PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18713996-12	2008	These results were mimicked by the JNK inhibitor SP600125, indicating that JNK can directly phosphorylate IRF3.	pyrazolanthrone	49-57	interferon regulatory factor 3	Homo sapiens	106-110	
19153595-5	2009	In addition, IRF3-mediated gene expressions on lipopolysaccharide (LPS) or polyinosinic-cytidylic acid (polyI:C) treatment are severely impaired by SP600125, as well as for reporter gene assay of IRF3 activation.	pyrazolanthrone	148-156	interferon regulatory factor 3	Homo sapiens	13-17	
19153595-7	2009	Interestingly, constitutive active IRF3(5D) can be inhibited by SP600125; JNK1 can synergize the action of IRF3(5D), but not the S173A-IRF3(5D) mutant.	pyrazolanthrone	64-72	interferon regulatory factor 3	Homo sapiens	35-39	
19153595-8	2009	More importantly, polyI:C failed to induce the phosphorylation of mutant S173A and SP600125 dramatically abrogated IRF3 phosphorylation and dimerization that was stimulated by polyI:C.	pyrazolanthrone	83-91	interferon regulatory factor 3	Homo sapiens	115-119