PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35252694-1 2022 Exploration of alternate solid forms for dasatinib, a potent oncogene tyrosine kinase inhibitor classified under Biopharmaceutics Classification System (BCS) class II drugs with low water solubility and high permeability, has been performed using COSMO-RS excess enthalpy (Hex) to increase dissolution. Dasatinib 41-50 hematopoietically expressed homeobox Homo sapiens 273-276 22874537-0 2012 Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes. Dasatinib 0-9 hematopoietically expressed homeobox Homo sapiens 57-60 22874537-0 2012 Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes. Dasatinib 0-9 hematopoietically expressed homeobox Homo sapiens 61-65 22874537-3 2012 Here we show that the BCR-ABL/Src kinase inhibitor dasatinib decreases PRH phosphorylation and increases PRH-dependent repression of Vegf and Vegfr-1. Dasatinib 51-60 hematopoietically expressed homeobox Homo sapiens 71-74 22874537-3 2012 Here we show that the BCR-ABL/Src kinase inhibitor dasatinib decreases PRH phosphorylation and increases PRH-dependent repression of Vegf and Vegfr-1. Dasatinib 51-60 hematopoietically expressed homeobox Homo sapiens 105-108 22874537-5 2012 Thus the re-establishment of gene control by PRH is in part responsible for the therapeutic effects of dasatinib. Dasatinib 103-112 hematopoietically expressed homeobox Homo sapiens 45-48