PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34531546-5 2021 Pretreatment with an SIRT1 inhibitor selisistat (SELI, 10 muM) attenuated the neuroprotection of ROF, ROF-reduced expression of alpha-syn, and ROF-increased expression levels of LAMP1 and mature CTSD. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 37-47 sirtuin 1 Mus musculus 21-26 33798807-8 2021 However, EX527, a SIRT1 inhibitor, blocked the protective effect of curcumin against ALI. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 9-14 sirtuin 1 Mus musculus 18-23 33034242-8 2020 Moreover, Sirt1-specific inhibitor Ex527 administration abolished the anti-inflammatory and anti-macrophage M1 polarization effects of loganin in UC. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 35-40 sirtuin 1 Mus musculus 10-15 34738708-7 2022 The resultant attenuation of DRP1-mediated mitochondrial fragmentation in RSV-pretreated mice was abolished by the addition of the SIRT1 inhibitor EX527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 147-152 sirtuin 1 Mus musculus 131-136 34970875-4 2021 Mice of the EA +inhibitor group received intraperitoneal injection of SIRT1 inhibitor EX527 (5 mg/kg) at the same time of EA treatment, and those of the agonist group received gavage of resveratrol (200 mg/kg, an agonist of SIRT1), 3 times a week for 11 weeks. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 86-91 sirtuin 1 Mus musculus 70-75 34853445-7 2021 Notably, the therapeutic effect of DAPA was weakened by pretreatment with the SIRT1 inhibitor EX527 (10 muM). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 94-99 sirtuin 1 Mus musculus 78-83 34665857-6 2022 EX-527, a SIRT1 inhibitor, and SRT1720, a SIRT1 agonist, were also used to evaluate SIRT1 effect on endometriosis. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 0-6 sirtuin 1 Mus musculus 10-15 34665857-12 2022 EX-527 (SIRT1 inhibitor) significantly reduced the number of endometriotic lesions in the mouse endometriosis model. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 0-6 sirtuin 1 Mus musculus 8-13 34174704-11 2021 In addition, EX-527 reversed the therapeutic effect of NAD+ on EAE, suggesting that NAD+ prevented MS-triggered ON by activating the SIRT1 signaling pathway. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 13-19 sirtuin 1 Mus musculus 133-138 34089817-6 2021 The protection was blocked by EX527, a specific SIRT1 inhibitor. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 30-35 sirtuin 1 Mus musculus 48-53 34262905-7 2021 To further explore how SIRT1 mediates the role of GDF11, the selective inhibitor EX527 was used to block SIRT1 signaling pathway, which abolished the protective effects of GDF11 against DCM. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 81-86 sirtuin 1 Mus musculus 23-28 34363008-9 2022 The effect of (R)-TML104 on SIRT1-STAT3 interaction was reversed by treatment with a SIRT1 inhibitor selisistat (EX527). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 101-111 sirtuin 1 Mus musculus 28-33 34363008-9 2022 The effect of (R)-TML104 on SIRT1-STAT3 interaction was reversed by treatment with a SIRT1 inhibitor selisistat (EX527). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 101-111 sirtuin 1 Mus musculus 85-90 34262905-7 2021 To further explore how SIRT1 mediates the role of GDF11, the selective inhibitor EX527 was used to block SIRT1 signaling pathway, which abolished the protective effects of GDF11 against DCM. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 81-86 sirtuin 1 Mus musculus 105-110 35447391-4 2022 Sirt1 selective inhibitor Ex527 and p38 inhibitor SB203580 were used to explore the possible mechanism of PD in SAE. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 26-31 sirtuin 1 Mus musculus 0-5 35090883-11 2022 Notably, EX-527, an inhibitor of SIRT1, reversed the effect of high-dose PT on the optic nerves and retina, indicating that PT exerted the protective effect via activating SIRT1 signaling. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 9-15 sirtuin 1 Mus musculus 33-38 35496289-8 2022 However, SIRT1 inhibitor EX527 reversed the neuroprotection and induced a drop in mitochondrial membrane potential in PTE-treated primary cortical neurons. