PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34448459-9 2021 In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125. pyrazolanthrone 13-21 caspase 3 Rattus norvegicus 112-124 34448459-9 2021 In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125. pyrazolanthrone 178-186 caspase 3 Rattus norvegicus 112-124 29289695-9 2018 SP600125 attenuated isoflurane-induced neuroapoptosis by inhibiting both AIF and caspase-3 pathways and reduced cognitive impairment in neonatal rats. pyrazolanthrone 0-8 caspase 3 Rattus norvegicus 81-90 35119079-8 2022 Moreover, Cyt-c, Caspase-3, JNK and JUN expression levels were detected following treatment with a specific inhibitor of JNK (SP600125). pyrazolanthrone 126-134 caspase 3 Rattus norvegicus 17-26 35119079-9 2022 The results revealed that SP600125 had similar inhibitory effects on the JNK pathway and ERS-related protein expression (Cyt-t, Caspase-3, p-JNK and p-c-JUN). pyrazolanthrone 26-34 caspase 3 Rattus norvegicus 128-137 34237977-7 2021 RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). pyrazolanthrone 94-102 caspase 3 Rattus norvegicus 299-308 24969683-6 2014 Furthermore, the activation of caspase-3 and apoptosis induced by brain death was also significantly suppressed by the administration of SP600125. pyrazolanthrone 137-145 caspase 3 Rattus norvegicus 31-40 27156929-7 2016 Furthermore, in vivo, both of SP600125 (JNK inhibitor) and SB203580 (p38 inhibitor) could decrease the expression of Bax and caspase-3, but increase Bcl-2 levels in HK2 cells treated with iopamidol. pyrazolanthrone 30-38 caspase 3 Rattus norvegicus 125-134 26465378-8 2015 The JNK1/2 inhibitor SP 600125 attenuated PSP-induced caspase-3 and JNK1/2 activation, confirming the role of JNK1/2 in PSP-induced cytotoxicity. pyrazolanthrone 21-30 caspase 3 Rattus norvegicus 54-63 27488855-12 2017 Furthermore, pretreatment with SP600125 (an inhibitor of JNK) diminished the phosphorylation of JNK3 and c-Jun, and further inhibited the activation of caspase-3 after cerebral I/R. pyrazolanthrone 31-39 caspase 3 Rattus norvegicus 152-161 27884327-9 2016 RESULTS: Compared to the IR group and the dimethyl sulfoxide group, the SP group and the H group had larger skin flap survival area, more blood perfusion and lower levels of caspase-3 activity. pyrazolanthrone 72-74 caspase 3 Rattus norvegicus 174-183 19248828-9 2009 Data obtained with SP600125, a selective inhibitor of JNK, revealed that JNK is involved in HNE-induced apoptosis through the inhibition of PARP cleavage and caspase-3 activation in PC12 cells. pyrazolanthrone 19-27 caspase 3 Rattus norvegicus 158-167 25256260-10 2014 Furthermore, the JNK (SP600125) inhibitor completely blocked Danggui inhibition of caspase-3 activation in Ang II-treated H9c2 cells. pyrazolanthrone 22-30 caspase 3 Rattus norvegicus 83-92 21911753-6 2011 Chronic exposure of INS 832/13 cells to glucolipotoxic conditions resulted in increased JNK1/2 phosphorylation and caspase-3 activity; such effects were largely reversed by SP600125, a selective inhibitor of JNK. pyrazolanthrone 173-181 caspase 3 Rattus norvegicus 115-124 24928238-8 2014 SP600125 markedly decreased expressions of p-JNK, p-Nur77, Bcl-2, cyto C, caspase-3 and inhibited apoptosis. pyrazolanthrone 0-8 caspase 3 Rattus norvegicus 74-83 23603260-10 2013 The JNK inhibitor SP600125 dose-dependently inhibited isoflurane-induced neuronal apoptosis and increase of caspase-3 and phospho-JNK. pyrazolanthrone 18-26 caspase 3 Rattus norvegicus 108-117 22860429-8 2012 CONCLUSION: SP600125 can suppress JNK signal pathway, up-regulate the ratio of Bcl-2/Bax to inhibit Caspase-3 dependent apoptosis, so that it protects lung tissue from ischemia/reperfusion injury. pyrazolanthrone 12-20 caspase 3 Rattus norvegicus 100-109 22085843-10 2012 Transfection with ERK2- and JNK-specific si-RNA and specific inhibitors SP600125 and PD98059 could inhibit ERK1/2 and JNK activation and attenuate MMP loss and caspase-3 activity induced by the Cu(2+)/PDTC complex. pyrazolanthrone 72-80 caspase 3 Rattus norvegicus 160-169 20830294-9 2010 Pre-exposure of hepatocytes to a JNK inhibitor SP600125 prevented As-induced caspase-3 activation, ROS production and loss in cell viability. pyrazolanthrone 47-55 caspase 3 Rattus norvegicus 77-86 17292878-6 2007 Pretreatment with SP600125 attenuated the bakuchiol-induced translocation of Bax into mitochondria, cytochrome c release into the cytosol, caspase-3 activation, and PARP cleavage. pyrazolanthrone 18-26 caspase 3 Rattus norvegicus 139-148 15504737-6 2004 JNK inhibition by SP600125 or transfection of dnJNK2 reduced the pool of active JNKs in the nucleus, the release of cytochrome c, as well as the cleavage of caspase-3 and its substrate poly(ADP-ribose) polymerase-1. pyrazolanthrone 18-26 caspase 3 Rattus norvegicus 157-166 16005241-8 2005 Furthermore, inhibition of JNK activity with in vivo delivery of SP600125 or a jnk1 antisense oligodeoxynucleotide (ODN) attenuated DP5 induction and caspase-3 activation. pyrazolanthrone 65-73 caspase 3 Rattus norvegicus 150-159 16787641-7 2006 In contrast, the increase in caspase-3 protein was suppressed by both U0126 and SP600125. pyrazolanthrone 80-88 caspase 3 Rattus norvegicus 29-38 16674927-5 2006 Furthermore, the activation of caspase-3 induced by ischemia/reperfusion was also significantly suppressed by preinfusion of SP600125. pyrazolanthrone 125-133 caspase 3 Rattus norvegicus 31-40 14766793-2 2004 In primary rat hepatocytes expressing an IkappaB superrepressor, the JNK inhibitor SP600125 strongly decreased TNF-alpha-induced cell death, caspase 3 activation, and DNA laddering. pyrazolanthrone 83-91 caspase 3 Rattus norvegicus 141-150 12668975-6 2003 The defective regeneration and the decreased survival in SP600125-treated rats did not result from a major increase in apoptosis as shown by normal levels of caspase 3 activity and only slight increases in apoptotic figures. pyrazolanthrone 57-65 caspase 3 Rattus norvegicus 158-167