PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24911389-6	2014	These suggest that quetiapine can attenuate microglia activation in an amyloid precursor protein/presenilin-1 transgenic mouse model of AD, and this may be related to quetiapine"s beneficial effects in AD treatment.	Quetiapine Fumarate	19-29	presenilin 1	Mus musculus	97-109	
22950914-3	2013	The present study was designed to examine the effect of chronic administration of quetiapine on the conditioned (generalized) anxiety that is related to learning experience of open arm exposure in the elevated T-maze (ETM) test in an amyloid precursor protein (APP)/presenilin 1 (PS1) double transgenic mouse model of AD.	Quetiapine Fumarate	82-92	presenilin 1	Mus musculus	266-278	
22950914-3	2013	The present study was designed to examine the effect of chronic administration of quetiapine on the conditioned (generalized) anxiety that is related to learning experience of open arm exposure in the elevated T-maze (ETM) test in an amyloid precursor protein (APP)/presenilin 1 (PS1) double transgenic mouse model of AD.	Quetiapine Fumarate	82-92	presenilin 1	Mus musculus	280-283	
18079026-7	2009	These findings suggest that quetiapine can alleviate cognitive impairment and pathological changes in an APP/PS1 double transgenic mouse model of AD, and further indicate that quetiapine may have preventive effects in the treatment of AD.	Quetiapine Fumarate	28-38	presenilin 1	Mus musculus	109-112	
22950911-8	2013	These results suggest that quetiapine can treat and alleviate the neuropathology in an APP/PS1 transgenic mouse model of AD, and indicate that quetiapine may have therapeutic effects in the treatment of AD.	Quetiapine Fumarate	27-37	presenilin 1	Mus musculus	91-94	
18554300-1	2008	We have shown that quetiapine, a new antipsychotic drug, protects cultured cells against oxidative stress-related cytotoxicities induced by amyloid beta (Abeta)25-35, and that quetiapine prevents memory impairment and decreases Abeta plaques in the brains of amyloid precursor protein (APP)/presenilin-1 (PS-1) double-mutant mice.	Quetiapine Fumarate	19-29	presenilin 1	Mus musculus	291-303	
18554300-1	2008	We have shown that quetiapine, a new antipsychotic drug, protects cultured cells against oxidative stress-related cytotoxicities induced by amyloid beta (Abeta)25-35, and that quetiapine prevents memory impairment and decreases Abeta plaques in the brains of amyloid precursor protein (APP)/presenilin-1 (PS-1) double-mutant mice.	Quetiapine Fumarate	176-186	presenilin 1	Mus musculus	291-303	
25618401-0	2014	Quetiapine attenuates glial activation and proinflammatory cytokines in APP/PS1 transgenic mice via inhibition of nuclear factor-kappaB pathway.	Quetiapine Fumarate	0-10	presenilin 1	Mus musculus	76-79	
25618401-7	2014	RESULTS: Quetiapine improves behavioral performance, marginally affects total Abeta40 and Abeta42 levels, attenuates glial activation, and reduces proinflammatory cytokines in APP/PS1 mice.	Quetiapine Fumarate	9-19	presenilin 1	Mus musculus	180-183	
24911389-6	2014	These suggest that quetiapine can attenuate microglia activation in an amyloid precursor protein/presenilin-1 transgenic mouse model of AD, and this may be related to quetiapine"s beneficial effects in AD treatment.	Quetiapine Fumarate	167-177	presenilin 1	Mus musculus	97-109	
24642954-5	2014	These results suggest that quetiapine can attenuate object recognition memory impairment and brain oxidative stress in an amyloid precursor protein/presenilin-1 transgenic mouse model of AD and indicate that the antioxidative effect of early quetiapine intervention may be associated with the beneficial effect of quetiapine on memory in AD.	Quetiapine Fumarate	27-37	presenilin 1	Mus musculus	148-160