PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33375770-3 2022 Using a genome-wide CRISPR screen, we identified LZTR1, NF1, TSC1 or TSC2, negative regulators of the MAPK and MTOR pathways, as mediators of sorafenib resistance. Sorafenib 142-151 TSC complex subunit 1 Homo sapiens 61-65 26257239-5 2015 In response to sorafenib treatment, formation of the TSC1/2 complex is enhanced, causing increased phosphorylation of AKT, which contributes to up-regulation of "stemness"-related genes in epithelial cell adhesion molecule-positive cells and enhancement of tumorigenicity. Sorafenib 15-24 TSC complex subunit 1 Homo sapiens 53-57