PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22950911-5	2013	After 8 months of continuous quetiapine administration, memory deficit was reversed and brain Abeta plaque pathology was attenuated in the AD mice.	Quetiapine Fumarate	29-39	amyloid beta (A4) precursor protein	Mus musculus	94-99	
24642954-5	2014	These results suggest that quetiapine can attenuate object recognition memory impairment and brain oxidative stress in an amyloid precursor protein/presenilin-1 transgenic mouse model of AD and indicate that the antioxidative effect of early quetiapine intervention may be associated with the beneficial effect of quetiapine on memory in AD.	Quetiapine Fumarate	27-37	amyloid beta (A4) precursor protein	Mus musculus	122-147	
22950911-6	2013	Quetiapine also decreased the soluble Abeta peptide levels in brain and cerebrospinal fluid (CSF), and attenuated the decreased synaptic protein levels in the AD mice.	Quetiapine Fumarate	0-10	amyloid beta (A4) precursor protein	Mus musculus	38-43	
22950914-3	2013	The present study was designed to examine the effect of chronic administration of quetiapine on the conditioned (generalized) anxiety that is related to learning experience of open arm exposure in the elevated T-maze (ETM) test in an amyloid precursor protein (APP)/presenilin 1 (PS1) double transgenic mouse model of AD.	Quetiapine Fumarate	82-92	amyloid beta (A4) precursor protein	Mus musculus	234-259	
18554300-1	2008	We have shown that quetiapine, a new antipsychotic drug, protects cultured cells against oxidative stress-related cytotoxicities induced by amyloid beta (Abeta)25-35, and that quetiapine prevents memory impairment and decreases Abeta plaques in the brains of amyloid precursor protein (APP)/presenilin-1 (PS-1) double-mutant mice.	Quetiapine Fumarate	19-29	amyloid beta (A4) precursor protein	Mus musculus	154-159	
18554300-1	2008	We have shown that quetiapine, a new antipsychotic drug, protects cultured cells against oxidative stress-related cytotoxicities induced by amyloid beta (Abeta)25-35, and that quetiapine prevents memory impairment and decreases Abeta plaques in the brains of amyloid precursor protein (APP)/presenilin-1 (PS-1) double-mutant mice.	Quetiapine Fumarate	176-186	amyloid beta (A4) precursor protein	Mus musculus	154-159	
18079026-4	2009	After 4 and 7 months of continuous quetiapine administration, memory impairment was prevented, and the number of beta-amyloid (Abeta) plaques decreased in the cortex and hippocampus of the transgenic mice.	Quetiapine Fumarate	35-45	amyloid beta (A4) precursor protein	Mus musculus	127-132	
18079026-5	2009	Quetiapine also decreased brain Abeta peptides, beta-secretase activity and expression, and the level of C99 (an APP C-terminal fragment following cleavage by beta-secretase) in the transgenic mice.	Quetiapine Fumarate	0-10	amyloid beta (A4) precursor protein	Mus musculus	32-37