PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27417252-7 2016 Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance. Oleanolic Acid 157-171 aldo-keto reductase family 1 member B10 Homo sapiens 32-39 27417252-7 2016 Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance. Oleanolic Acid 157-171 aldo-keto reductase family 1 member B10 Homo sapiens 139-146 27417252-7 2016 Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance. Oleanolic Acid 157-171 aldo-keto reductase family 1 member B10 Homo sapiens 139-146 25304374-6 2014 Inhibition of AKR1B10 by oleanolic acid (OA) showed a dose-dependent inhibition of cell growth with IC50 at 30 microM. Oleanolic Acid 25-39 aldo-keto reductase family 1 member B10 Homo sapiens 14-21 21561086-4 2011 Among them, oleanolic acid (1) was found to be the most potent competitive inhibitor (inhibition constant, 72 nM) with the highest AKR1B10/AKR1B1 selectivity ratio of 1370. Oleanolic Acid 12-26 aldo-keto reductase family 1 member B10 Homo sapiens 131-138 21561086-6 2011 Oleanolic acid (1) also inhibited the cellular metabolism by AKR1B10 (IC(50), 4 muM) and decreased mitomycin C tolerance of colon cancer HT29 cells. Oleanolic Acid 0-14 aldo-keto reductase family 1 member B10 Homo sapiens 61-68 34035231-8 2021 Consistently, AKR1B10 overexpression induced cancer cell aggressiveness, whereas suppression of AKR1B10 by siRNA or its small molecular inhibitor, oleanolic acid, reversed the CBX7 deficiency-induced cellular effects. Oleanolic Acid 147-161 aldo-keto reductase family 1 member B10 Homo sapiens 96-103