PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23138847-4 2013 Moreover, the DHA treatment dramatically increased the protein expression of caspase-8, cleaved caspase-9, activated Bid and induced the release of cytochrome c from mitochondria into the cytosol. artenimol 14-17 caspase 8 Homo sapiens 77-86 34876259-0 2022 Corrigendum to "Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma" (Chem. artenimol 16-34 caspase 8 Homo sapiens 50-61 34655567-0 2021 Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma. artenimol 0-18 caspase 8 Homo sapiens 34-45 34655567-4 2021 After applying DHA treatment to ESCC, we found that some dying cells exhibited the characteristic morphology of pyroptosis, such as blowing large bubbles from the cell membrane, accompanied by downregulation of pyruvate kinase isoform M2 (PKM2), activation of caspase-8/3, and production of GSDME-NT. artenimol 15-18 caspase 8 Homo sapiens 260-271 34655567-6 2021 Both knockdown of GSDME and application of caspase-8/3 specific inhibitors (z-ITED-FMK/Ac-DEVD-CHO) significantly inhibited DHA-induced pyroptosis. artenimol 124-127 caspase 8 Homo sapiens 43-54 34655567-10 2021 Therefore, the results suggest that DHA can induce pyroptosis of ESCC cells via the PKM2-caspase-8/3-GSDME pathway. artenimol 36-39 caspase 8 Homo sapiens 89-100 33596797-6 2022 RESULTS: DHA effectively inhibited the proliferation, invasion, and migration of SGC7901/DDP cells and induced cell apoptosis which was accompanied by caspase-8/9/3 activation. artenimol 9-12 caspase 8 Homo sapiens 151-164 33596797-9 2022 CONCLUSION: DHA exerts an anti-cancer effect on SGC7901/DDP cells and the mechanisms possibly include enhancement of autophagy via PI3K/AKT/mTOR inhibition, inducement of apoptosis through caspase-dependent and mitochondrial pathway, and enhancement of cisplatin sensitivity through P-gp inhibition. artenimol 12-15 caspase 8 Homo sapiens 189-196 31534470-9 2019 DHA treatment significantly upregulated the apoptotic genes CASP3, CASP8, CASP9, and TNF. artenimol 0-3 caspase 8 Homo sapiens 67-72 28182780-4 2017 Pretreatment with Z-IETD-FMK (caspase-8 inhibitor) potently prevented the cytotoxicity of the combination treatment of DHA/ARS and FTS, and pretreatment with Z-VAD-FMK (pan-caspase inhibitor) significantly inhibited the loss of DeltaPsim induced by DHA/ARS treatment or the combination treatment of DHA/ARS and FTS in HCC cells. artenimol 119-122 caspase 8 Homo sapiens 30-39 24519064-6 2014 We also found that DHA decreased the mitochondrial membrane potential; activated the caspase-3, caspase-8, and caspase-9; and increased the ratio of Bax/Bcl-2. artenimol 19-22 caspase 8 Homo sapiens 96-105 24337869-6 2014 Collectively, the present study demonstrates a strong synergistic action of the combined treatment with Gem and DHA in inducing apoptosis of A549 cells via both the Bak-mediated intrinsic pathway and the Fas-caspase-8-mediated extrinsic pathway. artenimol 112-115 caspase 8 Homo sapiens 208-217 29128513-10 2018 DHA activated caspase 3, caspase 8, and caspase 9 and cleaved poly (ADP-ribose) polymerase (PARP). artenimol 0-3 caspase 8 Homo sapiens 25-34 29128513-11 2018 DHA-induced apoptotic cell death, activation of caspases and cleavage of PARP were dramatically inhibited by pan caspase inhibitor Z-VAD-FMK. artenimol 0-3 caspase 8 Homo sapiens 48-56 25018064-1 2014 Our recent studies have demonstrated the key roles of reactive oxygen species (ROS)-mediated caspase-8- and Bax-dependent apoptotic pathways in dihydroartemisinin (DHA)-induced apoptosis of A549 cells. artenimol 144-162 caspase 8 Homo sapiens 93-102 25018064-1 2014 Our recent studies have demonstrated the key roles of reactive oxygen species (ROS)-mediated caspase-8- and Bax-dependent apoptotic pathways in dihydroartemisinin (DHA)-induced apoptosis of A549 cells. artenimol 164-167 caspase 8 Homo sapiens 93-102 25018064-7 2014 Furthermore, NAC pretreatment potently prevented DHA-induced ROS generation and loss of DeltaPsim as well as apoptosis, and silencing Bax by shRNA or inhibition of one of caspase-3, -8 and -9 also significantly prevented DHA-induced apoptosis in both cell lines, indicating the key roles of ROS and Bax as well as the caspases. artenimol 49-52 caspase 8 Homo sapiens 318-326 25018064-8 2014 Collectively, DHA presents more potent proapoptotic actions in A549GR cells preferentially over normal A549 cells via ROS-dependent apoptotic pathway, in which Bax and caspases are involved. artenimol 14-17 caspase 8 Homo sapiens 168-176 23536891-0 2013 Ionizing radiation potentiates dihydroartemisinin-induced apoptosis of A549 cells via a caspase-8-dependent pathway. artenimol 31-49 caspase 8 Homo sapiens 88-97 23536891-2 2013 DHA treatment induced a concentration- and time-dependent reactive oxygen species (ROS)-mediated cell death with typical apoptotic characteristics such as breakdown of mitochondrial membrane potential (Deltapsim), caspases