PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25446857-7 2015 Immunoblots showed that the reduction of the Bcl-2/Bax ratio, the induction of caspase 3 cleavage, and the induction of poly(ADP-ribose) polymerase (PARP) cleavage by 6-OHDA was reversed in the presence of SB203580 (a p38 inhibitor) or SP600125 (a JNK inhibitor) in SH-SY5Y cells. pyrazolanthrone 236-244 poly(ADP-ribose) polymerase 1 Homo sapiens 120-147 26287183-5 2015 The anti-Fas blocking antibody reversed the DHTS-induced cell death, and the JNK-specific inhibitor, SP600125, inhibited DHTS-induced caspase-3, -8, -9, and PARP cleavage. pyrazolanthrone 101-109 poly(ADP-ribose) polymerase 1 Homo sapiens 157-161 25530474-8 2015 Furthermore, the specific JNK inhibitor SP600125 blocked chrysotile asbestos-induced JNK activation and subsequent apoptosis, as assessed by both caspase-9 cleavage and PARP activation. pyrazolanthrone 40-48 poly(ADP-ribose) polymerase 1 Homo sapiens 169-173 25446857-7 2015 Immunoblots showed that the reduction of the Bcl-2/Bax ratio, the induction of caspase 3 cleavage, and the induction of poly(ADP-ribose) polymerase (PARP) cleavage by 6-OHDA was reversed in the presence of SB203580 (a p38 inhibitor) or SP600125 (a JNK inhibitor) in SH-SY5Y cells. pyrazolanthrone 236-244 poly(ADP-ribose) polymerase 1 Homo sapiens 149-153 24461294-7 2014 Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells. pyrazolanthrone 81-89 poly(ADP-ribose) polymerase 1 Homo sapiens 130-134 24624962-8 2014 Moreover, JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), indicating that JNK signaling pathway is involved in ZnO NP-induced apoptosis in primary astrocytes. pyrazolanthrone 25-33 poly(ADP-ribose) polymerase 1 Homo sapiens 80-84 19478553-6 2009 Additionally, SP600125- induced delayed apoptosis and cell death was accompanied by significant poly ADP-ribose polymerase (PARP) cleavage and caspase-3 activity in the late phase (at 72 h). pyrazolanthrone 14-22 poly(ADP-ribose) polymerase 1 Homo sapiens 96-122 23982257-11 2013 SP600125 remarkably reduced the expression of cleaved caspase-8, -3, and PARP and the phosphorylation of FADD and c-Jun, as well as apoptotic cell death. pyrazolanthrone 0-8 poly(ADP-ribose) polymerase 1 Homo sapiens 73-77 24333214-2 2014 Using MTS assays, microscopic observation, assessment of cleaved PARP, FACS analysis, and Hoechst staining, we found that the c-Jun N-terminal kinase (Jnk) inhibitor SP600125 (SP) sensitized the antimitotic drug-resistant KBV20C cancer cell line. pyrazolanthrone 166-174 poly(ADP-ribose) polymerase 1 Homo sapiens 65-69 24333214-2 2014 Using MTS assays, microscopic observation, assessment of cleaved PARP, FACS analysis, and Hoechst staining, we found that the c-Jun N-terminal kinase (Jnk) inhibitor SP600125 (SP) sensitized the antimitotic drug-resistant KBV20C cancer cell line. pyrazolanthrone 166-168 poly(ADP-ribose) polymerase 1 Homo sapiens 65-69 24308485-10 2013 Pretreatment with SP600125, U0126, or SB600125 abrogated HymnPro-induced activation of caspases-3 and caspase-7 and the cleavage of PARP, suggesting that MAPK signalings are involved in HymnPro-induced apoptosis. pyrazolanthrone 18-26 poly(ADP-ribose) polymerase 1 Homo sapiens 132-136 19846041-8 2010 SU6656 suppressed Src, JNK, and caspase-3 and -9 activation, as