PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	pyrazolanthrone	58-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	142-146	
29273684-7	2018	To explore the mechanism by which SP600125 activates NRF2, mouse mesangial cells (MMCs) were treated with high glucose (HG), in the presence or absence of either SP600125 or JNK siRNA.	pyrazolanthrone	34-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57	
29273684-9	2018	SP600125 inactivated JNK, inhibited kelch-like ECH-associated protein 1 expression, preserved NRF2 protein and facilitated its nuclear translocation in the kidneys of the WT mice, the effects of which were similarly produced by either SP600125 or JNK siRNA in HG-treated MMCs.	pyrazolanthrone	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98	
29273684-11	2018	The present study demonstrates that NRF2 is required for SP600125"s protection against DN.	pyrazolanthrone	57-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-40	
29273684-12	2018	SP600125 activates NRF2 possibly via inhibition of JNK-induced Keap1 expression.	pyrazolanthrone	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23	
29273684-0	2018	SP600125 suppresses Keap1 expression and results in NRF2-mediated prevention of diabetic nephropathy.	pyrazolanthrone	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-56	
29273684-4	2018	We previously reported that SP600125 activated nuclear factor erythroid 2-related factor 2 (NRF2), a governor of the cellular antioxidant defense system, in the aortas of the diabetic mice.	pyrazolanthrone	28-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96	
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	pyrazolanthrone	209-217	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
26066304-7	2015	Pretreatment of C2C12 cells with the JNK inhibitor SP600125 induced a decrease in c-Jun and Nrf2 content and was able to counteract the NaAsO2-mediated increase in CRYAB expression.	pyrazolanthrone	51-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96	
25449124-8	2015	Pretreatment with inhibitors of MAPKs PD98059 (a specific inhibitor of ERK), SP600125 (a specific inhibitor of JNK) abolished both EGB-induced Nrf2 nuclear translocation and HO-1 up-regulation.	pyrazolanthrone	77-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	143-147	
25066549-2	2014	Treatment of RAW264.7 cells with DL increased HO-1 expression in a time- and concentration-dependent manner, and this up-regulation of HO-1 by DL was significantly inhibited by silencing either Nrf2 and p38 or treating cells with SB203580 (a p38MAPK inhibitor), but it was not inhibited in the presence of SP600125 (an ERK inhibitor), PD98059 (a JNK inhibitor), or LY294002 (PI3K inhibitor).	pyrazolanthrone	306-314	nuclear factor, erythroid derived 2, like 2	Mus musculus	194-198	
31945188-5	2020	The JNK inhibitor SP600125 or knockdown of JNK by infection of adenovirus expression JNK siRNA, ameliorated the APAP induced liver toxicity, and inhibited the phosphorylation of Nrf2 and the down-regulation of the detoxifying enzymes by stabilizing the transcription factor.	pyrazolanthrone	18-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182	
32617137-4	2020	Our behavioral, biochemical, and immunofluorescence studies revealed that chronic ischemic injuries sustained increased levels of oxidative stress-induced active JNK for a long time, whereas SP600125 significantly reduced the elevated level of active JNK and further regulated Nrf2/HO-1 and NF-kappaB signaling, which have been confirmed in vivo.	pyrazolanthrone	191-199	nuclear factor, erythroid derived 2, like 2	Mus musculus	277-281