phosphates 142-161 angiotensinogen Rattus norvegicus 73-87 3039502-3 1987 The increase in Ca2+ due to angiotensin II was associated with an increase in inositol phosphates, while that due to K+ was not. Inositol Phosphates 78-97 angiotensinogen Rattus norvegicus 28-42 3036625-2 1987 Here we report that under such conditions there is a decrease in the capacity of the cells to form inositol phosphates in response to a subsequent stimulation with AII. Inositol Phosphates 99-118 angiotensinogen Rattus norvegicus 164-167 2842898-0 1987 Angiotensin II-induced inositol phosphate production in isolated rat zona glomerulosa and fasciculata/reticularis cells. Inositol Phosphates 23-41 angiotensinogen Rattus norvegicus 0-14 3493002-4 1987 Angiotensin II-induced increases in inositol phosphates were dose-dependent and completely blocked by saralasin. Inositol Phosphates 36-55 angiotensinogen Rattus norvegicus 0-14 3493002-5 1987 These results indicate that angiotensin II induces the production of inositol phosphates including inositol 1,4,5-trisphosphate, an intracellular Ca2+-releasing factor, in cultured rat mesangial cells. Inositol Phosphates 69-88 angiotensinogen Rattus norvegicus 28-42 3020141-1 1986 The hydrolysis of membrane phosphatidylinositol to yield [3H]labelled inositol phosphates by anterior pituitary cells was stimulated significantly by angiotensin II, TRH and neurotensin over a broad range of concentrations. Inositol Phosphates 70-89 angiotensinogen Rattus norvegicus 150-164 3025836-1 1986 The production and metabolism of inositol phosphates in rat adrenal glomerulosa cells prelabeled with [3H]inositol and stimulated with angiotensin II were analyzed by high-performance anion-exchange chromatography. Inositol Phosphates 33-52 angiotensinogen Rattus norvegicus 135-149 3084474-1 1986 Angiotensin II acts on cultured rat aortic vascular smooth muscle cells to stimulate phospholipase C-mediated hydrolysis of membrane phosphoinositides and subsequent formation of diacylglycerol and inositol phosphates. Inositol Phosphates 198-217 angiotensinogen Rattus norvegicus 0-14 3089838-0 1986 Tumour promotor 12-O-tetradecanoylphorbol 13-acetate inhibits angiotensin II-induced inositol phosphate production and cytosolic Ca2+ rise in rat renal mesangial cells. Inositol Phosphates 85-103 angiotensinogen Rattus norvegicus 62-76 2985562-8 1985 A high concentration of angiotensin II and [Arg]vasopressin elicited progressive accumulations of inositol phosphates. Inositol Phosphates 98-117 angiotensinogen Rattus norvegicus 24-38 3090472-0 1986 Angiotensin II stimulates inositol phosphate formation in rat anterior pituitary glands. Inositol Phosphates 26-44 angiotensinogen Rattus norvegicus 0-14 3090472-3 1986 Time course studies showed that the stimulation of IP3 formation by AII was significant after 2 min incubation and preceded the accumulation of the other inositol phosphates. Inositol Phosphates 154-173 angiotensinogen Rattus norvegicus 68-71 2985562-9 1985 Only high concentrations of angiotensin II caused inositol phosphate accumulation in Ca2+-free medium. Inositol Phosphates 50-68 angiotensinogen Rattus norvegicus 28-42 2985562-10 1985 Maximal accumulation of inositol phosphate elicited by angiotensin II and [Arg]vasopressin was found to be additive. Inositol Phosphates 24-42 angiotensinogen Rattus norvegicus 55-69 11171601-8 2001 ANG II pretreatment also desensitized ANG II- and TRH-induced inositol phosphate generation (72.8 +/- 3.5 and 69.6 +/- 6.1%, respectively, for inositol triphosphate) and prolactin secretion (53.4 +/- 2.3 and 65.1 +/- 7.2%), effects independent of PKC activation. Inositol Phosphates 62-80 angiotensinogen Rattus norvegicus 0-6 15905421-5 2005 EGF-induced AT(1)-R phosphorylation was associated with a decrease in membrane-associated AT(1)-Rs and a reduced inositol phosphate response to Ang II. Inositol Phosphates 113-131 angiotensinogen Rattus norvegicus 144-150 15905421-7 2005 The dependence of these responses on caveolin was indicated by the finding that cholesterol depletion of C9 cells abolished Ang II-induced inositol phosphate production, activation of Akt/PKB and ERK1/2, and