PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24069158-6	2013	In addition, TNF-alpha also stimulated c-Jun and ATF2 phosphorylation which were inhibited by pretreatment with SP600125 and SB202190, respectively, but not PD98059.	pyrazolanthrone	112-120	activating transcription factor 2	Homo sapiens	49-53	
24674138-10	2014	Furthermore, JNK inhibition with SP600125 reduced TGFbeta-induced ATF2 (but not Smad2) phosphorylation and CRP2 protein expression while ROCK inhibition blocked JNK activation.	pyrazolanthrone	33-41	activating transcription factor 2	Homo sapiens	66-70	
15721365-5	2005	Pre-treatment of NS3 protein-expressing cells with JNK inhibitor, SP600125, abolished activation of AP-1 and ATF-2 and inhibited c-jun expression and induced cell growth, suggesting that JNK activation is essential for the stimulation of NS3-mediated cell growth.	pyrazolanthrone	66-74	activating transcription factor 2	Homo sapiens	109-114	
17397142-7	2007	In contrast, the anthrapyrazolone compound, SP600125, exhibited competitive inhibition for ATP and noncompetitive inhibition against ATF2.	pyrazolanthrone	44-52	activating transcription factor 2	Homo sapiens	133-137	
16601071-7	2006	Use of the JNK inhibitor SP600125 or expression of dominant-negative JNK-activator SAPK kinase (SEK1) prevented the induction of ATF2-Thr69+71, but not ATF2-Thr71 phosphorylation by insulin.	pyrazolanthrone	25-33	activating transcription factor 2	Homo sapiens	129-133	
12898508-5	2003	Similarly, inhibition of JNK1 and JNK2 activities by the selective inhibitor SP600125 led to both dose-dependent reduction of c-jun and ATF-2 phosphorylation, and of the differentiation of HL60 cells.	pyrazolanthrone	77-85	activating transcription factor 2	Homo sapiens	136-141	
33806765-5	2021	The inhibition of hypoxia-activated phosphorylation of JNK signal components (JNK, MKK4, nuclear c-Jun and ATF-2) by pre-treatment with SP600125 could suppress hypoxia-stimulated HIF-1alpha upregulation and fibrotic marker proteins expression.	pyrazolanthrone	136-144	activating transcription factor 2	Homo sapiens	107-112