PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29766185-11 2018 Moreover, the NAC and JNK inhibitor SP600125 could dramatically reverse WZ35-caused MMP-2, MMP-9, and N-cadherin reduction and E-cadherin up-regulation. pyrazolanthrone 36-44 matrix metallopeptidase 2 Homo sapiens 84-89 31894675-6 2019 Co-treatment with DHM and JNK inhibitor SP600125 further suppressed MMP-2 expression and cell invasion in MKN45 cells, suggesting that DHM inhibited MKN45 cells metastasis through JNK/MMP-2 pathway. pyrazolanthrone 40-48 matrix metallopeptidase 2 Homo sapiens 68-73 31894675-6 2019 Co-treatment with DHM and JNK inhibitor SP600125 further suppressed MMP-2 expression and cell invasion in MKN45 cells, suggesting that DHM inhibited MKN45 cells metastasis through JNK/MMP-2 pathway. pyrazolanthrone 40-48 matrix metallopeptidase 2 Homo sapiens 184-189 25316568-6 2014 Treatment with SP600125 (a JNK inhibitor) or knock-down of JNK1 reduced MMP-2 expression in simvastatin-treated cells. pyrazolanthrone 15-23 matrix metallopeptidase 2 Homo sapiens 72-77 25204501-6 2014 SP600125 (a JNK inhibitor) decreased phosphor-c-Jun and MMP-2 in U2OS-AEG-1, while PD98059 (a ERK1/2 inhibitor) had no influence on the levels of phosphor-c-Jun or MMP-2 in U2OS-AEG-1. pyrazolanthrone 0-8 matrix metallopeptidase 2 Homo sapiens 56-61 23950935-4 2013 MS-enhanced MMP-2 expression and activity were inhibited by molecular inhibition of Akt using Akt siRNA as well as by PI3K/Akt inhibitors, LY293002 and AI, but not by MAPK inhibitors such as PD98059, SP600125 and SB203580. pyrazolanthrone 200-208 matrix metallopeptidase 2 Homo sapiens 12-17 24841706-7 2014 Treatment with SP600125, a JNK inhibitor, attenuated the effects of resveratrol on MMP-2 and MMP-9, and accelerated resveratrol-induced effects on type II collagen, SOX-9 and sulfated proteoglycan production. pyrazolanthrone 15-23 matrix metallopeptidase 2 Homo sapiens 83-88 24510324-6 2014 Furthermore, treating FAK small interfering RNA (FAK siRNA) and specific inhibitor for JNK (SP600125) to AGS cells could reduce the phosphorylation of JNK1/2 and the activity of MMP-2 and MMP-9. pyrazolanthrone 92-100 matrix metallopeptidase 2 Homo sapiens 178-183 21468925-4 2011 The activities of matrix metalloproteinase (MMP)-9 and MMP-2 were increased under hypoxic conditions but treatment with PD98059, SP600125 and SB203580 inhibited their activation in cancer cells, as seen by zymography. pyrazolanthrone 129-137 matrix metallopeptidase 2 Homo sapiens 55-60 23786715-13 2013 Moreover, U0126 and SP600125 abolished the GnRH-II agonist-induced activation of MMP-2. pyrazolanthrone 20-28 matrix metallopeptidase 2 Homo sapiens 81-86 20607722-6 2010 MMP-2 promoter activity and cell invasion were inhibited by p38 mitogen-activated protein kinase (MAPK) siRNA, inhibitor 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridyl)-1H-imidazole (SB203580), and AE, but not by JNK siRNA and inhibitor 1,9-pyrazoloanthrone. pyrazolanthrone 251-271 matrix metallopeptidase 2 Homo sapiens 0-5 20688742-8 2010 The downregulation of MMP-2 expression in CFs by HCE cells was blocked by an inhibitor of signaling by the mitogen-activated protein kinase (MAPK) ERK (PD98059) but was not affected by those of signaling by the MAPKs p38 (SB203580) or JNK (SP600125). pyrazolanthrone 240-248 matrix metallopeptidase 2 Homo sapiens 22-27 20492175-7 2010 Further, the treatment of specific inhibitor for JNK (SP600125) to A549 cells could inhibit