PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17303384-7 2007 LPS-stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha was blocked by helenalin, U0126, SB202190, or SP600125. pyrazolanthrone 138-146 NFKB inhibitor alpha Homo sapiens 78-91 29042991-7 2017 Treatment with extracellular signal-regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-specific inhibitors U0126 and sp600125, respectively, led to the activation of IkappaB-alpha; however, the inhibitor of IkappaBalpha phosphorylation Bay11-7082 did not affect ERK and JNK activity, suggesting that ERK/JNK signaling occurs upstream of NF-kappaB in VECs. pyrazolanthrone 124-132 NFKB inhibitor alpha Homo sapiens 173-186 14647474-7 2003 SP600125 induces NF-kappaB activation in a dose-dependent fashion, associated with phosphorylation of IkappaB kinase alpha (IKKalpha) and degradation of IkappaBalpha. pyrazolanthrone 0-8 NFKB inhibitor alpha Homo sapiens 153-165 15389584-11 2005 Consistently, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha which was blocked by helenalin, U0126, or SP600125. pyrazolanthrone 153-161 NFKB inhibitor alpha Homo sapiens 97-110