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 25-30 sirtuin 1 Mus musculus 9-14 35090883-11 2022 Notably, EX-527, an inhibitor of SIRT1, reversed the effect of high-dose PT on the optic nerves and retina, indicating that PT exerted the protective effect via activating SIRT1 signaling. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 9-15 sirtuin 1 Mus musculus 172-177 35419389-9 2022 Similarly, treating undernourished mice with the SIRT1 inhibitor selisistat/EX-527 completely restored hepatic PPARalpha protein. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 65-75 sirtuin 1 Mus musculus 49-54 35419389-9 2022 Similarly, treating undernourished mice with the SIRT1 inhibitor selisistat/EX-527 completely restored hepatic PPARalpha protein. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 76-82 sirtuin 1 Mus musculus 49-54 35090502-12 2022 However, these effects were reversed by the Sirt1 inhibitor EX527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 60-65 sirtuin 1 Mus musculus 44-49 35126819-10 2022 The protective effects of fucoxanthin were significantly reversed by EX527 (a selective inhibitor of Sirt1) or si-Sirt1. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 69-74 sirtuin 1 Mus musculus 101-106 32425778-10 2020 Furthermore, SIRT1 inhibitor EX-527 reduced protection by API against APAP-induced hepatotoxicity. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 29-35 sirtuin 1 Mus musculus 13-18 35123833-10 2022 This protective effect of NMN could be abolished by EX-527, the inhibitor of SIRT1. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 52-58 sirtuin 1 Mus musculus 77-82 34559876-10 2022 Besides, EX-527 (SIRT1 inhibitor) treatment could partially reverse the protective effects of GLP against sepsis-induced cardiac dysfunction (all Ps < 0.01). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 9-15 sirtuin 1 Mus musculus 17-22 34029668-9 2021 Most importantly, EX527, a potent SIRT1 inhibitor, inactivated SIRT1, which prevented Rsv from exerting its beneficial effects. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 18-23 sirtuin 1 Mus musculus 34-39 34029668-9 2021 Most importantly, EX527, a potent SIRT1 inhibitor, inactivated SIRT1, which prevented Rsv from exerting its beneficial effects. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 18-23 sirtuin 1 Mus musculus 63-68 31393272-6 2020 A selective SIRT1 inhibitor, EX-527, was employed to test for SIRT1 participation in septic cardiac dysfunction. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 29-35 sirtuin 1 Mus musculus 12-17 35109721-7 2022 Intriguingly, these effects could be reversed by the SIRT1 inhibitor EX527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 69-74 sirtuin 1 Mus musculus 53-58 33872698-14 2021 These results were confirmed by antioxidant ALCAR and the Sirt1 inhibitor EX-527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 74-80 sirtuin 1 Mus musculus 58-63 33580874-10 2021 Both EX527 and Cyclosporine A (CsA), which are inhibitors of SIRT1 and mitophagy, markedly alleviated the inhibition of oxidative stress and mitochondrial dysfunction caused by Apelin-36. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 5-10 sirtuin 1 Mus musculus 61-66 33063734-10 2021 Intraperitoneal administration of the Sirt1-specific inhibitor EX527 (5 mg/kg) 30 minutes prior to injury could inhibit the abovementioned effects. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 63-68 sirtuin 1 Mus musculus 38-43 33243606-9 2021 More importantly, the Sirt1 inhibitor, EX527, abolished the inhibitory role of ROF on the production of pro-inflammatory factors, and reactivated BV-2 cells. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 39-44 sirtuin 1 Mus musculus 22-27 33029280-10 2020 Interestingly, pretreatment with SIRT1 inhibitor EX-527 abolished the beneficial effects of BAI against LPS exposure. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 49-55 sirtuin 1 Mus musculus 33-38 32819566-7 2020 Inhibition of SIRT1 activity by EX-527 (a specific inhibitor of SIRT1) totally abolished the suppressive effects of Fastk knockout on gluconeogenesis and lipogenesis in cultured hepatocytes. