PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31611795-0 2019 Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR. Oleanolic Acid 0-14 nuclear receptor subfamily 1 group I member 2 Homo sapiens 86-89 31611795-6 2019 Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR. Oleanolic Acid 25-27 nuclear receptor subfamily 1 group I member 2 Homo sapiens 149-152 31611795-8 2019 A dual-luciferase reporter assay showed that OA and UA could markedly promote PXR-mediated UGT1A1 luciferase activity, whereas OA and UA did not affect CAR-mediated UGT1A1 luciferase activity. Oleanolic Acid 45-47 nuclear receptor subfamily 1 group I member 2 Homo sapiens 78-81 31611795-11 2019 Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR. Oleanolic Acid 13-15 nuclear receptor subfamily 1 group I member 2 Homo sapiens 158-161 30351048-0 2018 Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis. Oleanolic Acid 0-14 nuclear receptor subfamily 1 group I member 2 Homo sapiens 51-70 28945086-0 2017 Oleanolic Acid-Mediated Inhibition of Pregnane X Receptor and Constitutive Androstane Receptor Attenuates Rifampin-Isoniazid Cytotoxicity. Oleanolic Acid 0-14 nuclear receptor subfamily 1 group I member 2 Homo sapiens 38-57 28945086-3 2017 Here, we aimed to determine the antagonistic effect of oleanolic acid (OA) on PXR and CAR. Oleanolic Acid 55-69 nuclear receptor subfamily 1 group I member 2 Homo sapiens 78-81 28945086-3 2017 Here, we aimed to determine the antagonistic effect of oleanolic acid (OA) on PXR and CAR. Oleanolic Acid 71-73 nuclear receptor subfamily 1 group I member 2 Homo sapiens 78-81