PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20964318-0 2010 Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B. Oleanolic Acid 39-53 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 83-114 24721313-0 2014 Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors. Oleanolic Acid 36-50 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 70-101 24721313-1 2014 Sixteen novel oleanolic acid triterpenoid saponins were synthesized in an efficient and practical strategy, and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-cell protein tyrosine phosphatase (TCPTP) were evaluated in vitro. Oleanolic Acid 14-28 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 148-179 24721313-1 2014 Sixteen novel oleanolic acid triterpenoid saponins were synthesized in an efficient and practical strategy, and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-cell protein tyrosine phosphatase (TCPTP) were evaluated in vitro. Oleanolic Acid 14-28 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 181-186 23531458-0 2013 Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors. Oleanolic Acid 39-53 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 69-74 23531458-1 2013 Twenty-four sugar-substituted oleanolic acid derivatives (1a-1f, 2a-2j, and 3a-3h) were synthesized in a concise and efficient strategy and their effects on the inhibition of protein tyrosine phosphatase 1B (PTP1B) and insulin-sensitizing response were evaluated in vitro. Oleanolic Acid 30-44 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 175-206 23531458-1 2013 Twenty-four sugar-substituted oleanolic acid derivatives (1a-1f, 2a-2j, and 3a-3h) were synthesized in a concise and efficient strategy and their effects on the inhibition of protein tyrosine phosphatase 1B (PTP1B) and insulin-sensitizing response were evaluated in vitro. Oleanolic Acid 30-44 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 208-213 23531458-4 2013 Structure-activity relationship study of these sugar-substituted oleanolic acid derivatives demonstrated that PTP1B inhibitory activity and insulin-sensitizing response were strongly influenced by both the carbohydrate moiety at the C-3 position and the long acidic chain at C-28 position of oleanolic acid. Oleanolic Acid 65-79 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 110-115 23531458-4 2013 Structure-activity relationship study of these sugar-substituted oleanolic acid derivatives demonstrated that PTP1B inhibitory activity and insulin-sensitizing response were strongly influenced by both the carbohydrate moiety at the C-3 position and the long acidic chain at C-28 position of oleanolic acid. Oleanolic Acid 292-306 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 110-115 27373628-7 2016 Oleanolic acid, a positive control, inhibited PTP1B activity at 0.7+-0.1 microM (IC50) in the same experiment. Oleanolic Acid 0-14 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 46-51 26253631-4 2015 Oleanolic acid, a positive control, inhibited PTP1B activity at 0.7 muM (IC50). Oleanolic Acid 0-14 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 46-51 25264584-0 2014 Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition. Oleanolic Acid 13-27 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 85-91 25264584-2 2014 Pentacyclic acid triterpenes such as oleanolic acid (OA) have proved to be excellent PTP-1B inhibitors, thus, the purpose of current work was to generate a series of derivatives that improve the pharmacological effect of OA. Oleanolic Acid 37-51 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 85-91 25264584-2 2014 Pentacyclic acid triterpenes such as oleanolic acid (OA) have proved to be excellent PTP-1B inhibitors, thus, the purpose of current work was to generate a series of derivatives that improve the pharmacological effect of OA. Oleanolic Acid 53-55 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 85-91 20964318-2 2010 Derivatives of oleanolic acid were synthesized and evaluated as PTP1B inhibitors. Oleanolic Acid 15-29 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 64-69 31742469-2 2020 In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. Oleanolic Acid 50-52 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 75-80 18778688-2 2008 Here we identified a new oleanolic acid derivative, 3-beta-(2-carboxybenzoyloxy)-oleanolic acid (NPLC441), which functioned as a competitive PTP1B inhibitor and enhanced insulin-stimulated phosphorylation of IR and AKT in HepG2 cells. Oleanolic Acid 25-39 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 141-146 31742469-2 2020 In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. Oleanolic Acid 34-48 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 75-80 31743023-10 2019 Cya-3-Ara could also be regarded as a synergistic inhibitor (CI <= 0.54) of oleanolic acid to obtain a better inhibitory effect on PTP1B. Oleanolic Acid 79-93 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 134-139