well as PARP and DFF45 cleavage; SP600125 reduced JNK and caspase-3 and -9 activation, as well as PARP and DFF45 cleavage. pyrazolanthrone 97-105 poly(ADP-ribose) polymerase 1 Homo sapiens 162-166 19478553-6 2009 Additionally, SP600125- induced delayed apoptosis and cell death was accompanied by significant poly ADP-ribose polymerase (PARP) cleavage and caspase-3 activity in the late phase (at 72 h). pyrazolanthrone 14-22 poly(ADP-ribose) polymerase 1 Homo sapiens 124-128 16923120-4 2006 In the present study, we demonstrate that an anthrapyrazole SP600125, a reversible ATP-competitive inhibitor of JNK inhibits proliferation of human HMC-1 showed constitutive activation of JNK/c-Jun, and the inhibitory effect of SP600125 on cell proliferation was associated with cell cycle arrest at the G1 phase and apoptosis accompanied by the cleavage of caspase-3 and PARP. pyrazolanthrone 60-68 poly(ADP-ribose) polymerase 1 Homo sapiens 372-376 17371872-9 2007 Pretreatment of MCF7/ADR cells with SP600125, a specific inhibitor of JNK, or with rottlerin, a specific inhibitor of protein kinase Cdelta (PKCdelta), significantly reduced the sangivamycin-induced apoptosis and almost completely abolished sangivamycin-induced phosphorylation of c-Jun and cleavage of lamin A and PARP. pyrazolanthrone 36-44 poly(ADP-ribose) polymerase 1 Homo sapiens 315-319 28087840-6 2017 MAPK inhibitors (SP600125, SB20852, and U0126) suppressed PARP cleavage induced by TNF-alpha/Cholix. pyrazolanthrone 17-25 poly(ADP-ribose) polymerase 1 Homo sapiens 58-62 16151469-6 2005 The phospho-JNK inhibitor SP600125 partially protected Sup-M2 cells from LY293111-induced apoptosis, PARP cleavage and ROS generation, suggesting a role for JNK in LY293111-induced cell death. pyrazolanthrone 26-34 poly(ADP-ribose) polymerase 1 Homo sapiens 101-105 16624850-7 2006 Cells pretreated with SP600125 showed decreases in activation of caspases 9 and 3, decreases in degradation of poly(ADP-ribose) polymerase (PARP), and decreased levels of proapoptotic Bim, in comparison to cells treated with thimerosal alone. pyrazolanthrone 22-30 poly(ADP-ribose) polymerase 1 Homo sapiens 111-138 16624850-7 2006 Cells pretreated with SP600125 showed decreases in activation of caspases 9 and 3, decreases in degradation of poly(ADP-ribose) polymerase (PARP), and decreased levels of proapoptotic Bim, in comparison to cells treated with thimerosal alone. pyrazolanthrone 22-30 poly(ADP-ribose) polymerase 1 Homo sapiens 140-144 27924151-8 2016 Additionally, SP600125- induced delayed apoptosis and cell death was accompanied by significant poly ADP-ribose polymerase (PARP) cleavage and caspase-3 activation in the late phase (at 72 h). pyrazolanthrone 14-22 poly(ADP-ribose) polymerase 1 Homo sapiens 96-122 27924151-8 2016 Additionally, SP600125- induced delayed apoptosis and cell death was accompanied by significant poly ADP-ribose polymerase (PARP) cleavage and caspase-3 activation in the late phase (at 72 h). pyrazolanthrone 14-22 poly(ADP-ribose) polymerase 1 Homo sapiens 124-128 26985944-7 2016 Moreover, both pharmacological JNK inhibitors SP600125 and JNK siRNA dramatically blocked PTX-induced apoptosis, cytochrome c release, caspase 3, and PARP cleavage. pyrazolanthrone 46-54 poly(ADP-ribose) polymerase 1 Homo sapiens 150-154