PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33130471-0	2021	Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-kappaB and STAT1 activation.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	85-88	
33573541-1	2021	Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-kappaB/ICAM-1/JAK/STAT signaling pathways, etc.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	282-285	
29908114-3	2016	Results showed that different concentrations of oleanolic acid(<=40 mumol L(-1)) were almost non-toxicity to SW982 cells; oleanolic acid significantly inhibited the expression of inflammatory factors in a dose-dependent manner; oleanolic acid restrained extracellular signal-related kinase (ERK), p38, c-jun N-terminal kinase (JNK) and Akt protein phosphorylation and IkappaB-alpha protein degradation obviously.	Oleanolic Acid	48-62	AKT serine/threonine kinase 1	Homo sapiens	339-342	
31441181-0	2019	Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling.	Oleanolic Acid	20-34	AKT serine/threonine kinase 1	Homo sapiens	98-101	
30106101-0	2018	Oleanolic acid protects against oxidative stress-induced human umbilical vein endothelial cell injury by activating AKT/eNOS signaling.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	116-119	
28880428-0	2017	Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.	Oleanolic Acid	29-43	AKT serine/threonine kinase 1	Homo sapiens	105-108	
32629283-0	2020	Synthesis and antitumor activity of alpha,beta-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway.	Oleanolic Acid	87-101	AKT serine/threonine kinase 1	Homo sapiens	129-132	
31547522-5	2019	Ursolic acid activates AKT/mTOR pathways and oleanolic acid triggers a pathway independent on AKT.	Oleanolic Acid	45-59	AKT serine/threonine kinase 1	Homo sapiens	94-97	
29908114-4	2016	The inhibition effect of oleanolic acid on inflammatory factors stimulated by IL-1beta may be worked through MAPK, PI3K/Akt and NF-kappaB signaling pathways.	Oleanolic Acid	25-39	AKT serine/threonine kinase 1	Homo sapiens	120-123	
27162477-0	2016	Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	88-91	
26687646-0	2016	Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	119-122	
26823699-0	2015	Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	71-74	
26823699-5	2015	Furthermore, Akt, mTOR and S6K protein expression was greatly inhibited in T24 cells under oleanolic acid treatment.	Oleanolic Acid	91-105	AKT serine/threonine kinase 1	Homo sapiens	13-16	
26823699-7	2015	Taken together, we provided evidences that oleanolic acid was Akt/mTOR/S6K and ERK1/2 signaling-targeting anti-tumor agent.	Oleanolic Acid	43-57	AKT serine/threonine kinase 1	Homo sapiens	62-65	
26823699-8	2015	These findings represent new evidences that oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling, and oleanolic acid may be used to prevent human bladder cancer.	Oleanolic Acid	44-58	AKT serine/threonine kinase 1	Homo sapiens	115-118	
24824325-0	2014	Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	52-55	
24728886-0	2015	Oleanolic acid derivatives induce apoptosis in human leukemia K562 cell involved in inhibition of both Akt1 translocation and pAkt1 expression.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	103-107	
18778688-2	2008	Here we identified a new oleanolic acid derivative, 3-beta-(2-carboxybenzoyloxy)-oleanolic acid (NPLC441), which functioned as a competitive PTP1B inhibitor and enhanced insulin-stimulated phosphorylation of IR and AKT in HepG2 cells.	Oleanolic Acid	25-39	AKT serine/threonine kinase 1	Homo sapiens	215-218