PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22440610-4	2012	IFN-gamma up-regulation was also inhibited by SP600125, indicating that it was downstream of JNK activation.	pyrazolanthrone	46-54	interferon gamma	Homo sapiens	0-9	
15908180-7	2005	This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125.	pyrazolanthrone	207-215	interferon gamma	Homo sapiens	53-62	
19342094-5	2009	To investigate the effectiveness of micelle-incorporated SP600125 in preventing the islet cell death, we challenged the islets with TNF-alpha, IL-1, and IFN gamma.	pyrazolanthrone	57-65	interferon gamma	Homo sapiens	153-162	
18541274-4	2008	Moreover, partial inhibition of AP-1 activity by SP600125, a c-Jun N-terminal kinase (JNK) inhibitor, resulted in marked reduction of IFN-gamma transcription.	pyrazolanthrone	49-57	interferon gamma	Homo sapiens	134-143	
11717429-4	2001	In cells, SP600125 dose dependently inhibited the phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-gamma, TNF-alpha, and prevented the activation and differentiation of primary human CD4 cell cultures.	pyrazolanthrone	10-18	interferon gamma	Homo sapiens	126-135	
15477228-8	2004	Although autologous T cells primed by the ovalbumin (OVA)-pulsed mature DCs produced IFN-gamma, but not IL-4, OVA-pulsed SP600125-treated mature DCs could initiate IL-4 production from autologous T cells.	pyrazolanthrone	121-129	interferon gamma	Homo sapiens	85-94	
15528336-8	2004	We also found that SP600125 interferes with their IFN-gamma response but does not block their cytolytic function.	pyrazolanthrone	19-27	interferon gamma	Homo sapiens	50-59	
15629451-10	2005	IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125.	pyrazolanthrone	271-279	interferon gamma	Homo sapiens	14-23