PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12759338-9	2003	The JNK inhibitor SP600125 antagonized R- and S-flurbiprofen-induced AP-1 DNA binding, suppression of cyclin D1 expression, and the G1-cell cycle block.	pyrazolanthrone	18-26	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-73	
19161988-7	2009	Inhibition of JNK-AP-1 with decoy oligonucleotides to AP-1 or JNK inhibitor SP600125 prevented the decreases in cell viability.	pyrazolanthrone	76-84	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-22	
16277680-10	2005	In addition, inhibition of Cyp7b mRNA expression and activity was observed with SN50, PSI and SP600125, suggesting that NF-kappaB and AP-1 induce Cyp7b transcription.	pyrazolanthrone	94-102	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-138	
20432452-6	2010	IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses.	pyrazolanthrone	60-68	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-24	
20432452-6	2010	IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses.	pyrazolanthrone	60-68	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-111	
18078826-6	2008	Inhibition of AP-1 upstream signaling pathway activators such as JNK by SP600125 suppressed Cyp1a1 mRNA induction by heavy metals, whereas it potentiated their inhibitory effects at the activity level.	pyrazolanthrone	72-80	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18	
16614379-5	2006	Sulfasalazine was used to inhibit the nuclear factor-kappaB (NFkappaB) pathway and SP600125, a chemical inhibitor of the c-Jun N-terminal kinase, was used as an inhibitor of the activator protein-1 (AP-1) pathway.	pyrazolanthrone	83-91	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-197	
16614379-5	2006	Sulfasalazine was used to inhibit the nuclear factor-kappaB (NFkappaB) pathway and SP600125, a chemical inhibitor of the c-Jun N-terminal kinase, was used as an inhibitor of the activator protein-1 (AP-1) pathway.	pyrazolanthrone	83-91	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	199-203	
32251709-9	2020	2DP induced phosphorylation of JunB; co-treatment with SP600125 blocked the 2DP-induced Bmp6 expression partially.	pyrazolanthrone	55-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-35	
30269025-7	2018	SP600125, a JNK inhibitor, blocked IL-1beta-induced phosphorylation of c-Jun and JunB as well as IL-1beta-induced expression and transcription of hepcidin.	pyrazolanthrone	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-85