PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15843470-3	2005	IL-6 production induced by IL-1, TNF-alpha, and IL-17 was specifically inhibited by the c-jun NH(2)-terminal kinase (JNK) inhibitor SP600125, but not by a selective inhibitor of p38 MAPK, and was moderately increased when the ERK1/2 pathway was inhibited.	pyrazolanthrone	132-140	interleukin 1 alpha	Homo sapiens	27-31	
18292576-5	2008	SP600125 reduced the expression of the CRP gene induced by IL-1 plus IL-6.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	59-63	
19800021-6	2010	The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor).	pyrazolanthrone	166-174	interleukin 1 alpha	Homo sapiens	4-8	
15843470-6	2005	Furthermore, IL-1-induced transcriptional activation of the IL-6 promotor was repressed by SP600125 or by co-transfection of a dominant-negative expression plasmid of c-jun even in the absence of a functional AP-1 binding site.	pyrazolanthrone	91-99	interleukin 1 alpha	Homo sapiens	13-17	
34019587-9	2021	Moreover, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) inhibitor U0126, p38 inhibitor SB205380, JNK inhibitor SP600125 and Akt inhibitor GSK 690693 decreased IL-1beta-induced MMP-3 mRNA and protein expression.	pyrazolanthrone	129-137	interleukin 1 alpha	Homo sapiens	177-185	
25598661-7	2014	In addition, treatment with LY294002, SB202190, or SP600125 resulted in significantly attenuated secretion of IL-1alpha.	pyrazolanthrone	51-59	interleukin 1 alpha	Homo sapiens	110-119	
32824426-9	2020	Co-inhibition of ERK and JNK signaling pathways by their specific inhibitors (PD9805 and SP600125, respectively) resulted in the suppression of mRNA and protein levels of IL-6, IL-1beta, and TNFalpha in FLS.	pyrazolanthrone	89-97	interleukin 1 alpha	Homo sapiens	177-185	
29157812-9	2017	Screening of MAP kinase phosphorylation showed a combined activation of IL-1alpha/AKBA on JNK, while the JNK inhibitor SP600125 abolished MMP-9 upregulation induced by IL-1alpha/AKBA.	pyrazolanthrone	119-127	interleukin 1 alpha	Homo sapiens	168-177	
23624146-5	2013	SP600125, an inhibitor of SAPK/JNK, increased the release and the mRNA expression levels of IL-6 induced by IL-1.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	108-112	
23624146-7	2013	SP600125 remarkably suppressed the IL-1-induced phosphorylation of both IkappaB and NF-kappaB, whereas SP600125 failed to affect the IL-1-induced phosphorylation of AMPK, STAT3 or Src.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	35-39	
23624146-9	2013	SP600125 enhanced IL-1-stimulated IL-6 release also in normal human osteoblasts.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	18-22	
21112343-10	2011	Furthermore, JNK was involved in palmitate-induced expression of IL1A, IL8, CXCL3, SPP1 and CEBPB as determined with inhibitor SP600125 (all p<0.05).	pyrazolanthrone	127-135	interleukin 1 alpha	Homo sapiens	65-69