PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12759338-9 2003 The JNK inhibitor SP600125 antagonized R- and S-flurbiprofen-induced AP-1 DNA binding, suppression of cyclin D1 expression, and the G1-cell cycle block. pyrazolanthrone 18-26 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 69-73 19161988-7 2009 Inhibition of JNK-AP-1 with decoy oligonucleotides to AP-1 or JNK inhibitor SP600125 prevented the decreases in cell viability. pyrazolanthrone 76-84 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 18-22 16277680-10 2005 In addition, inhibition of Cyp7b mRNA expression and activity was observed with SN50, PSI and SP600125, suggesting that NF-kappaB and AP-1 induce Cyp7b transcription. pyrazolanthrone 94-102 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 134-138 20432452-6 2010 IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses. pyrazolanthrone 60-68 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 20-24 20432452-6 2010 IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses. pyrazolanthrone 60-68 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 107-111 18078826-6 2008 Inhibition of AP-1 upstream signaling pathway activators such as JNK by SP600125 suppressed Cyp1a1 mRNA induction by heavy metals, whereas it potentiated their inhibitory effects at the activity level. pyrazolanthrone 72-80 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 14-18 16614379-5 2006 Sulfasalazine was used to inhibit the nuclear factor-kappaB (NFkappaB) pathway and SP600125, a chemical inhibitor of the c-Jun N-terminal kinase, was used as an inhibitor of the activator protein-1 (AP-1) pathway. pyrazolanthrone 83-91 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 178-197 16614379-5 2006 Sulfasalazine was used to inhibit the nuclear factor-kappaB (NFkappaB) pathway and SP600125, a chemical inhibitor of the c-Jun N-terminal kinase, was used as an inhibitor of the activator protein-1 (AP-1) pathway. pyrazolanthrone 83-91 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 199-203 32251709-9 2020 2DP induced phosphorylation of JunB; co-treatment with SP600125 blocked the 2DP-induced Bmp6 expression partially. pyrazolanthrone 55-63 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 31-35 30269025-7 2018 SP600125, a JNK inhibitor, blocked IL-1beta-induced phosphorylation of c-Jun and JunB as well as IL-1beta-induced expression and transcription of hepcidin. pyrazolanthrone 0-8 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 81-85