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 32-38 sirtuin 1 Mus musculus 14-19 32819566-7 2020 Inhibition of SIRT1 activity by EX-527 (a specific inhibitor of SIRT1) totally abolished the suppressive effects of Fastk knockout on gluconeogenesis and lipogenesis in cultured hepatocytes. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 32-38 sirtuin 1 Mus musculus 64-69 32145722-5 2020 This effect was impaired by pretreating the macrophages with 3-methyladenine or wortmannin (selective autophagy inhibitors) or with sirtinol or EX527 (SIRT1 inhibitors). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 144-149 sirtuin 1 Mus musculus 151-156 32217463-4 2020 Treatment with EX527 (a SIRT1 inhibitor) during the early phase and SIRT1 knockout both significantly diminished differentiation to mature adipocytes. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 15-20 sirtuin 1 Mus musculus 24-29 31877320-10 2020 Contrarily, combining use of AICAR and SIRT1 inhibitor (Sirtinol or EX-527) increased SIRT3 level, which led to better alleviation of behavioral disorders, compared with single AICAR treatment. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 68-74 sirtuin 1 Mus musculus 39-44 32110174-7 2020 EX-527 (a SirT1-selective inhibitor) and Sirt1 siRNA were used to demonstrate the Sirt1 dependence of PSPC-mediated effects on apoptotic and survival signaling pathways in vivo and in vitro. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 0-6 sirtuin 1 Mus musculus 82-87 32017914-5 2020 Animals were treated with either taurine for 9 weeks and/or the SIRT1 inhibitor EX527 (5 mg/kg/day, every 2days) after TAC operation. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 80-85 sirtuin 1 Mus musculus 64-69 31068817-7 2019 Pretreatment with EX-527, a SIRT1 inhibitor, abolished the RES-mediated endothelial protection and pro-angiogenesis action, and then delayed diabetic wound healing. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 18-24 sirtuin 1 Mus musculus 28-33 31296380-8 2019 Furthermore, the analgesic effect of miR-34a antagomir was abrogated by the SIRT1 inhibitor EX-527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 92-98 sirtuin 1 Mus musculus 76-81 31450679-6 2019 To explore the role of SIRT1 signaling in melatonin-induced cells, mouse Leydig cells were pretreated with EX527, an inhibitor of SIRT1. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 107-112 sirtuin 1 Mus musculus 130-135 30917412-5 2019 The effect of NR is blocked by the mTORC1 inhibitor rapamycin or the SIRT1 inhibitor EX527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 85-90 sirtuin 1 Mus musculus 69-74 30864731-14 2019 Opposite changes were observed in hypoxic mice treated with the Sirt1 inhibitor EX-527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 80-86 sirtuin 1 Mus musculus 64-69 31430865-8 2019 Interestingly, inhibition of SIRT1 with Ex527 (a potent and selective SIRT1 inhibitor) further enhanced d-gal-induced toxicity and abolished the beneficial effect of 17beta-estradiol. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 40-45 sirtuin 1 Mus musculus 29-34 31430865-8 2019 Interestingly, inhibition of SIRT1 with Ex527 (a potent and selective SIRT1 inhibitor) further enhanced d-gal-induced toxicity and abolished the beneficial effect of 17beta-estradiol. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 40-45 sirtuin 1 Mus musculus 70-75 31497199-7 2019 Results showed that SIRT1 inhibitors (nicotinamide, EX527, salermide and sirtinol), but not SIRT2 inhibitors, significantly improve taste bud organoid survival after IR. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 52-57 sirtuin 1 Mus musculus 20-25 30592048-0 2019 The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 123-133 sirtuin 1 Mus musculus 82-112 30592048-1 2019 OBJECTIVES: To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this effect is prevented by the Silent Information Regulator 1 (SIRT1) inhibitor selisistat. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 214-224 sirtuin 1 Mus musculus 165-195 30592048-1 2019 OBJECTIVES: To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this effect is prevented by the Silent Information Regulator 1 (SIRT1) inhibitor selisistat. