PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17054427-0	2006	The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells.	pyrazolanthrone	38-46	caspase 8	Homo sapiens	105-114	
17698840-4	2007	In contrast, TRAIL caused increased binding between Mcl-1 and Bak that was diminished by treatment with the caspase 8 inhibitor N-(N(alpha)-acetylisoleucylglutamylthreonyl) aspartic acid (O-methyl ester)-fluoromethyl ketone (IETD(OMe)-fmk) or the c-Jun N-terminal kinase inhibitor SP600125.	pyrazolanthrone	281-289	caspase 8	Homo sapiens	108-117	
17397922-5	2007	Further investigation showed that SP600125 reduced the activation of FasL, caspase-3, caspase-8, and led to a marked decline of p21.	pyrazolanthrone	34-42	caspase 8	Homo sapiens	86-95	
17054427-4	2006	These experiments showed that SP600125 activated caspase 8 and confirmed that D1 activated the intrinsic pathway of apoptosis, as caspase 8 was not affected while Bcl-2 was down-regulated following D1 administration.	pyrazolanthrone	30-38	caspase 8	Homo sapiens	49-58	
16061660-7	2005	SP600125 enhanced cleavage of caspase 3 and caspase 8, the most upstream caspase in the CD95 pathway.	pyrazolanthrone	0-8	caspase 8	Homo sapiens	44-53	
15922728-11	2005	In addition, using SP600125, JNK inhibitor, we demonstrated that CD437 activates the JNK-MAP kinase signaling pathway upstream to mitochondrial and caspase-8 pathways.	pyrazolanthrone	19-27	caspase 8	Homo sapiens	148-157	
15788689-7	2005	The JNK inhibitor SP600125 substantially decreased the activation of caspases and apoptosis induced by MSeA combination with SN38 or etoposide and completely blocked these events induced by MSeA/paclitaxel.	pyrazolanthrone	18-26	caspase 8	Homo sapiens	69-77	
23982257-11	2013	SP600125 remarkably reduced the expression of cleaved caspase-8, -3, and PARP and the phosphorylation of FADD and c-Jun, as well as apoptotic cell death.	pyrazolanthrone	0-8	caspase 8	Homo sapiens	54-63	
15492284-8	2004	Moreover, application of the JNK-specific inhibitor SP600125 blocked CDDO-Me-induced increases in JNK activation, DR up-regulation, caspase-8 activation, and DNA fragmentation.	pyrazolanthrone	52-60	caspase 8	Homo sapiens	132-141	
28542135-6	2017	The specific inhibitors U0126, SP600125 and SB202190 attenuated the expression of MAPKs, and regulated the expression of cleaved caspase-8, -9 and -3.	pyrazolanthrone	31-39	caspase 8	Homo sapiens	129-149	
21138480-7	2011	The caspases activation was inhibited by JNK inhibitor SP600125.	pyrazolanthrone	55-63	caspase 8	Homo sapiens	4-12	
21573233-8	2011	Specific inhibition of p38 with SB203580 did not show any effect whereas inhibition of JNK phosphorylation with SP600125 notably reversed pM-induced cleavage of PARP, caspase-8 and -3, demonstrating a significant role of JNK in pM-induced cell death.	pyrazolanthrone	112-120	caspase 8	Homo sapiens	167-183	
19555659-7	2009	In addition, the selective p38 inhibitor SB203580 and selective JNK inhibitor SP600125 suppressed nano-TiO(2)-induced apoptosis and caspase-8 activation to moderate and significant extents, respectively.	pyrazolanthrone	78-86	caspase 8	Homo sapiens	132-141