PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33453147-7 2021 H2 O2 , an enzymatic product of VAP-1, which promoted the production of IL-4 by mouse Th2 and inhibited IFN-gamma by mouse Th1 and human tumor-infiltrating lymphocytes, was decreased in tumors and CD31+ tumor vascular endothelial cells in the TMEs of mice treated with VAP-1 inhibitor. th2 86-89 interleukin 4 Mus musculus 72-76 32667158-7 2021 In the analysis of the humoral immune response, AJ-Ang II mainly elicited IgG1 antibodies and IL-4 and IL-10 production, as measured by an enzyme-linked immune absorbent spot assay, which suggests the induction of a Th2 response. th2 216-219 interleukin 4 Mus musculus 94-98 33337558-7 2021 Following injection of AChE-edited schistosome eggs into the tail veins of mice, an significantly enhanced Th2 response involving IL-4, -5, -10, and-13 was detected in lung cells and splenocytes in mice injected with X5-KI eggs in comparison to control mice injected with unmutated eggs. th2 107-110 interleukin 4 Mus musculus 130-151 33337558-8 2021 A Th2-predominant response, with increased levels of IL-4, -13, and GATA3, also was induced by X5 KI eggs in small intestine-draining mesenteric lymph node cells when the gene-edited eggs were introduced into the subserosa of the ileum of the mice. th2 2-5 interleukin 4 Mus musculus 53-62 32880064-2 2020 Therefore, development of a therapeutic approach against IL-4 signaling is expected to prevent or control Th2-related allergic diseases. th2 106-109 interleukin 4 Mus musculus 57-61 31434203-11 2019 These findings suggest that IL-4 mediates IL-31RA expression and IL-31/IL-31RA interaction augments Ccl 17 and Ccl 22 production in BMDCs, which promotes Th2-deviated immune response in AD. th2 154-157 interleukin 4 Mus musculus 28-32 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 90-93 interleukin 4 Mus musculus 43-47 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 122-125 interleukin 4 Mus musculus 43-47 30715796-13 2019 CONCLUSION: Survivin facilitates the development of biased Th2 polarization through promoting expression of interleukin 4 (IL-4) and impairing the AICD machinery of CD4+ T cells. th2 59-62 interleukin 4 Mus musculus 108-121 30715796-13 2019 CONCLUSION: Survivin facilitates the development of biased Th2 polarization through promoting expression of interleukin 4 (IL-4) and impairing the AICD machinery of CD4+ T cells. th2 59-62 interleukin 4 Mus musculus 123-127 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 interleukin 4 Mus musculus 102-106 27315109-6 2016 More importantly, Th2-promoting adjuvant activities by alum found in IL-4 knockout mice were also largely reduced when basophils were depleted by antibody administration. th2 18-21 interleukin 4 Mus musculus 69-73 27315109-7 2016 Therefore, basophils can mediate Th2-promoting activities by alum both in vitro and in vivo through IL-4-independent mechanisms. th2 33-36 interleukin 4 Mus musculus 100-104 14500660-4 2003 Stat6 is the protein activated by signal transduction through the IL-4R, and studies with knockout mice demonstrate that Stat6 is critical for a number of IL-4-mediated functions including Th2 development and production of IgE. th2 189-192 interleukin 4 Mus musculus 66-70 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 interleukin 4 Mus musculus 248-252 10375450-12 1999 In conclusion, a Th2-induced mouse conjunctival eosinophilia model was established in which D10 activation results in IL-4 and IL-5 release. th2 17-20 interleukin 4 Mus musculus 118-122 9257851-1 1997 The IgE/Fc epsilonRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by Fc epsilonRI+ non-B, non-T (NBNT) cells. th2 184-187 interleukin 4 Mus musculus 206-210 34276650-2 2021 Immunopathological mechanisms are well established in the L. (L.) major-mouse model, in which IL-4 instructs a Th2 response towards progressive infection. th2 111-114 interleukin 4 Mus musculus 94-98 34764345-5 2021 In contrast, Th2/Treg related pathways were upregulated as shown by higher expression of IL4 and TGF-beta family genes. th2 13-16 interleukin 4 Mus musculus 89-92 34580637-14 2021 These findings indicate that an increase in IL-4+ CD4+ T cells in the LLN and splenocyte resulted in increased Th2 response to AE exposure. th2 111-114 interleukin 4 Mus musculus 44-48 34580637-15 2021 Exposure of the respiratory system to AE resulted in an increased allergen-induced Th2 inflammatory response and AHR through accumulation of inflammatory and IL-4+ CD4+ T cells and collagen deposition. th2 83-86 interleukin 4 Mus musculus 158-162 34475490-8 2021 There are no statistical differences in nearly all inflammatory markers when compared to their infection-naive CF counterparts, except in the Th2-derived IL-4 and IL-5 which demonstrate significant decreases following exposure (p = 0.046, p = 0.045). th2 142-145 interleukin 4 Mus musculus 154-158 35359977-8 2022 Hence, B cell IL-4 is a major driver of Th2 responses in vivo which promotes allograft survival, and conversely, worsens AAD. th2 40-43 interleukin 4 Mus musculus 14-18 35167596-6 2022 Th2- associated mediators, including arginase, IL-4, and IL-10 are downregulated, while cellular responses are upregulated in line with an increase in the levels of nitric oxide (NO) and interfero-gamma (IFN-gamma). th2 0-3 interleukin 4 Mus musculus 47-51