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 214-224 sirtuin 1 Mus musculus 197-202 30456702-6 2019 In contrast, treatment with EX-527 (SIRT1 inhibitor) as well as SIRT1 silencing promoted osteoclastogenesis. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 28-34 sirtuin 1 Mus musculus 36-41 30514750-8 2019 Furthermore, we found that administration with a Sirt-1 inhibitor, Ex-527, significantly improved recipient survival and clinical scores, with no signs of tumor relapse. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 67-73 sirtuin 1 Mus musculus 49-55 30691004-5 2019 And the SIRT1 inhibitor EX527 significantly inhibited the effect of cannabisin F on pro-inflammatory cytokines production, suggesting that the anti-inflammatory effects of cannabisin F are SIRT1-dependent. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 24-29 sirtuin 1 Mus musculus 8-13 30691004-5 2019 And the SIRT1 inhibitor EX527 significantly inhibited the effect of cannabisin F on pro-inflammatory cytokines production, suggesting that the anti-inflammatory effects of cannabisin F are SIRT1-dependent. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 24-29 sirtuin 1 Mus musculus 189-194 30523660-7 2019 We also found that AMPKalpha1 siRNA, AMPK inhibitor compound C, or Sirt1 inhibitor EX527 attenuated the positive effect of leucine on slow-twitch muscle fibers and mitochondrial function-related gene expression. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 83-88 sirtuin 1 Mus musculus 67-72 30254426-6 2018 Opposite effects were seen with the SIRT1 inhibitor EX527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 52-57 sirtuin 1 Mus musculus 36-41 28888894-12 2018 In addition, EX527 (SIRT1 inhibitor) reduced the therapeutic effects by exercise. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 13-18 sirtuin 1 Mus musculus 20-25 30186119-15 2018 EX527, an SIRT1 inhibitor, abolished the effects of BML-111. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 0-5 sirtuin 1 Mus musculus 10-15 30071860-7 2018 Cardiomyocytes were exposed to high levels of glucose and were treated with EX-527 (SIRT1 inhibitor). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 76-82 sirtuin 1 Mus musculus 84-89 29752296-8 2018 Furthermore, the protective effect of melatonin on the delay of oocyte aging vanished when the SIRT1 inhibitor EX527 was used to simultaneously treat the oocytes with melatonin. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 111-116 sirtuin 1 Mus musculus 95-100 29067115-10 2017 Furthermore, treatment with Ex527, which is a sirtuin-1 (SIRT1) inhibitor, significantly attenuated the anti-inflammatory effect of resveratrol (P<0.05), and treatment with 5-aminoimidazole-4-carboxamide ribonucleotide, which is a 5" adenosine monophosphate-activated protein kinase (AMPK) activator, resulted in a significant decrease in IL-6 secretion in J774 macrophages (P<0.05). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 28-33 sirtuin 1 Mus musculus 46-55 29354820-6 2018 However, EX-527, an inhibitor of Sirt1, abolished the inhibitory effects of asiatic acid on LPS-stimulated microglia activation. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 9-15 sirtuin 1 Mus musculus 33-38 28952835-0 2017 The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 20-26 sirtuin 1 Mus musculus 4-9 28952835-4 2017 The results indicated that treatment with the selective SIRT1 inhibitor EX-527 suppressed LPS-induced elevation of TNF-alpha and IL-6 in plasma. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 72-78 sirtuin 1 Mus musculus 56-61 29331532-9 2018 When EX-527, a SIRT1 inhibitor, was intraperitoneally injected, we observed anxiolytic effects in the CD-fed mice but not in the 12-week HFD-fed mice. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 5-11 sirtuin 1 Mus musculus 15-20 28940469-7 2018 Notably, the autophagy-reducing effect of xanthohumol was abolished after the addition of Ex527, a selective inhibitor of sirtuin 1, suggesting that xanthohumol is an effective sirtuin 1 activator for reducing autophagy. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 90-95 sirtuin 1 Mus musculus 122-131 28940469-7 2018 Notably, the autophagy-reducing effect of xanthohumol was abolished after the addition of Ex527, a selective inhibitor of sirtuin 1, suggesting that xanthohumol is an effective sirtuin 1 activator for reducing autophagy. