PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24088727-7	2014	The c-Jun inhibitor SP600125 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells.	pyrazolanthrone	20-28	ATP binding cassette subfamily B member 1	Homo sapiens	117-121	
24333214-0	2014	SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition.	pyrazolanthrone	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	108-112	
25386557-2	2014	RT-PCR and Western blot analysis were used to determine the effects of CH on the expression of MDR1 mRNA and P-glycoprotein in K562/ADR cells when CH was used alone and combined with SP600125, a JNK inhibitor, to explore the effects of CH on JNK pathway.	pyrazolanthrone	183-191	ATP binding cassette subfamily B member 1	Homo sapiens	95-99	
28713943-4	2017	Treatment with the JNK pathway inhibitor, SP600125, at a concentration of 11 microM, decreased the mRNA expression levels of mdr1 and P-gp, as determined using reverse transcription-quantitative polymerase chain reaction and western blot analyses, and similar effects were observed following exposure to ASIV.	pyrazolanthrone	42-50	ATP binding cassette subfamily B member 1	Homo sapiens	125-129	
23983799-6	2013	Moreover, REM promoted phosphorylation of c-Jun NH2-terminal kinase 1/2 (JNK1/2) and JNK1/2 inhibitor, SP600125 and rescued REM inhibition of both MDR1 expression and viabilities in MCF-7/Dox cells.	pyrazolanthrone	103-111	ATP binding cassette subfamily B member 1	Homo sapiens	147-151	
15389514-10	2005	In contrast the JNK inhibitor SP600125 and the ERK1,2 inhibitor UO126 resulted in increase of HIF-1alpha and P-glycoprotein in the control as well as the hyperthermia-treated samples, indicating negative regulation of intrinsic HIF-1alpha and P-glycoprotein expression by ERK1,2 and JNK signaling cascades.	pyrazolanthrone	30-38	ATP binding cassette subfamily B member 1	Homo sapiens	109-123	
15389514-10	2005	In contrast the JNK inhibitor SP600125 and the ERK1,2 inhibitor UO126 resulted in increase of HIF-1alpha and P-glycoprotein in the control as well as the hyperthermia-treated samples, indicating negative regulation of intrinsic HIF-1alpha and P-glycoprotein expression by ERK1,2 and JNK signaling cascades.	pyrazolanthrone	30-38	ATP binding cassette subfamily B member 1	Homo sapiens	243-257	
15604272-6	2004	Furthermore, the JNK inhibitor SP600125 selectively and specifically inhibits hypoxia- and MEKK-1-induced MDR1 promoter activity in a dose-dependent manner.	pyrazolanthrone	31-39	ATP binding cassette subfamily B member 1	Homo sapiens	106-110