PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24406296-9 2014 In addition, inhibiting the JNK and p38 pathways by SP600125 and SB203580 respectively attenuated the LPS-induced apoptosis and regulated the expression of apoptosis-related proteins Bcl-2 and Bax. pyrazolanthrone 52-60 BCL2 associated X, apoptosis regulator Rattus norvegicus 193-196 24969683-5 2014 At the same time, SP600125 attenuated Bax translocation to mitochondria and the release of cytochrome c induced by brain death. pyrazolanthrone 18-26 BCL2 associated X, apoptosis regulator Rattus norvegicus 38-41 23271287-10 2012 The pretreatment of SP600125 or PD98059 could effectively reduce the apoptosis rate by reducing the ratio of Bax/Bcl-2 mRNA levels. pyrazolanthrone 20-28 BCL2 associated X, apoptosis regulator Rattus norvegicus 109-112 24386130-7 2013 Our data showed that pretreatment with luteolin or SP600125 significantly improved the contraction of the isolated heart and cardiomyocytes, reduced infarct size and LDH activity, decreased the rate of apoptosis and increased the Bcl-2/Bax ratio. pyrazolanthrone 51-59 BCL2 associated X, apoptosis regulator Rattus norvegicus 236-239 23064724-13 2012 Intravenous administration of SP600125, a selective phospho-JNK inhibitor (0.5 mg/kg), attenuated HMGB1-dependent Bax translocation and the subsequent apoptosis. pyrazolanthrone 30-38 BCL2 associated X, apoptosis regulator Rattus norvegicus 114-117 27156929-7 2016 Furthermore, in vivo, both of SP600125 (JNK inhibitor) and SB203580 (p38 inhibitor) could decrease the expression of Bax and caspase-3, but increase Bcl-2 levels in HK2 cells treated with iopamidol. pyrazolanthrone 30-38 BCL2 associated X, apoptosis regulator Rattus norvegicus 117-120 22860429-8 2012 CONCLUSION: SP600125 can suppress JNK signal pathway, up-regulate the ratio of Bcl-2/Bax to inhibit Caspase-3 dependent apoptosis, so that it protects lung tissue from ischemia/reperfusion injury. pyrazolanthrone 12-20 BCL2 associated X, apoptosis regulator Rattus norvegicus 85-88 17292878-6 2007 Pretreatment with SP600125 attenuated the bakuchiol-induced translocation of Bax into mitochondria, cytochrome c release into the cytosol, caspase-3 activation, and PARP cleavage. pyrazolanthrone 18-26 BCL2 associated X, apoptosis regulator Rattus norvegicus 77-80 16243436-7 2006 At the same time, SP600125 increased the interaction of Bax with Bcl-2 after 2 days of reperfusion. pyrazolanthrone 18-26 BCL2 associated X, apoptosis regulator Rattus norvegicus 56-59 17568197-8 2007 While in differentiated PC12 cells, the process of apoptosis could only be inhibited effectively by Z-IETD-fmk and SP600125 cotreatment, and SP600125 inhibited the Bax translocation to mitochondria implying that JNK mediated activation of Bax. pyrazolanthrone 141-149 BCL2 associated X, apoptosis regulator Rattus norvegicus 164-167 17568197-8 2007 While in differentiated PC12 cells, the process of apoptosis could only be inhibited effectively by Z-IETD-fmk and SP600125 cotreatment, and SP600125 inhibited the Bax translocation to mitochondria implying that JNK mediated activation of Bax. pyrazolanthrone 141-149 BCL2 associated X, apoptosis regulator Rattus norvegicus 239-242 16674927-4 2006 At the same time, through inhibiting phosphorylation of Bcl-2 and the release of Bax from Bcl-2/Bax dimers, SP600125 attenuated Bax translocation to mitochondria and the release of cytochrome c induced by ischemia/reperfusion (I/R). pyrazolanthrone 108-116 BCL2 associated X, apoptosis regulator Rattus norvegicus 81-84 16674927-4 2006 At the same time, through inhibiting phosphorylation of Bcl-2 and the release of Bax from Bcl-2/Bax dimers, SP600125 attenuated Bax translocation to mitochondria and the release of cytochrome c induced by ischemia/reperfusion (I/R). pyrazolanthrone 108-116 BCL2 associated X, apoptosis regulator Rattus norvegicus 96-99 16674927-4 2006 At the same time, through inhibiting phosphorylation of Bcl-2 and the release of Bax from Bcl-2/Bax dimers, SP600125 attenuated Bax translocation to mitochondria and the release of cytochrome c induced by ischemia/reperfusion (I/R). pyrazolanthrone 108-116 BCL2 associated X, apoptosis regulator Rattus norvegicus 96-99 29745021-7 2018 RESULTS: Fasudil, SB203580, and SP600125 effectively inhibited the HG-induced early apoptosis increase and decreased Bax mRNA expression, the Bax/Bcl-2 protein expression ratio, and cleaved caspase-3 protein levels in the cardiomyocytes; this was accompanied by upregulation of the Bcl-2 mRNA. pyrazolanthrone 32-40 BCL2 associated X, apoptosis regulator Rattus norvegicus 117-120 29745021-7 2018 RESULTS: Fasudil, SB203580, and SP600125 effectively inhibited the HG-induced early apoptosis increase and decreased Bax mRNA expression, the Bax/Bcl-2 protein expression ratio, and cleaved caspase-3 protein levels in the cardiomyocytes; this was accompanied by upregulation of the Bcl-2 mRNA. pyrazolanthrone 32-40 BCL2 associated X, apoptosis regulator Rattus norvegicus 142-145 29559303-9 2018 In addition, RPC increased the phosphorylation of JNK, ERK1/2 and the downstream GSK-3beta, as well as the Bcl-2/Bax ratio, while, these changes were completely reversed by SP600125 and PD98059. pyrazolanthrone 173-181 BCL2 associated X, apoptosis regulator Rattus norvegicus 113-116 27884327-11 2016 Bax was significantly decreased in the SP group. pyrazolanthrone 39-41 BCL2 associated X, apoptosis regulator Rattus norvegicus 0-3 27398138-5 2016 Pretreatment with the SP600125 and Sal A decreased the p-JNK levels and increased the p-Akt levels in diabetic rats with I/R, and heart hemodynamic data improved, infarct size and LDH release decreased, SERCA2a activity increased, Bax and cleaved caspase-3 expression levels decreased, and the expression of Bcl-2 and the Bcl-2/Bax ratio increased. pyrazolanthrone 22-30 BCL2 associated X, apoptosis regulator Rattus norvegicus 231-234 27398138-5 2016 Pretreatment with the SP600125 and Sal A decreased the p-JNK levels and increased the p-Akt levels in diabetic rats with I/R, and heart hemodynamic data improved, infarct size and LDH release decreased, SERCA2a activity increased, Bax and cleaved caspase-3 expression levels decreased, and the expression of Bcl-2 and the Bcl-2/Bax ratio increased. pyrazolanthrone 22-30 BCL2 associated X, apoptosis regulator Rattus norvegicus 328-331