PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9321797-4 1997 Gentamicin (150 microM) inhibited inositol phosphate responses in the presence of either norepinephrine or thrombin but did not inhibit the response to ET-1, providing additional evidence that the inositol phosphate response to ET-1 does not involve formation of Ins(1,4,5)P3, even under reperfusion conditions. Inositol Phosphates 197-215 endothelin 1 Rattus norvegicus 228-232 10763853-9 2000 ET-1 (1 nM) caused significant increases in intracellular inositol phosphates, with levels generally higher in rat than in guinea-pig trachea. Inositol Phosphates 58-77 endothelin 1 Rattus norvegicus 0-4 10763853-10 2000 ET-1-induced inositol phosphate accumulation decreased significantly with respect to animal age in both guinea-pig and rat isolated tracheal tissue. Inositol Phosphates 13-31 endothelin 1 Rattus norvegicus 0-4 10763853-12 2000 For example, in both rat and guinea-pig, the smallest ET-1-induced increases in intracellular inositol phosphates were measured in airway smooth muscle from the oldest animals tested, although tissue sensitivity to ET-1 was stable in both species after 12 weeks of age. Inositol Phosphates 94-113 endothelin 1 Rattus norvegicus 54-58 8982672-2 1996 BQ-123 (cyclo(D-Trp,D-Asp,L-Pro,D-Val,L-Leu), a selective endothelin ETA receptor antagonist, reduced the endothelin-1- and endothelin-3-induced [3H]inositol phosphate production, with similar inhibition constants (IC50: 16.7 +/- 3.4 and 8.0 +/- 1.6 microM, respectively). Inositol Phosphates 149-167 endothelin 1 Rattus norvegicus 106-118 8982672-1 1996 In rat spinal cord slices, endothelin-1 and endothelin-3 enhanced [3H]inositol phosphate production between 1 nM and 10 microM (endothelin-1 > endothelin-3) while sarafotoxin 6c and the endothelin ETB receptor agonist IRL-1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21)) were almost ineffective. Inositol Phosphates 70-88 endothelin 1 Rattus norvegicus 27-39 8982672-1 1996 In rat spinal cord slices, endothelin-1 and endothelin-3 enhanced [3H]inositol phosphate production between 1 nM and 10 microM (endothelin-1 > endothelin-3) while sarafotoxin 6c and the endothelin ETB receptor agonist IRL-1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21)) were almost ineffective. Inositol Phosphates 70-88 endothelin 1 Rattus norvegicus 128-140 8982672-1 1996 In rat spinal cord slices, endothelin-1 and endothelin-3 enhanced [3H]inositol phosphate production between 1 nM and 10 microM (endothelin-1 > endothelin-3) while sarafotoxin 6c and the endothelin ETB receptor agonist IRL-1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21)) were almost ineffective. Inositol Phosphates 70-88 endothelin 1 Rattus norvegicus 128-140 9045727-6 1997 Biochemical assays and focal applications of several agonists (methoxamine, carbachol, glutamate) of membrane receptors to neurotransmitters and peptides (endothelin 1) demonstrated that their ability to trigger regenerative calcium waves depended on phospholipase C activity and inositol phosphate production. Inositol Phosphates 280-298 endothelin 1 Rattus norvegicus 155-167 9085052-2 1997 Exogenous endothelin-1 and big-endothelin-1 both increased arachidonic acid release and inositol phosphate production dose dependently. Inositol Phosphates 88-106 endothelin 1 Rattus norvegicus 10-22 9085052-2 1997 Exogenous endothelin-1 and big-endothelin-1 both increased arachidonic acid release and inositol phosphate production dose dependently. Inositol Phosphates 88-106 endothelin 1 Rattus norvegicus 31-43 9085052-3 1997 Endothelin-1 was more potent than big-endothelin-1 as indicated by EC50 values: 0.5 +/- 0.1 nM and 10.0 +/- 2.0 nM for endothelin-1-induced arachidonic acid release and inositol phosphate formation, respectively, versus 1.0 +/- 0.4 nM and 35.0 +/- 6.0 nM for