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 90-95 sirtuin 1 Mus musculus 177-186 29185343-6 2017 Indeed, treatment with a SIRT1 selective inhibitor, EX-527, hampered the ability of PQQ to stimulate PGC-1alpha-mediated mitochondrial biogenesis. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 52-58 sirtuin 1 Mus musculus 25-30 28888780-7 2017 Consistently, the inhibitory effects of BBR on proinflammatory cytokines expression was largely abrogated by Sirt1 inhibition either by EX527, a Sirt1 inhibitor or Sirt1 siRNA. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 136-141 sirtuin 1 Mus musculus 109-114 29067115-10 2017 Furthermore, treatment with Ex527, which is a sirtuin-1 (SIRT1) inhibitor, significantly attenuated the anti-inflammatory effect of resveratrol (P<0.05), and treatment with 5-aminoimidazole-4-carboxamide ribonucleotide, which is a 5" adenosine monophosphate-activated protein kinase (AMPK) activator, resulted in a significant decrease in IL-6 secretion in J774 macrophages (P<0.05). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 28-33 sirtuin 1 Mus musculus 57-62 28493611-7 2017 However, the effects of FO were significantly reversed by EX527, a specific Sirt-1 inhibitor. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 58-63 sirtuin 1 Mus musculus 76-82 27670404-5 2017 The Sirt1 inhibitor Ex-527 curtailed the genistein-mediated increase in UCP1 and Cebpbeta mRNA, revealing a role for Sirt1 in mediating the effect. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 20-26 sirtuin 1 Mus musculus 4-9 28881659-8 2017 Additionally, the application of the SIRT1 inhibitor EX-527 or SIRT1 siRNA further attenuated ox-LDL-induced autophagy inhibition. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 53-59 sirtuin 1 Mus musculus 37-42 28449683-12 2017 Furthermore, Resveratrol, a Sirt1 activator, significantly reduced lipogenic gene expressions, while EX-527, a Sirt1 specific inhibitor, had the opposite effects. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 101-107 sirtuin 1 Mus musculus 111-116 27670404-5 2017 The Sirt1 inhibitor Ex-527 curtailed the genistein-mediated increase in UCP1 and Cebpbeta mRNA, revealing a role for Sirt1 in mediating the effect. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 20-26 sirtuin 1 Mus musculus 117-122 25631045-7 2015 In contrast, the SIRT1 inhibitor, EX527, significantly enhanced PTH-induced Mmp13 expression. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 34-39 sirtuin 1 Mus musculus 17-22 27564107-8 2016 When SIRT1 inhibitor Ex-527 was used, the latter effects were reversed. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 21-27 sirtuin 1 Mus musculus 5-10 27339462-10 2016 Depletion of SIRT1 by knockdown or SIRT1 inhibitor EX527 abrogated the antisenescence effect of alpha7nAChR against Ang II. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 51-56 sirtuin 1 Mus musculus 35-40 26299770-2 2015 We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in a mouse model of lethal-cecal-ligationand- puncture (CLP)-induced septic shock. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 30-36 sirtuin 1 Mus musculus 54-59 25401748-5 2015 Prior to this procedure, the mice were given intraperitoneal with or without the SIRT1 inhibitor, EX527. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 98-103 sirtuin 1 Mus musculus 81-86 20851107-5 2010 However, we found that although Sirt1 protein was abundantly expressed in RAW264.7 cells, the specific Sirt1 inhibitor EX-527 could not attenuate the inhibition of osteoclastogenesis mediated by resveratrol. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 119-125 sirtuin 1 Mus musculus 103-108 25051385-3 2014 The aims of the present study were to explore the effect of EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, on survival in the lethal model of CLP-sepsis and to assess the impact of the treatment on inflammatory cytokine production, coagulopathy, and bone marrow atrophy during severe sepsis. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 60-66 sirtuin 1 Mus musculus 80-89 25051385-3 2014 The aims of the present study were to explore the effect of EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, on survival in the lethal model of CLP-sepsis and to assess the impact of the treatment on inflammatory cytokine production, coagulopathy, and bone marrow atrophy during severe sepsis. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 60-66 sirtuin 1 Mus musculus 91-96 25001863-6 2014 We tested this concept in septic mice, using the highly specific SIRT1 inhibitor EX-527, a small molecule that closes the NAD+ binding site of SIRT1. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 81-87 sirtuin 1 Mus musculus 65-70 25001863-6 2014 We tested this concept in septic mice, using the highly specific SIRT1 inhibitor EX-527, a small molecule that closes the NAD+ binding site of SIRT1. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 81-87 sirtuin 1 Mus musculus 143-148 24959710-6 2014 Finally, we investigated whether SIRT1 inhibitor EX-527 could reverse the anti-nociceptive effect of NAD or resveratrol. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 49-55 sirtuin 1 Mus musculus 33-38 24946089-6 2014 At variance with other sirtuin modulators (sirtinol, AGK2 and SRT1720), the well-known SIRT1 inhibitor Ex527 has positive effects on survival of neuronal cells expressing mutant SOD1, but this effect is neither mediated by SIRT1 inhibition nor by SIRT2 inhibition. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 103-108 sirtuin 1 Mus musculus 87-92 24946089-6 2014 At variance with other sirtuin modulators (sirtinol, AGK2 and SRT1720), the well-known SIRT1 inhibitor Ex527 has positive effects on survival of neuronal cells expressing mutant SOD1, but this effect is neither mediated by SIRT1 inhibition nor by SIRT2 inhibition. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 103-108 sirtuin 1 Mus musculus 223-228 23778143-5 2013 Furthermore, treatment with a pan-sirtuin inhibitor (nicotinamide) or a SIRT1-specific inhibitor (EX-527) delayed cyst growth in Pkd1 knockout mouse embryonic kidneys, Pkd1 conditional knockout postnatal kidneys, and Pkd1 hypomorphic kidneys. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 98-104 sirtuin 1 Mus musculus 72-77 22447223-12 2012 Sirt1 activator resveratrol (10 mumol/L) mimicked the protection of the cells by Sirt1 overexpression against TNF-alpha-induced injury, which was reversed by the Sirt1 inhibitor EX-527 (5 mumol/L). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 178-184 sirtuin 1 Mus musculus 0-5 22447223-12 2012 Sirt1 activator resveratrol (10 mumol/L) mimicked the protection of the cells by Sirt1 overexpression against TNF-alpha-induced injury, which was reversed by the Sirt1 inhibitor EX-527 (5 mumol/L). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 178-184 sirtuin 1 Mus musculus 81-86 22447223-12 2012 Sirt1 activator resveratrol (10 mumol/L) mimicked the protection of the cells by Sirt1 overexpression against TNF-alpha-induced injury, which was reversed by the Sirt1 inhibitor EX-527 (5 mumol/L). 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 178-184 sirtuin 1 Mus musculus 81-86 21199917-7 2011 Comparable results were seen in wild-type allograft recipients treated with Sirt1 inhibitors, such as EX-527 and splitomicin. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 102-108 sirtuin 1 Mus musculus 76-81 22312127-6 2012 Acetylation and stability of wild-type, but not mutant, Foxp3 is enhanced when cells are treated with Ex-527, an inhibitor of the NAD(+)-dependent deacetylase SIRT1. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 102-108 sirtuin 1 Mus musculus 159-164 18850005-4 2009 We show that SIRT1 deacetylates cortactin in vivo and in vitro and that the SIRT1 inhibitor EX-527 increases amounts of acetylated cortactin in ovarian cancer cells. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 92-98 sirtuin 1 Mus musculus 76-81 20810901-4 2010 When a Sirt1 inhibitor (EX-527) was injected either peripherally (i.p., 10 mg/kg) or directly into the brain (i.c.v., 1.5 nmol/mouse), it decreased both food intake during the dark cycle and ghrelin-induced food intake. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 24-30 sirtuin 1 Mus musculus 7-12