TPA-induced MMP-2 and u-PA expressions along with an inhibition on cell invasion and migration. pyrazolanthrone 54-62 matrix metallopeptidase 2 Homo sapiens 104-109 20136087-12 2010 Furthermore, inhibitors specific for JNK (SP600125) reduced expression of MMP-2, MMP-9, and u-PA. pyrazolanthrone 42-50 matrix metallopeptidase 2 Homo sapiens 74-79 19887895-7 2010 Moreover, cholesterol depletion-induced TIMP-2 expression and MMP-2 activation was significantly decreased by MEK inhibitor U0126, and JNK inhibitor SP600125, respectively. pyrazolanthrone 149-157 matrix metallopeptidase 2 Homo sapiens 62-67 19338750-5 2009 Furthermore, Ang II-induced MMP 2 activation was markedly blocked by SP600125, a selective c-Jun N-terminal kinase (JNK) inhibitor, or pre-treatment of cells with antisense oligonucleotide to focal adhesion kinase (FAK), indicating that both molecules were important for the activation of MMP 2 by Ang II receptor stimulation. pyrazolanthrone 69-77 matrix metallopeptidase 2 Homo sapiens 28-33 19633975-7 2010 Further, treating specific inhibitors for PI3K (Wortmannin) or JNK (SP600125) to PC-3 cells could reduce the protein expressions of MMP-2 and MMP-9. pyrazolanthrone 68-76 matrix metallopeptidase 2 Homo sapiens 132-137 16672691-3 2006 The pharmacological actin depolymerization agent cytochalasin D increased expression of MMP-2 and membrane type 1-matrix metalloproteinase (MT1-MMP) mRNA, and this was reduced significantly in the presence of the JNK inhibitor SP600125. pyrazolanthrone 227-235 matrix metallopeptidase 2 Homo sapiens 88-93 19178296-7 2009 Furthermore, the treatment of inhibitors specific for JNK (SP600125) to PC-3 cells could result in a reduced expression of MMP-2, MMP-9, and u-PA. pyrazolanthrone 59-67 matrix metallopeptidase 2 Homo sapiens 123-128 18455449-8 2008 Matrix metalloproteinase-2 (MMP-2) production, and activity also, was reduced in sprout cultures treated with SP600125. pyrazolanthrone 110-118 matrix metallopeptidase 2 Homo sapiens 0-26 18455449-8 2008 Matrix metalloproteinase-2 (MMP-2) production, and activity also, was reduced in sprout cultures treated with SP600125. pyrazolanthrone 110-118 matrix metallopeptidase 2 Homo sapiens 28-33 12909329-6 2003 By zymography, MMP-2 expression was induced by cyclical stretch and was attenuated by TNF-alpha monoclonal antibody and SP600125. pyrazolanthrone 120-128 matrix metallopeptidase 2 Homo sapiens 15-20 16000878-4 2005 Among several signal pathway inhibitors tested, SB203580 and SP600125, which inhibit p38 MAPK and JNK respectively, completely blocked the CD9-stimulated MMP-2 expression. pyrazolanthrone 61-69 matrix metallopeptidase 2 Homo sapiens 154-159 15386367-10 2004 Ethanol activated conventional PKCs and JNKs in fibroblasts; inhibitors of PKC (Go6850 and Go6976) and JNKs (SP600125) significantly inhibited ethanol-mediated MMP-2 activation as well as cell invasion, indicating that PKCs and JNKs play a role in ethanol-induced MMP-2 activation and cell invasion in vitro. pyrazolanthrone 109-117 matrix metallopeptidase 2 Homo sapiens 160-165 15386367-10 2004 Ethanol activated conventional PKCs and JNKs in fibroblasts; inhibitors of PKC (Go6850 and Go6976) and JNKs (SP600125) significantly inhibited ethanol-mediated MMP-2 activation as well as cell invasion, indicating that PKCs and JNKs play a role in ethanol-induced MMP-2 activation and cell invasion in vitro. pyrazolanthrone 109-117 matrix metallopeptidase 2 Homo sapiens 264-269