activation, DNA fragmentation and phosphatidylserine (PS) externalization. artenimol 0-3 caspase 8 Homo sapiens 214-222 23536891-3 2013 Inhibition of caspase-8 or -9 significantly blocked DHA-induced decrease of cell viability and activation of caspase-3, suggesting the dominant roles of caspase-8 and -9 in DHA-induced apoptosis. artenimol 52-55 caspase 8 Homo sapiens 14-23 23536891-3 2013 Inhibition of caspase-8 or -9 significantly blocked DHA-induced decrease of cell viability and activation of caspase-3, suggesting the dominant roles of caspase-8 and -9 in DHA-induced apoptosis. artenimol 52-55 caspase 8 Homo sapiens 153-169 23536891-3 2013 Inhibition of caspase-8 or -9 significantly blocked DHA-induced decrease of cell viability and activation of caspase-3, suggesting the dominant roles of caspase-8 and -9 in DHA-induced apoptosis. artenimol 173-176 caspase 8 Homo sapiens 14-23 23536891-3 2013 Inhibition of caspase-8 or -9 significantly blocked DHA-induced decrease of cell viability and activation of caspase-3, suggesting the dominant roles of caspase-8 and -9 in DHA-induced apoptosis. artenimol 173-176 caspase 8 Homo sapiens 153-169 23536891-7 2013 More importantly, IR synergistically potentiated DHA-induced generation of ROS, activation of caspase-8 and -3, irreparable G2/M arrest and apoptosis, but did not enhance DHA-induced loss of Deltapsim and activation of caspase-9. artenimol 49-52 caspase 8 Homo sapiens 94-110 23536891-8 2013 Taken together, our results strongly demonstrate the remarkable synergistic efficacy of combination treatment with DHA and low-dose IR for A549 cells in which IR potentiates DHA-induced apoptosis largely by enhancing the caspase-8-mediated extrinsic pathway. artenimol 115-118 caspase 8 Homo sapiens 221-230 23536891-8 2013 Taken together, our results strongly demonstrate the remarkable synergistic efficacy of combination treatment with DHA and low-dose IR for A549 cells in which IR potentiates DHA-induced apoptosis largely by enhancing the caspase-8-mediated extrinsic pathway. artenimol 174-177 caspase 8 Homo sapiens 221-230 22342732-5 2012 DHA-induced apoptosis was associated with mitochondrial membrane depolarization, release of cytochrome c, activation of caspases, and DNA fragmentation. artenimol 0-3 caspase 8 Homo sapiens 120-128 22994042-4 2012 RESULTS: Compared with the 0 micromol/L control group, the 25, 50 and 100 micromol/L dihydroartemisinin groups showed significantly increased apoptosis of PC-3M cells ([2.92 +/- 0.45]% vs [8.85 +/- 0.74]%, [12.83 +/- 0.84]% and [18.65 +/- 1.24]%, P < 0.01), and dose-dependent increase in the activities of caspase-8 ([0.47 +/- 0.05 ] U/microg vs [1.22 +/- 0.15], [1.76 +/- 0.07] and [2.91 +/- 0.24] U/microg, P < 0.01) and caspase-3 ([0.44 +/- 0.07] U/microg vs [0.95 +/- 0.08], [1.48 +/- 0.14] and [2.92 +/- 0.45] U/microg, P < 0.01). artenimol 85-103 caspase 8 Homo sapiens 310-319 21234653-9 2011 Mechanistically, DHA activated caspase-3, caspase-8, and caspase-9; upregulated the expression of Bax, FAS, and cyclin D1; downregulated the expression of Bcl-2, Cdc25B, and cyclin B1; and inhibited the activity of NF-kB. artenimol 17-20 caspase 8 Homo sapiens 42-51 20663933-2 2010 Treatment of Jurkat T-lymphoma cells with DHA induced a breakdown of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases, and DNA fragmentation indicative of apoptosis induction. artenimol 42-45 caspase 8 Homo sapiens 151-159 20799830-0 2010 Single-cell analysis of dihydroartemisinin-induced apoptosis through reactive oxygen species-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques. artenimol 24-42 caspase 8 Homo sapiens 102-111 20799830-6 2010 Confocal imaging analysis in a single living cell and Western blot assay showed that DHA triggered ROS-dependent Bax translocation, mitochondrial membrane depolarization, alteration of mitochondrial morphology, cytochrome c release, caspase-9, caspase-8, and caspase-3 activation, indicating the coexistence of ROS-mediated mitochondrial and death receptor pathway. artenimol 85-88 caspase 8 Homo sapiens 244-253 20799830-7 2010 Collectively, our findings demonstrate for the first time that DHA induces cell apoptosis by triggering ROS-mediated caspase-8/Bid activation and the mitochondrial pathway, which provides some novel insights into the application of DHA as a potential anticancer drug and a new therapeutic strategy by targeting ROS signaling in lung adenocarcinoma therapy in the future. artenimol 63-66 caspase 8 Homo sapiens 117-126 20799830-7 2010 Collectively, our findings demonstrate for the first time that DHA induces cell apoptosis by triggering ROS-mediated caspase-8/Bid activation and the mitochondrial pathway, which provides some novel insights into the application of DHA as a potential anticancer drug and a new therapeutic strategy by targeting ROS signaling in lung adenocarcinoma therapy in the future. artenimol 232-235 caspase 8 Homo sapiens 117-126