big-endothelin-1-induced responses. Inositol Phosphates 169-187 endothelin 1 Rattus norvegicus 0-12 9085052-3 1997 Endothelin-1 was more potent than big-endothelin-1 as indicated by EC50 values: 0.5 +/- 0.1 nM and 10.0 +/- 2.0 nM for endothelin-1-induced arachidonic acid release and inositol phosphate formation, respectively, versus 1.0 +/- 0.4 nM and 35.0 +/- 6.0 nM for big-endothelin-1-induced responses. Inositol Phosphates 169-187 endothelin 1 Rattus norvegicus 38-50 9085052-3 1997 Endothelin-1 was more potent than big-endothelin-1 as indicated by EC50 values: 0.5 +/- 0.1 nM and 10.0 +/- 2.0 nM for endothelin-1-induced arachidonic acid release and inositol phosphate formation, respectively, versus 1.0 +/- 0.4 nM and 35.0 +/- 6.0 nM for big-endothelin-1-induced responses. Inositol Phosphates 169-187 endothelin 1 Rattus norvegicus 119-131 9085052-3 1997 Endothelin-1 was more potent than big-endothelin-1 as indicated by EC50 values: 0.5 +/- 0.1 nM and 10.0 +/- 2.0 nM for endothelin-1-induced arachidonic acid release and inositol phosphate formation, respectively, versus 1.0 +/- 0.4 nM and 35.0 +/- 6.0 nM for big-endothelin-1-induced responses. Inositol Phosphates 169-187 endothelin 1 Rattus norvegicus 119-131 8932513-4 1996 Furthermore, ET-1 caused an increase in the generation of inositol phosphates and diacylglycerol (DAG). Inositol Phosphates 58-77 endothelin 1 Rattus norvegicus 13-17 8756004-6 1996 ET-1 enhanced PLC activity, as indicated by increased inositol phosphate production, which was prevented by a PLC inhibitor, U-73122. Inositol Phosphates 54-72 endothelin 1 Rattus norvegicus 0-4 10968205-1 1996 To examine potential intracellular signalling abnormalities of endothelin-1 (ET-1) and vasopressin (AVP) which may contribute to blood pressure elevation, contractility and inositol phosphate levels in intact arteries and calcium transients in vascular smooth muscle cells were investigated after stimulation with these peptides in pre-hypertensive 5 week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats. Inositol Phosphates 173-191 endothelin 1 Rattus norvegicus 63-75 10968205-1 1996 To examine potential intracellular signalling abnormalities of endothelin-1 (ET-1) and vasopressin (AVP) which may contribute to blood pressure elevation, contractility and inositol phosphate levels in intact arteries and calcium transients in vascular smooth muscle cells were investigated after stimulation with these peptides in pre-hypertensive 5 week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats. Inositol Phosphates 173-191 endothelin 1 Rattus norvegicus 77-81 10968205-4 1996 Basal inositol phosphate in aorta and mesenteric arteries was elevated in SHR, but ET-1 and AVP-stimulated inositol phosphate responses were similar in both groups. Inositol Phosphates 107-125 endothelin 1 Rattus norvegicus 83-95 10968205-6 1996 In contrast, in adult rats inositol phosphate responses to ET-1 were blunted in aorta of SHR, but were normal in mesenteric arteries. Inositol Phosphates 27-45 endothelin 1 Rattus norvegicus 59-63 10968205-10 1996 Signal transduction in response to ET-1 and AVP is depressed in aorta of pre-hypertensive SHR after the step of inositol phosphate generation and calcium mobilization. Inositol Phosphates 112-130 endothelin 1 Rattus norvegicus 35-47 8762046-6 1996 When 20:5n-3-treated cells were stimulated with phenylephrine or endothelin-1, the inositolphosphate production decreased by 33.2% and increased by 43.4%, respectively, as compared to cells grown in control medium. Inositol Phosphates 83-100 endothelin 1 Rattus norvegicus 65-77 8762046-8 1996 When 18:0/18:1n-9-treated cells were stimulated with endothelin-1, inositolphosphate formation increased by 26.4%, whereas phenylephrine-stimulated inositolphosphate formation was not affected. Inositol Phosphates 67-84 endothelin 1 