PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33113418-9	2020	Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1beta, IL-6, IL-8 and TNF-alpha.	astaxanthine	47-50	interleukin 6	Homo sapiens	154-158	
26060346-7	2015	Following astaxanthin treatment, localization of nuclear factor kappaB/p65 and the level of inflammatory cytokines (interleukin-6, tumor necrosis factor-alpha) tended to decrease, and cell proliferation significantly increased in vitro.	astaxanthine	10-21	interleukin 6	Homo sapiens	116-158	
32648603-6	2020	AXT also inhibited the induction of COX-2 and IL-6 in human chondrocytes and synovial fibroblasts by western blots.	astaxanthine	0-3	interleukin 6	Homo sapiens	46-50	
25777483-10	2015	Treatment with astaxanthin or withaferin A significantly reduced the increased levels of interleukin-1alpha, interleukin-6/8, granulocyte macrophage stimulatory factor and endothelin-1.	astaxanthine	15-26	interleukin 6	Homo sapiens	109-124	
34557270-6	2021	The effects of astaxanthin on the regulation of cyclooxygenase-2 (COX-2) pathways and the reduction and suppression of cytokines and other inflammatory agents such as IL-6 and TNF-alpha have already been identified.	astaxanthine	15-26	interleukin 6	Homo sapiens	167-171	
20205737-12	2010	There was no difference in TNF and IL-2 concentrations, but plasma IFN-gamma and IL-6 increased on wk 8 in subjects given 8 mg astaxanthin.	astaxanthine	127-138	interleukin 6	Homo sapiens	81-85	
35091276-10	2022	Astaxanthin significantly reduced blood interleukin-6 concentration in T2DM patients (weighted mean difference: -0.70 pg/mL; 95% CI, -1.29 to -0.11 pg/mL; P = .02).	astaxanthine	0-11	interleukin 6	Homo sapiens	40-53	
35038495-6	2022	The astaxanthin-loaded CCs could significantly inhibit the expression of inflammation factors such as interleukin-1beta, interleukin-6, tumor necrosis factor alpha, cyclooxygenase-2, myeloperoxidase, inducible nitric oxide synthase, and nitric oxide.	astaxanthine	4-15	interleukin 6	Homo sapiens	121-134	
33445213-3	2021	Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM.	astaxanthine	61-64	interleukin 6	Homo sapiens	142-146