PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34683865-0 2021 Variants in COMT, CYP3A5, CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics. Quetiapine Fumarate 50-60 catechol-O-methyltransferase Homo sapiens 12-16 22414277-1 2012 OBJECTIVE: To determine whether polymorphisms of the dopamine D(2) receptor (DRD2) and catechol-O-methyl-transferase (COMT) receptor genes affect the efficacy of quetiapine addition to citalopram in patients with OCD. Quetiapine Fumarate 162-172 catechol-O-methyltransferase Homo sapiens 118-122 34683865-5 2021 The COMT rs13306278 T allele was significantly related to quetiapine-increased exposure. Quetiapine Fumarate 58-68 catechol-O-methyltransferase Homo sapiens 4-8 34683865-6 2021 We demonstrated the existence of quetiapine derivatives with a catechol-like structure (7,8-dihydroxi-quetiapine and 7,8-dihydroxi-N-desalkyl-quetiapine), which would be COMT metabolites and would explain quetiapine accumulation through CYP2D6 and CYP3A4 negative feedback. Quetiapine Fumarate 33-43 catechol-O-methyltransferase Homo sapiens 170-174