PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27008853-5 2016 Additionally, p53 knockout attenuated the apoptosis, and the apoptosis-related protein bax expression and cleaved caspase-3 activation induced by MPE in the p53 knockout C57BL/6 mice, whereas JNK inhibitor SP600125 but not ERK inhibitor U0126 inhibited MPE-induced apoptosis, supporting the conclusion that JNK/p53 might play a critical role in the tubular cell apoptosis induced by MPE and other 3-MCPD fatty acid esters. pyrazolanthrone 206-214 transformation related protein 53, pseudogene Mus musculus 14-17 23429506-12 2013 AG14361 and p53 knockout elicited additive effects with SP600125 on viability in vitro. pyrazolanthrone 56-64 transformation related protein 53, pseudogene Mus musculus 12-15 23533505-6 2013 Inhibition of JNK using pharmacologic inhibitor (SP600125) and genetic knockdown (JNK specific siRNA) significantly inhibited p53 accumulation, reduced PUMA and Fas expression, and abolished apoptosis induced by gallic acid. pyrazolanthrone 49-57 transformation related protein 53, pseudogene Mus musculus 126-129 22353755-6 2012 In this report we showed that intraperitoneal (i.p) injection of JNK-specific inhibitor SP600125 decreased p-JNK level, and reduced PS1 expression by increasing p53 level in adult mouse brains. pyrazolanthrone 88-96 transformation related protein 53, pseudogene Mus musculus 161-164 20955365-9 2011 Knock-down of MKK4 or JNK, or the presence of SP600125 (a JNK inhibitor), each inhibited glutamate-induced p53 activation and GADD45alpha expression. pyrazolanthrone 46-54 transformation related protein 53, pseudogene Mus musculus 107-110