PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27137148-0 2015 Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment. Quetiapine Fumarate 60-70 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 30-36 27137148-1 2015 The aim of this study was to evaluate whether genetic polymorphisms in CYP3A5 and ABCB1 are responsible for the interindividual variability observed in quetiapine pharmacokinetics. Quetiapine Fumarate 152-162 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 71-77 27137148-3 2015 The single nucleotide polymorphisms (SNPs) evaluated for the genotype effects of quetiapine pharmacokinetics were CYP3A5 A6986G and ABCB1 C3435T, along with other demographic variables and formulations. Quetiapine Fumarate 81-91 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 114-120 25254417-0 2015 Impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on serum concentrations of quetiapine and N-desalkylquetiapine in psychiatric patients. Quetiapine Fumarate 86-96 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 41-47 25254417-1 2015 BACKGROUND: To investigate the impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on steady-state serum concentrations of quetiapine and the active metabolite, N-desalkylquetiapine, in psychiatric patients. Quetiapine Fumarate 130-140 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 72-78 24240480-8 2014 The peak plasma concentration of quetiapine was 208.39 ng/ml for CYP3A5*1/*1, 243.46 ng/ml for CYP3A5*1/*3, and 332.94 ng/ml for CYP3A5*3/*3 (P=0.0118). Quetiapine Fumarate 33-43 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 95-101 24240480-0 2014 Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers. Quetiapine Fumarate 79-89 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 23-29 24240480-2 2014 Quetiapine is metabolized by CYP3A enzymes including CYP3A5 and is a substrate of P-glycoprotein, an efflux drug transporter encoded by the ABCB1 gene. Quetiapine Fumarate 0-10 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 53-59 24240480-7 2014 However, the CYP3A5*3 polymorphism significantly affected the plasma level of quetiapine and its pharmacokinetics. Quetiapine Fumarate 78-88 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 13-19 24240480-8 2014 The peak plasma concentration of quetiapine was 208.39 ng/ml for CYP3A5*1/*1, 243.46 ng/ml for CYP3A5*1/*3, and 332.94 ng/ml for CYP3A5*3/*3 (P=0.0118). Quetiapine Fumarate 33-43 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 65-71 24240480-8 2014 The peak plasma concentration of quetiapine was 208.39 ng/ml for CYP3A5*1/*1, 243.46 ng/ml for CYP3A5*1/*3, and 332.94 ng/ml for CYP3A5*3/*3 (P=0.0118). Quetiapine Fumarate 33-43 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 95-101 24240480-10 2014 CONCLUSION: The results indicated that the genetic polymorphism of CYP3A5*3 but not ABCB1 significantly influences the plasma level of quetiapine and its pharmacokinetics. Quetiapine Fumarate 135-145 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 67-73 24240480-11 2014 These findings suggest that the CYP3A5 genetic polymorphism affects the disposition of quetiapine and provide a plausible explanation for interindividual variation in the disposition of this drug. Quetiapine Fumarate 87-97 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 32-38 15516294-15 2004 Quetiapine is extensively metabolized by CYP 3A4 and CYP 2D6 and to a lesser extent by CYP 3A7, CYP 3A5, and CYP 2C19. Quetiapine Fumarate 0-10 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 96-103 34683865-7 2021 Moreover, CYP3A5 and CYP2B6 phenotypes were related to quetiapine exposure variability, which confirms (for CYP3A5) and suggests (for CYP2B6) that these enzymes play an important role in quetiapine"s metabolism. Quetiapine Fumarate 55-65 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 10-16 34683865-7 2021 Moreover, CYP3A5 and CYP2B6 phenotypes were related to quetiapine exposure variability, which confirms (for CYP3A5) and suggests (for CYP2B6) that these enzymes play an important role in quetiapine"s metabolism. Quetiapine Fumarate 187-197 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 10-16 19022943-0 2009 Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Quetiapine Fumarate 14-24 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 39-45 19022943-2 2009 This in vitro study investigated the relative importance of CYP3A4 and CYP3A5 in the metabolism of quetiapine and compared the metabolic pattern by the two enzymes, in the presence or absence of cytochrome b(5). Quetiapine Fumarate 99-109 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 71-77 19022943-3 2009 Intrinsic clearance (CL(int)) of quetiapine was determined by the substrate depletion approach in CYP3A4 and CYP3A5 insect cell microsomes with or without coexpressed cytochrome b(5). Quetiapine Fumarate 33-43 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 109-115 19022943-5 2009 CL(int) of quetiapine by CYP3A5 was less than 35% relative to CYP3A4. Quetiapine Fumarate 11-21 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 25-31 19022943-7 2009 Metabolism of quetiapine by CYP3A5 revealed a different metabolic pattern compared with CYP3A4. Quetiapine Fumarate 14-24 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 28-34 19022943-9 2009 In conclusion, the present study indicates that CYP3A5 is of minor importance for the overall metabolism of quetiapine, regardless of the presence of cytochrome b(5). Quetiapine Fumarate 108-118 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 48-54 19022943-10 2009 However, a different metabolic pattern by CYP3A5 compared with CYP3A4 could possibly result in different pharmacological and/or toxicological effects of quetiapine in patients expressing CYP3A5. Quetiapine Fumarate 153-163 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 42-48 19022943-10 2009 However, a different metabolic pattern by CYP3A5 compared with CYP3A4 could possibly result in different pharmacological and/or toxicological effects of quetiapine in patients expressing CYP3A5. Quetiapine Fumarate 153-163 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 187-193