PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27663589-0 2017 BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer. enzalutamide 51-63 baculoviral IAP repeat containing 6 Homo sapiens 0-5 27663589-8 2017 Molecular pathways associated with growth inhibition were assessed via gene enrichment analysis.Results: Of eight IAPs examined, BIRC6 was the only one showing elevated expression in both enzalutamide-resistant CRPC models. enzalutamide 188-200 baculoviral IAP repeat containing 6 Homo sapiens 129-134 27663589-11 2017 Furthermore, ASO-6w2 inhibited expression of prosurvival genes that were upregulated in the LTL-313BR line.Conclusions:BIRC6 targeting inhibited the growth of enzalutamide-resistant CRPC models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer. enzalutamide 159-171 baculoviral IAP repeat containing 6 Homo sapiens 119-124 27663589-11 2017 Furthermore, ASO-6w2 inhibited expression of prosurvival genes that were upregulated in the LTL-313BR line.Conclusions:BIRC6 targeting inhibited the growth of enzalutamide-resistant CRPC models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer. enzalutamide 261-273 baculoviral IAP repeat containing 6 Homo sapiens 119-124