PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21663515-0 2011 Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1. Dasatinib 28-37 solute carrier family 22 member 1 Homo sapiens 124-131 18669873-3 2008 (14)C-dasatinib uptake was greater in KCL22-transfected cells with pcDNA3-hOCT1 plasmid (high hOCT1-expressing cells) than in control cells (P = .02). Dasatinib 6-15 solute carrier family 22 member 1 Homo sapiens 74-79 18669873-8 2008 Compared with imatinib, dasatinib achieved superior intracellular levels and BCR-ABL suppression even in cells with low or blocked hOCT1. Dasatinib 24-33 solute carrier family 22 member 1 Homo sapiens 131-136 18669873-10 2008 Dasatinib may therefore offer an advantage over imatinib in patients with low hOCT1 expression. Dasatinib 0-9 solute carrier family 22 member 1 Homo sapiens 78-83 18669873-3 2008 (14)C-dasatinib uptake was greater in KCL22-transfected cells with pcDNA3-hOCT1 plasmid (high hOCT1-expressing cells) than in control cells (P = .02). Dasatinib 6-15 solute carrier family 22 member 1 Homo sapiens 94-99 18669873-5 2008 Dasa-tinib decreased the level of phosphorylated CrkL to 49.9% in control and 40.3% in high hOCT1-expressing cells. Dasatinib 0-10 solute carrier family 22 member 1 Homo sapiens 92-97 18559609-3 2008 The relevance of OCT-1 activity and efflux pumps in determining intracellular uptake and retention (IUR) of dasatinib was assessed. Dasatinib 108-117 solute carrier family 22 member 1 Homo sapiens 17-22 18559609-8 2008 Patients with high OCT-1 activity based on their imatinib uptake had IC50(dasatinib) values equivalent to patients with low OCT-1 activity. Dasatinib 74-83 solute carrier family 22 member 1 Homo sapiens 19-24 25568846-0 2014 OCT-1, ABCB1, and ABCG2 Expression in Imatinib-Resistant Chronic Myeloid Leukemia Treated with Dasatinib or Nilotinib. Dasatinib 95-104 solute carrier family 22 member 1 Homo sapiens 0-5 18398725-7 2008 Uptake of the second generation tyrosine kinase inhibitors, dasatinib and nilotinib, is less dependent upon hOCT1. Dasatinib 60-69 solute carrier family 22 member 1 Homo sapiens 108-113