Rattus norvegicus 53-65 8587386-3 1995 ET-1 induced production of inositol phosphates and an increase of cAMP level in ROS 17/2 cells. Inositol Phosphates 27-46 endothelin 1 Rattus norvegicus 0-4 8825336-6 1996 Treatment of the cells with endothelin-1 (ET-1) increased formation of inositol phosphates and elevated [Ca2+]i due to both release of Ca2+ from intracellular pools and prolonged entry of Ca2+ from outside the cell. Inositol Phosphates 71-90 endothelin 1 Rattus norvegicus 28-40 8825336-6 1996 Treatment of the cells with endothelin-1 (ET-1) increased formation of inositol phosphates and elevated [Ca2+]i due to both release of Ca2+ from intracellular pools and prolonged entry of Ca2+ from outside the cell. Inositol Phosphates 71-90 endothelin 1 Rattus norvegicus 42-46 8825336-7 1996 Propofol reduced production of inositol phosphates mediated by ET-1 and arginine vasopressin which activate phospholipase C. 3. Inositol Phosphates 31-50 endothelin 1 Rattus norvegicus 63-67 8746950-1 1995 Previously we demonstrated that stimulation of cultured neonatal rat ventricular myocytes by either alpha 1-adrenergic agonist or endothelin-1 resulted in a rapid formation of total inositolphosphates, although the levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate did not rise significantly. Inositol Phosphates 182-200 endothelin 1 Rattus norvegicus 130-142 7613525-0 1995 Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR and WKY cultured aortic smooth muscle cells. Inositol Phosphates 51-69 endothelin 1 Rattus norvegicus 26-38 7613525-2 1995 Endothelin-1 (10(-6) M) stimulated IP formation was decreased in cells from SHR compared to WKY (WKY 1117 +/- 157, SHR 668 +/- 85% of basal). Inositol Phosphates 35-37 endothelin 1 Rattus norvegicus 0-12 7581972-6 1995 Endothelin-1 and oxytocin stimulated inositol phosphate accumulation at concentrations similar to those that promoted 45Ca2+ efflux, whereas about 100 times higher concentrations of PGF2 alpha were needed to activate this signaling pathway in intact cells. Inositol Phosphates 37-55 endothelin 1 Rattus norvegicus 0-12 8587397-1 1995 In estrogen-treated rat myometrium, endothelin-1 (ET-1) activated both the phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway (PLD) as evidenced in the presence of butanol by an increased production of phosphatidylbutanol (PBut). Inositol Phosphates 164-183 endothelin 1 Rattus norvegicus 36-48 8587397-1 1995 In estrogen-treated rat myometrium, endothelin-1 (ET-1) activated both the phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway (PLD) as evidenced in the presence of butanol by an increased production of phosphatidylbutanol (PBut). Inositol Phosphates 164-183 endothelin 1 Rattus norvegicus 50-54 7980611-7 1994 ET-1-stimulated production of inositol phosphates was not affected by pretreatment with PTX. Inositol Phosphates 30-49 endothelin 1 Rattus norvegicus 0-4 8131942-0 1993 Endothelin-1 stimulates inositol phosphate production in rat testis. Inositol Phosphates 24-42 endothelin 1 Rattus norvegicus 0-12 7935329-7 1994 Exposure to ET-1 (15 min) resulted in concentration-dependent and homologous desensitization (40%) of the inositol phosphate response triggered by ET-1. Inositol Phosphates 106-124 endothelin 1 Rattus norvegicus 12-16 7935329-7 1994 Exposure to ET-1 (15 min) resulted in concentration-dependent and homologous desensitization (40%) of the inositol phosphate response triggered by ET-1. Inositol Phosphates 106-124 endothelin 1 Rattus norvegicus 147-151 7957641-6 1994 In both hypertensive and normotensive rats, for a given Ca2+ mobilisation, higher contractile responses and higher levels of inositol phosphates were observed after endothelin-1 than noradrenaline stimulation. Inositol Phosphates 125-144 endothelin 1 Rattus norvegicus 165-177 8170471-9 1994 The release of total inositol