PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26297978-0 2015 Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 104-108 24559268-0 2014 Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling. Oleanolic Acid 23-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 121-125 25280775-0 2015 Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. Oleanolic Acid 54-68 nuclear factor, erythroid derived 2, like 2 Mus musculus 78-82 25280775-1 2015 This study utilized pharmacological activation of Nrf2 with oleanolic acid (OA, 22.5mg/kg, sc for 4 days) and the genetic alteration of Nrf2 (Nrf2-null, wild-type, and Keap1-HKO mice) to examine the role of Nrf2 in protection against phalloidin hepatotoxicity. Oleanolic Acid 60-74 nuclear factor, erythroid derived 2, like 2 Mus musculus 50-54 24393202-0 2014 Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132 24393202-9 2014 Oleanolic acid increased the expression of nuclear Nrf2, heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and heat shock protein 70, and decreased lipid peroxidation in the obstructed kidney of UUO mice. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 51-55 24393202-10 2014 There were no changes in the expression of total Nrf2 and Kelch-like ECH-associated protein 1, indicating that oleanolic acid enhanced nuclear translocation of Nrf2. Oleanolic Acid 111-125 nuclear factor, erythroid derived 2, like 2 Mus musculus 160-164 24393202-11 2014 CONCLUSIONS: These results suggest that oleanolic acid may exert beneficial effects on renal fibrosis by increasing nuclear translocation of Nrf2 and subsequently reducing renal oxidative stress. Oleanolic Acid 40-54 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-145 24559268-2 2014 This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury. Oleanolic Acid 76-90 nuclear factor, erythroid derived 2, like 2 Mus musculus 48-52 24559268-2 2014 This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury. Oleanolic Acid 76-90 nuclear factor, erythroid derived 2, like 2 Mus musculus 124-128 24559268-2 2014 This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury. Oleanolic Acid 92-94 nuclear factor, erythroid derived 2, like 2 Mus musculus 48-52 24559268-2 2014 This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury. Oleanolic Acid 92-94 nuclear factor, erythroid derived 2, like 2 Mus musculus 124-128 18706400-0 2008 New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Oleanolic Acid 58-72 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-111 24606795-41 2014 Other strategies include the triggering of Nrf2/antioxidant response element (ARE) pathway by triterpenoids (derivatives of oleanolic acid) or by Bacopa monniera, the enhancement of ATP production by carnitine and -lipoic acid. Oleanolic Acid 124-138 nuclear factor, erythroid derived 2, like 2 Mus musculus 43-47 19283895-0 2009 Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 25-29 19283895-0 2009 Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 81-85 19283895-0 2009 Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 81-85 19283895-2 2009 In order to determine whether oleanolic acid activates nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with oleanolic acid (90 mg/kg, i.p.) Oleanolic Acid 30-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 55-98 19283895-2 2009 In order to determine whether oleanolic acid activates nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with oleanolic acid (90 mg/kg, i.p.) Oleanolic Acid 30-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 100-104 19283895-4 2009 Oleanolic acid increased nuclear accumulation of Nrf2 in wild-type but not Nrf2-null mice, as determined by Western blot and immunofluorescence. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 49-53 19283895-5 2009 Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-87 19283895-5 2009 Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 231-235 19283895-6 2009 In addition, oleanolic acid increased protein expression and enzyme activity of the prototypical Nrf2 target gene, Nqo1, in wild-type, but not in Nrf2-null mice. Oleanolic Acid 13-27 nuclear factor, erythroid derived 2, like 2 Mus musculus 97-101 19283895-7 2009 Oleanolic acid protected against acetaminophen hepatotoxicity in wild-type mice but to a lesser extent in Nrf2-null mice. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 106-110 19283895-8 2009 Oleanolic acid-mediated Nrf2-independent protection from acetaminophen is, in part, due to induction of Nrf2-independent cytoprotective genes, such as metallothionein. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 24-28 19283895-8 2009 Oleanolic acid-mediated Nrf2-independent protection from acetaminophen is, in part, due to induction of Nrf2-independent cytoprotective genes, such as metallothionein. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 104-108 19283895-9 2009 Collectively, the present study demonstrates that oleanolic acid facilitates Nrf2 nuclear accumulation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity. Oleanolic Acid 50-64 nuclear factor, erythroid derived 2, like 2 Mus musculus 77-81 19283895-9 2009 Collectively, the present study demonstrates that oleanolic acid facilitates Nrf2 nuclear accumulation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity. Oleanolic Acid 50-64 nuclear factor, erythroid derived 2, like 2 Mus musculus 125-129 23489687-0 2013 Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis: crucial role of ERK-NRF2 signaling pathway. Oleanolic Acid 21-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 115-119 31248593-2 2019 Bardoxolone (Bard), a synthetic triterpenoid based on natural product oleanolic acid, is one of the most potent Nrf2 activator. Oleanolic Acid 70-84 nuclear factor, erythroid derived 2, like 2 Mus musculus 112-116 29973206-2 2018 Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with unilateral ureteral obstruction. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 37-59 29973206-2 2018 Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with unilateral ureteral obstruction. Oleanolic Acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 61-65