PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30741559-6 2019 PPARgamma-KO mice receiving MWCNT + ESAT-6 had increased granulomas and significantly elevated fibrosis (trichrome staining) compared with wild-type mice or PPARgamma-KO mice that received only MWCNT. mwcnt 28-33 peroxisome proliferator activated receptor gamma Mus musculus 0-9 30741559-8 2019 Analyses of BAL fluid proteins indicated increased levels of transforming growth factor (TGF)-beta and the TGF-beta pathway mediator IL-13 in PPARgamma-KO mice that received MWCNT + ESAT-6 compared with wild-type or PPARgamma-KO mice that received MWCNT. mwcnt 174-179 peroxisome proliferator activated receptor gamma Mus musculus 142-151 29908181-5 2018 Based on these observations we hypothesized that activation of PPARgamma via administration of the PPARgamma-specific ligand rosiglitazone would limit MWCNT-induced granuloma formation and promote PPARgamma-dependent pathways. mwcnt 151-156 peroxisome proliferator activated receptor gamma Mus musculus 63-72 29908181-5 2018 Based on these observations we hypothesized that activation of PPARgamma via administration of the PPARgamma-specific ligand rosiglitazone would limit MWCNT-induced granuloma formation and promote PPARgamma-dependent pathways. mwcnt 151-156 peroxisome proliferator activated receptor gamma Mus musculus 99-108 29908181-5 2018 Based on these observations we hypothesized that activation of PPARgamma via administration of the PPARgamma-specific ligand rosiglitazone would limit MWCNT-induced granuloma formation and promote PPARgamma-dependent pathways. mwcnt 151-156 peroxisome proliferator activated receptor gamma Mus musculus 99-108 23343389-6 2013 Based on such observations we hypothesized that PPARgamma expression would be repressed in alveolar macrophages from animals bearing granulomas induced by MWCNT instillation. mwcnt 155-160 peroxisome proliferator activated receptor gamma Mus musculus 48-57 23343389-9 2013 RESULTS: In wild-type mice, alveolar macrophage PPARgamma expression and activity were significantly reduced in granuloma-bearing animals 60 days after MWCNT instillation. mwcnt 152-157 peroxisome proliferator activated receptor gamma Mus musculus 48-57 23343389-11 2013 PPARgamma KO mice also demonstrated elevated pro-inflammatory cytokine expression in lung tissue, laser-microdissected lung granulomas, and BAL cells/fluids, at 60 days post MWCNT exposure. mwcnt 174-179 peroxisome proliferator activated receptor gamma Mus musculus 0-9