AT(1)-R internalization. Inositol Phosphates 139-157 angiotensinogen Rattus norvegicus 124-130 15319432-3 2004 Cells expressing QM have 5-fold higher levels of angiotensin II-induced inositol phosphate production than wild type (WT). Inositol Phosphates 72-90 angiotensinogen Rattus norvegicus 49-63 12534362-0 2003 Nitric oxide decreases the production of inositol phosphates stimulated by angiotensin II and thyrotropin-releasing hormone in anterior pituitary cells. Inositol Phosphates 41-60 angiotensinogen Rattus norvegicus 75-89 16989733-2 2006 We investigated the time-dependent effects of AII on both phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol phosphates (InsPs) accumulation in permeabilized microsomes from rat portal vein smooth muscle in comparison with those of noradrenaline (NA). Inositol Phosphates 114-133 angiotensinogen Rattus norvegicus 46-49 15254973-6 2004 Consistently, EGF inhibited AngII-stimulated formation of inositol phosphates in the presence of cycloheximide but not in the presence of actinomycin D or cytochalasin D. Inositol Phosphates 58-77 angiotensinogen Rattus norvegicus 28-33 11861492-1 2002 Dopamine (DA) is known to inhibit basal and hormone TRH- or angiotensin II (AngII)-stimulated PRL secretion and inositol phosphate accumulation in rat pituitary cells in primary culture. Inositol Phosphates 112-130 angiotensinogen Rattus norvegicus 60-74 11171601-8 2001 ANG II pretreatment also desensitized ANG II- and TRH-induced inositol phosphate generation (72.8 +/- 3.5 and 69.6 +/- 6.1%, respectively, for inositol triphosphate) and prolactin secretion (53.4 +/- 2.3 and 65.1 +/- 7.2%), effects independent of PKC activation. Inositol Phosphates 62-80 angiotensinogen Rattus norvegicus 38-44 11078714-1 2000 We have studied G(q)-linked ANG II signaling [inositol phosphate (IP) accumulation, Ca(2+) mobilization] in primary cultures of rat cardiac fibroblasts (CFs) and have found that ANG II initiates a protein kinase C (PKC)-mediated negative feedback loop that rapidly terminates the ANG II response. Inositol Phosphates 46-64 angiotensinogen Rattus norvegicus 178-184 11078714-1 2000 We have studied G(q)-linked ANG II signaling [inositol phosphate (IP) accumulation, Ca(2+) mobilization] in primary cultures of rat cardiac fibroblasts (CFs) and have found that ANG II initiates a protein kinase C (PKC)-mediated negative feedback loop that rapidly terminates the ANG II response. Inositol Phosphates 46-64 angiotensinogen Rattus norvegicus 178-184 9892139-3 1999 They belong to the AT1 subtype as shown by the inhibitory effect of AT1 antagonists on [125I]-Sar1, Ala8 AngII binding and on all of the biologic effects mediated by AngII, such as cytosolic calcium stimulation, inositol phosphate formation, prostaglandin production, and cell contraction. Inositol Phosphates 212-230 angiotensinogen Rattus norvegicus 166-171 10477083-2 1999 Angiotensin II stimulated a dose-dependent release of amylase and production of inositol phosphates. Inositol Phosphates 80-99 angiotensinogen Rattus norvegicus 0-14 10903964-2 2000 The role of different residues of the rat AT(1A) receptor in the interaction with the N- and C-terminal ends of angiotensin II (AngII) was studied by determining ligand binding and production of inositol phosphates (IP) in COS-7 cells transiently expressing the following AT(1A) mutants: T88H, Y92H, G196I, G196W and D278E. Inositol Phosphates 216-218 angiotensinogen Rattus norvegicus 112-126 10903964-2 2000 The role of different residues of the rat AT(1A) receptor in the interaction with the N- and C-terminal ends of angiotensin II (AngII) was studied by determining ligand binding and production of inositol phosphates (IP) in COS-7 cells transiently expressing the following AT(1A) mutants: T88H, Y92H, G196I, G196W and D278E. Inositol Phosphates 216-218 angiotensinogen Rattus norvegicus 128-133 10418735-3 1999 The ability of AT-II to promote formation of inositol phosphates, the second messenger produced by the activation of Gq-coupled receptors, was also considerably suppressed in the cirrhotic VSMCs. Inositol Phosphates 45-64 angiotensinogen Rattus norvegicus 15-20