PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34039740-4 2021 Genetically silencing H6PD blocks NADPH generation, which inhibits the usual reductive directionality of 11beta-HSD1, to effectively replace 11beta-HSD2 function in human-derived cell line models, suppress the concentration of biologically active glucocorticoids in prostate cancer, and reverse enzalutamide resistance in mouse xenograft models. enzalutamide 295-307 2,4-dienoyl-CoA reductase 1 Homo sapiens 34-39