PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34683865-0	2021	Variants in COMT, CYP3A5, CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics.	Quetiapine Fumarate	50-60	catechol-O-methyltransferase	Homo sapiens	12-16	
22414277-1	2012	OBJECTIVE: To determine whether polymorphisms of the dopamine D(2) receptor (DRD2) and catechol-O-methyl-transferase (COMT) receptor genes affect the efficacy of quetiapine addition to citalopram in patients with OCD.	Quetiapine Fumarate	162-172	catechol-O-methyltransferase	Homo sapiens	118-122	
34683865-5	2021	The COMT rs13306278 T allele was significantly related to quetiapine-increased exposure.	Quetiapine Fumarate	58-68	catechol-O-methyltransferase	Homo sapiens	4-8	
34683865-6	2021	We demonstrated the existence of quetiapine derivatives with a catechol-like structure (7,8-dihydroxi-quetiapine and 7,8-dihydroxi-N-desalkyl-quetiapine), which would be COMT metabolites and would explain quetiapine accumulation through CYP2D6 and CYP3A4 negative feedback.	Quetiapine Fumarate	33-43	catechol-O-methyltransferase	Homo sapiens	170-174