PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35579133-16 2022 On the other hand, enzalutamide may sensitize the cells to doxorubicin through downregulation of the bid/bcl2/mcl1 axis that normally activates the executive caspases, caspase 3/7. enzalutamide 19-31 caspase 3 Homo sapiens 168-179 29109513-9 2017 Enzalutamide decreased Ki67 staining and increased activated caspase3 staining compared with vehicle control in HCC1954 tumors. enzalutamide 0-12 caspase 3 Homo sapiens 61-69 33562646-9 2021 In conclusion, metformin enhances the efficacy of abiraterone and enzalutamide via two PARP-1-dependent, caspase 3-independent pathways, providing a rationale to evaluate these combinations in castration-sensitive PC. enzalutamide 66-78 caspase 3 Homo sapiens 105-114