PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30412649-11	2019	Moreover, the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the Janus-activated kinase (JAK)2 inhibitor AG490 suppressed Ang II-induced differentiation of BM-MSCs into keratinocytes.	pyrazolanthrone	122-130	angiotensinogen	Rattus norvegicus	196-202	
15826947-10	2005	Furthermore, activation of c-Jun NH(2)-terminal kinase (JNK) induced by Ang II stimulation is required for NFAT activation because Ang II-induced NFAT activation was inhibited by SP600125, a selective JNK inhibitor.	pyrazolanthrone	179-187	angiotensinogen	Rattus norvegicus	131-137	
15826947-10	2005	Furthermore, activation of c-Jun NH(2)-terminal kinase (JNK) induced by Ang II stimulation is required for NFAT activation because Ang II-induced NFAT activation was inhibited by SP600125, a selective JNK inhibitor.	pyrazolanthrone	179-187	angiotensinogen	Rattus norvegicus	72-78	
24727493-8	2014	SP-600125 and lactacystin, JNK and NF-kappaB inhibitors, respectively, reduced ANG II-induced ET-1, COX-2, and NOX-1 levels and NOX activity.	pyrazolanthrone	0-9	angiotensinogen	Rattus norvegicus	79-85	
25847782-10	2015	Furthermore, both SB203580 (a specific inhibitor of p38) and SP600125 (JNK1, JNK2 and JNK3 inhibitor) diminished the Ang II-induced production of CTGF; however, the inhibition of FPPS reduced the Ang II-induced activation of p38 mitogen-activated protein kinase (MAPK) and JNK.	pyrazolanthrone	61-69	angiotensinogen	Rattus norvegicus	117-123	
25256260-10	2014	Furthermore, the JNK (SP600125) inhibitor completely blocked Danggui inhibition of caspase-3 activation in Ang II-treated H9c2 cells.	pyrazolanthrone	22-30	angiotensinogen	Rattus norvegicus	107-113	
27306149-6	2016	The specific extracellular signal-regulated kinase inhibitor SP600125 (JNK inhibitor), EGCG (100 muM) and c-Jun N-terminal kinase (JNK) siRNA attenuated endoglin proteins following Ang II induction.	pyrazolanthrone	61-69	angiotensinogen	Rattus norvegicus	181-187	
27306149-9	2016	Finally, EGCG and the JNK inhibitor (SP600125) were found to have attenuated endoglin expression significantly in Ang II-induced CFs, as determined through confocal microscopy.	pyrazolanthrone	37-45	angiotensinogen	Rattus norvegicus	114-120	
22844495-9	2012	Both triterpenes at high doses produced an increase in annexing-V binding in the presence or absence of angiotensin II, which was reduced by either SP600125 or GW9662.	pyrazolanthrone	148-156	angiotensinogen	Rattus norvegicus	104-118	
23277113-8	2013	MAPK kinase 1/2 inhibitor PD98059 and JNK inhibitor SP600125 suppressed Ang II-induced expression of MMP-3 and -13.	pyrazolanthrone	52-60	angiotensinogen	Rattus norvegicus	72-78	
21627650-8	2012	The phosphorylated JNK protein was induced by hypoxia and was abolished by pretreatment with SP600125, losartan (an angiotensin II receptor antagonist) or N-acetylcysteine.	pyrazolanthrone	93-101	angiotensinogen	Rattus norvegicus	116-130	
19752164-5	2011	In the presence of phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin and three individual MAPK inhibitors SB203580, PD98059 and SP600125, both Ang-II-induced cell proliferation and migration were significantly attenuated, although to differing extents, suggesting the PI3K and MAPK signal pathways all participated in regulating rVSMC proliferation and migration.	pyrazolanthrone	136-144	angiotensinogen	Rattus norvegicus	151-157	
21716329-7	2011	Treatment of a p38MAP kinase inhibitor, SB203580 (10 micromol/l), and a JNK inhibitor, SP600125 (20 micromol/l), abrogated the [(3)H]-leucine incorporation by insulin in the presence of Ang II.	pyrazolanthrone	87-95	angiotensinogen	Rattus norvegicus	186-192	
21108934-7	2011	Using both EMSA and chromatin immunoprecipitation (ChIP) analyses, we also showed that Ang II increases binding of GATA4 to DNA, and that this effect is attenuated in the presence of U0126 or SB203580, but not in the presence of SP600125.	pyrazolanthrone	229-237	angiotensinogen	Rattus norvegicus	87-93	
20075153-5	2010	Preincubation with the JNK inhibitor SP600125 (20 micromol/L) slightly inhibited KCl-induced vasoconstriction (Emax: -19%) and markedly inhibited vasoconstriction to NE (-42%), Ang II (-54%), and ET-1 (-42%).	pyrazolanthrone	37-45	angiotensinogen	Rattus norvegicus	177-183	
18158102-6	2008	The JNK inhibitor, SP600125 (10 microM), markedly inhibited Ang II-induced JNK phosphorylation (by 84%) and astrocyte proliferation (by over 90%).	pyrazolanthrone	19-27	angiotensinogen	Rattus norvegicus	60-66	
19286949-7	2009	ANG II-induced AT(1)R expression was blocked by ICV infusion of the p44/42 MAPK inhibitor PD-98059 (0.025 microg/h) and the JNK inhibitor SP-600125 (0.125 microg/h), but not by the p38 MAPK inhibitor SB-203580 (0.125 microg/h).	pyrazolanthrone	138-147	angiotensinogen	Rattus norvegicus	0-6	
17079869-7	2006	U0126, a MEK inhibitor, SP600125, a JNK inhibitor, or SB203580, a p38 inhibitor, attenuates the Ang II-induced [3H]thymidine incorporation into the VSMC.	pyrazolanthrone	24-32	angiotensinogen	Rattus norvegicus	96-102	
16825605-8	2006	Caspase 8 activities induced by ANG II were attenuated by U-0126, SP-600125, and CsA.	pyrazolanthrone	66-75	angiotensinogen	Rattus norvegicus	32-38	
16298339-7	2006	Inhibiting p38MAPK with SB202190 or JNK with SP600125 also reduced angiotensin II-induced alpha-SMA expression.	pyrazolanthrone	45-53	angiotensinogen	Rattus norvegicus	67-81	
16825605-9	2006	DNA fragmentation induced by ANG II was totally blocked by SP-600125, and CsA and was attenuated by U-0126.	pyrazolanthrone	59-68	angiotensinogen	Rattus norvegicus	29-35	
16697003-9	2006	NAC, PD 098059 and SP600125, but not SB202190, also abolished the cardioprotective effect of Ang II preconditioning.	pyrazolanthrone	19-27	angiotensinogen	Rattus norvegicus	93-99	
14755545-13	2004	PD98059, ERK1/2 pathway inhibitor, and SP600125, JNKs inhibitor, partially inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA.	pyrazolanthrone	39-47	angiotensinogen	Rattus norvegicus	85-91	
15921682-7	2005	Ang II-induced Ser307 and Ser616 phophorylation of IRS-1 was inhibited by a MEK inhibitor, PD98059, and a JNK inhibitor, SP600125.	pyrazolanthrone	121-129	angiotensinogen	Rattus norvegicus	0-6	
14755545-14	2004	A combination of PD98059 and SP600125 almost completely inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA.	pyrazolanthrone	29-37	angiotensinogen	Rattus norvegicus	66-72