phosphates in response to ET-1 and AII was concentration dependent and inhibited by the ETA receptor-selective antagonist BQ-123 and the AT1 receptor-selective antagonist losartan, respectively. Inositol Phosphates 21-40 endothelin 1 Rattus norvegicus 56-68 8136771-2 1994 Both basal and agonist (noradrenaline and endothelin-1) stimulated levels of inositol phosphates were studied. Inositol Phosphates 77-96 endothelin 1 Rattus norvegicus 42-54 7935329-1 1994 In estradiol-dominated rat myometrium, endothelin (ET)-1 caused contraction and increased the accumulation of [3H]inositol phosphates (EC50 = 70 nM), with the sequential generation of inositol trisphosphate, inositol bisphosphate, and inositol monophosphate. Inositol Phosphates 235-257 endothelin 1 Rattus norvegicus 39-56 1337016-0 1992 Inositol phosphate production in response to [Arg8]vasopressin, endothelin 1, and prostaglandin F2 alpha in rat aorta and mesenteric arteries. Inositol Phosphates 0-18 endothelin 1 Rattus norvegicus 64-76 8248864-6 1993 As measured by [3H]inositol monophosphate ([3H]InsP1) accumulation, normal rat seru, ET-1, and ET-2 stimulated phosphoinositide hydrolysis 47%, 420%, and 154% above the basal rate observed in serum free controls. Inositol Phosphates 19-41 endothelin 1 Rattus norvegicus 85-89 8396963-1 1993 Induction of phosphoinositide hydrolysis in rat cerebellar slices by endothelins (ET-1 and ET-3) and sarafotoxins (SRTX-b and SRTX-c) was demonstrated by measurement of labelled inositol phosphate generation. Inositol Phosphates 178-196 endothelin 1 Rattus norvegicus 82-95 8205317-0 1993 Comparison of endothelin-1 and noradrenaline stimulated inositol phosphate formation in cultured aortic smooth muscle cells from spontaneously hypertensive and Wistar Kyoto rats. Inositol Phosphates 56-74 endothelin 1 Rattus norvegicus 14-26 8205317-5 1993 In cultured smooth muscle cells from 14-week SHR a decrease was observed in endothelin-1 stimulated inositol phosphate formation compared to controls. Inositol Phosphates 100-118 endothelin 1 Rattus norvegicus 76-88 8205317-8 1993 However, in established hypertension (14 weeks) cells from SHR have altered total [3H] inositol phosphate formation in response to stimulation with noradrenaline and endothelin-1 although these changes are in opposite directions. Inositol Phosphates 87-105 endothelin 1 Rattus norvegicus 166-178 8242481-5 1993 The dose-response of inositol phosphates to ET-1 was significantly blunted in thoracic aorta of SHR compared with WKY rats, whereas it was similar in the mesenteric arterial bed. Inositol Phosphates 21-40 endothelin 1 Rattus norvegicus 44-48 8382749-3 1993 Endothelin-1 (10(-8) M) evoked phosphoinositide turnover in the presence of 10 mM LiCl, which was greatly attenuated after 30-45 min of continuous stimulation with agonist, apparently resulting in a total absence of further inositol-phosphate accumulation. Inositol Phosphates 224-242 endothelin 1 Rattus norvegicus 0-12 8081727-2 1993 Induction of phosphoinositide hydrolysis in this preparation by endothelins (ET-1 and ET-3) or sarafotoxins (SRTX-b and SRTX-c) was demonstrated by measurement of labeled inositol phosphate generation. Inositol Phosphates 171-189 endothelin 1 Rattus norvegicus 77-90 1337016-8 1992 The accumulation of total inositol phosphates induced by maximum concentrations of ET-1 was greater than in response to AVP or PGF2 alpha. Inositol Phosphates 26-45 endothelin 1 Rattus norvegicus 83-87 1337016-9 1992 Dose-response curves showed that the rank order of potency for stimulation of production of inositol phosphates was AVP > ET-1 > PGF2 alpha, similar to the sensitivity of blood vessels to these agents. Inositol Phosphates 92-111 endothelin 1 Rattus norvegicus 125-129 1333720-13 1992 Endothelin-1 also stimulated the dose-dependent production of inositol phosphates