PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29030193-0	2018	Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on alpha-glucosidase.	Oleanolic Acid	51-65	sucrase-isomaltase	Homo sapiens	86-103	
29030193-2	2018	This work is to investigate the kinetics and inhibition mechanism of oleanolic acid and ursolic acid on alpha-glucosidase.	Oleanolic Acid	69-83	sucrase-isomaltase	Homo sapiens	104-121	
29030193-5	2018	The binding constants of oleanolic acid and ursolic acid with alpha-glucosidase at 298K were (2.04+-0.02)x103 and (1.87+-0.02)x103Lmol-1, respectively.	Oleanolic Acid	25-39	sucrase-isomaltase	Homo sapiens	62-79	
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	124-141	
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	233-250	
29030193-8	2018	The combination of oleanolic acid and ursolic acid displayed a significant synergistic inhibition on alpha-glucosidase.	Oleanolic Acid	19-33	sucrase-isomaltase	Homo sapiens	101-118	
20390739-0	2010	Synthesis and alpha-glucosidase inhibitory activity of oleanolic acid derivatives.	Oleanolic Acid	55-69	sucrase-isomaltase	Homo sapiens	14-31	
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	Oleanolic Acid	103-117	sucrase-isomaltase	Homo sapiens	4-21	
26205959-0	2015	alpha-Glucosidase activity of oleanolic acid and its oxidative metabolites: DFT and Docking studies.	Oleanolic Acid	30-44	sucrase-isomaltase	Homo sapiens	0-17	
26205959-1	2015	A natural pentacyclic triterpenoid oleanolic acid 1 and its biotransformed metabolites 2-3 are potential alpha-glucosidase inhibitors.	Oleanolic Acid	35-49	sucrase-isomaltase	Homo sapiens	105-122	
26207761-4	2015	Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against alpha-amylase and alpha-glucosidase.	Oleanolic Acid	111-125	sucrase-isomaltase	Homo sapiens	211-228	
21804254-0	2011	Synthesis of new alpha-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides.	Oleanolic Acid	55-69	sucrase-isomaltase	Homo sapiens	17-34	
21804254-1	2011	A series of alpha-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized.	Oleanolic Acid	50-64	sucrase-isomaltase	Homo sapiens	12-29	
18415855-0	2008	Microbial transformation of oleanolic acid by Fusarium lini and alpha-glucosidase inhibitory activity of its transformed products.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	64-81	
29677678-1	2018	During the last decade, ursolic and oleanolic acids have been of considerable interest because of their alpha-glucosidase inhibitory activities and potential effects for treatment of type 2 diabetes.	Oleanolic Acid	36-51	sucrase-isomaltase	Homo sapiens	104-121	
12031449-0	2002	Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives.	Oleanolic Acid	35-49	sucrase-isomaltase	Homo sapiens	14-31	
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	58-72	sucrase-isomaltase	Homo sapiens	84-101	
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	58-72	sucrase-isomaltase	Homo sapiens	161-178	
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	74-76	sucrase-isomaltase	Homo sapiens	84-101	
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	74-76	sucrase-isomaltase	Homo sapiens	161-178	
33418317-7	2021	Findings from this study support that OA indole derivatives are promising alpha-glucosidase inhibitors as a potential management of diabetes mellitus.	Oleanolic Acid	38-40	sucrase-isomaltase	Homo sapiens	74-91