PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22506851-4	2012	Through the substitution of sulfur for the bridging nitrogen found in clozapine, quetiapine does not directly form a nitrenium ion when incubated with myeloperoxidase/H(2)O(2).	Quetiapine Fumarate	81-91	myeloperoxidase	Homo sapiens	151-166	
35575633-4	2022	The interaction of quetiapine and clozapine with MPO and MPO chlorination activity was studied using UV-vis spectrophotometry.	Quetiapine Fumarate	19-29	myeloperoxidase	Homo sapiens	57-60	
35575633-0	2022	Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite.	Quetiapine Fumarate	55-65	myeloperoxidase	Homo sapiens	11-26	
35575633-2	2022	Neutrophil myeloperoxidase (MPO) metabolism of quetiapine is not well-studied, but is metabolized by cytochrome P450.	Quetiapine Fumarate	47-57	myeloperoxidase	Homo sapiens	11-26	
35575633-2	2022	Neutrophil myeloperoxidase (MPO) metabolism of quetiapine is not well-studied, but is metabolized by cytochrome P450.	Quetiapine Fumarate	47-57	myeloperoxidase	Homo sapiens	28-31	
35575633-3	2022	Based on structural similarity to clozapine, we hypothesized that quetiapine can be metabolized by MPO and that there is overlap between cytochrome P450 and MPO metabolism of quetiapine.	Quetiapine Fumarate	66-76	myeloperoxidase	Homo sapiens	99-102	
35575633-3	2022	Based on structural similarity to clozapine, we hypothesized that quetiapine can be metabolized by MPO and that there is overlap between cytochrome P450 and MPO metabolism of quetiapine.	Quetiapine Fumarate	175-185	myeloperoxidase	Homo sapiens	157-160	
35575633-4	2022	The interaction of quetiapine and clozapine with MPO and MPO chlorination activity was studied using UV-vis spectrophotometry.	Quetiapine Fumarate	19-29	myeloperoxidase	Homo sapiens	49-52	
35575633-6	2022	In the presence of quetiapine, MPO compound II accumulated for about 7.5 min, whereas in the presence of clozapine, MPO compound II was not observed as it was rapidly reduced back to the resting state.	Quetiapine Fumarate	19-29	myeloperoxidase	Homo sapiens	31-34	
35575633-7	2022	Increasing quetiapine concentrations resulted in a decrease in MPO chlorination activity, while the opposite result was found in the case of clozapine.	Quetiapine Fumarate	11-21	myeloperoxidase	Homo sapiens	63-66	
35575633-10	2022	The MPO-catalyzed hydroxylated and dealkylated metabolites of quetiapine and hydroxylated metabolites of clozapine were observed from the LC-MS analyses, particularly when Cl- was included in the reaction.	Quetiapine Fumarate	62-72	myeloperoxidase	Homo sapiens	4-7	
35575633-13	2022	In conclusion, MPO/H2O2/Cl- was shown to metabolize quetiapine to S-oxidation and P450-like dealkylation products, and quetiapine metabolites were generally less reactive than clozapine.	Quetiapine Fumarate	52-62	myeloperoxidase	Homo sapiens	15-18