by UMR-106 cells. Inositol Phosphates 62-81 endothelin 1 Rattus norvegicus 0-12 2054934-7 1991 ET-1 remarkably and dose-dependently stimulated accumulation of total inositol phosphates in cardiomyocytes. Inositol Phosphates 70-89 endothelin 1 Rattus norvegicus 0-4 1317355-7 1992 Inositol phosphate production after stimulation with 100 nmol/l ET-1 in the presence of LiCl was lower by at least 30% (p less than 0.01) in both aorta and mesenteric arteries of DOCA-salt hypertensive versus control rats. Inositol Phosphates 0-18 endothelin 1 Rattus norvegicus 64-68 1310486-1 1992 The vasoconstrictor effect, the binding, and the response of inositol phosphates to endothelin-1 (ET-1) were investigated in blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats within 2 weeks of development of hypertension and in uninephrectomized control rats. Inositol Phosphates 61-80 endothelin 1 Rattus norvegicus 84-96 1310486-1 1992 The vasoconstrictor effect, the binding, and the response of inositol phosphates to endothelin-1 (ET-1) were investigated in blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats within 2 weeks of development of hypertension and in uninephrectomized control rats. Inositol Phosphates 61-80 endothelin 1 Rattus norvegicus 98-102 1764024-6 1991 The inositol phosphate response to ET-1 is poorly potentiated by guanosine 5"-[gamma-thio]triphosphate (GTP[S]) and markedly inhibited by guanosine 5"-[beta-thio]diphosphate (GDP[S]), whereas that to LPA is potentiated by GTP[S] but is relatively insensitive to GDP[S]. Inositol Phosphates 4-22 endothelin 1 Rattus norvegicus 35-39 1744468-0 1991 Endothelin-1 induces inositol phosphate production in rat pregnant myometrium. Inositol Phosphates 21-39 endothelin 1 Rattus norvegicus 0-12 1380304-4 1992 At concentrations of endothelin which transiently increased Ca2+, ET-1 increased the accumulation of inositol phosphates. Inositol Phosphates 101-120 endothelin 1 Rattus norvegicus 66-70 1596675-0 1992 Endothelin-1-induced [3H]-inositol phosphate accumulation in rat trachea. Inositol Phosphates 26-44 endothelin 1 Rattus norvegicus 0-12 1662384-4 1991 ET-1 was more potent than ET-3 in mobilizing inositol phosphates, consistent with its greater affinity for the ET receptors in these cells. Inositol Phosphates 45-64 endothelin 1 Rattus norvegicus 0-4 1663049-3 1991 Endothelin-1, endothelin-3 and the endothelin-related peptide sarafatoxin S6b all stimulated the accumulation of inositol phosphates in [3H]inositol-labelled papillary tubule preparations. Inositol Phosphates 113-132 endothelin 1 Rattus norvegicus 0-12 2561134-2 1989 Endothelin-1 induced a dose-dependent increase in inositol monophosphate production in both groups, but the reactivity of the phosphoinositide pathway was enhanced in DOCA-salt hypertensive rats. Inositol Phosphates 50-72 endothelin 1 Rattus norvegicus 0-12 1900389-3 1991 In addition, in intact cells, pertussis toxin partially inhibited the stimulation of total inositol phosphates (IPn) by ET. Inositol Phosphates 91-110 endothelin 1 Rattus norvegicus 120-122 2155922-5 1990 ET stimulates production of inositol phosphates in membranes prepared from A-10 cells in the presence of guanosine 5"-O-(thiotriphosphate) (GTP gamma S), but not in its absence. Inositol Phosphates 28-47 endothelin 1 Rattus norvegicus 0-2 2473325-9 1989 EC-CM and ET-1 also resulted in time- and concentration-dependent increases in inositol monophosphate (IP) formation in rat aorta that paralleled the development of isometric force. Inositol Phosphates 79-101 endothelin 1 Rattus norvegicus 10-14 17585504-2 2007 Our data show that ET-1, ET-3 and the ETB-receptors agonist, IRL 1620, increased inositol monophosphate (InsP1) accumulation, NOS activity and cGMP formation, in a similar degree. Inositol Phosphates 81-103 endothelin 1 Rattus norvegicus 19-29