PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26416459-5 2015 Re-expression of Atg5 restores the lipidation of LC3 and rescues DU145 and MEF atg5-/- cells from sorafenib-induced cell death. Sorafenib 98-107 autophagy related 5 Homo sapiens 17-21 29207150-13 2018 Silencing the key autophagy gene ATG5 using small interfering RNA also increased the anticancer effect of sorafenib. Sorafenib 106-115 autophagy related 5 Homo sapiens 33-37 34203465-7 2021 Both in vitro and in vivo results demonstrated the synergistic effect of the HCQ-sorafenib combination on sorafenib-resistant HCC (Huh7-SR) cells, increasing their sensitivity to treatment by modulating TLR9, autophagy (ATG5 and Beclin-1), oxidative stress (SOD1), and apoptosis (c-caspase3) expression and thus overcoming the drug resistance. Sorafenib 81-90 autophagy related 5 Homo sapiens 220-224 34203465-7 2021 Both in vitro and in vivo results demonstrated the synergistic effect of the HCQ-sorafenib combination on sorafenib-resistant HCC (Huh7-SR) cells, increasing their sensitivity to treatment by modulating TLR9, autophagy (ATG5 and Beclin-1), oxidative stress (SOD1), and apoptosis (c-caspase3) expression and thus overcoming the drug resistance. Sorafenib 106-115 autophagy related 5 Homo sapiens 220-224 29472524-0 2018 PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib. Sorafenib 114-123 autophagy related 5 Homo sapiens 29-33 29472524-8 2018 Our findings show that targeting the PU.1-miR-142-3p-ATG5/ATG16L1 axis may be a useful therapeutic strategy for preventing cyto-protective autophagy to overcome sorafenib resistance. Sorafenib 161-170 autophagy related 5 Homo sapiens 53-57 26416459-11 2015 In summary, the formation of Atg5-deficient autophagosomes in response to sorafenib promotes the interaction of p62 with RIPK leading to cell death by necroptosis. Sorafenib 74-83 autophagy related 5 Homo sapiens 29-33 23468839-12 2013 The AFP-Cre/LoxP-shRNA system target Atg5 gene could significantly sensitize MHCC97L/PLC cells to sorafenib-induced apoptosis in vitro and tumor growth suppression in vivo. Sorafenib 98-107 autophagy related 5 Homo sapiens 37-41 25712526-6 2015 Sorafenib activated autophagy in RCC cells (786-0 and A489 lines), evidenced by p62 degradation, Beclin-1/autophagy protein 5 (ATG-5) upregulation and light chain (LC)3B-I/-II conversion. Sorafenib 0-9 autophagy related 5 Homo sapiens 97-125 25712526-6 2015 Sorafenib activated autophagy in RCC cells (786-0 and A489 lines), evidenced by p62 degradation, Beclin-1/autophagy protein 5 (ATG-5) upregulation and light chain (LC)3B-I/-II conversion. Sorafenib 0-9 autophagy related 5 Homo sapiens 127-132 25712526-10 2015 Meanwhile, knockdown of Beclin-1 or ATG-5 by targeted siRNAs also increased sorafenib-induced cytotoxicity in above RCC cells. Sorafenib 76-85 autophagy related 5 Homo sapiens 36-41 23158184-4 2012 Autophagy protein 5 silencing diminished the antiproliferative effects of sunitinib and sorafenib by 44% (P < .05) and 41% (P < .05), respectively, in medullary thyroid cancer-1.1 cells and by 43% (P < .01) and 39% (P < .05), respectively, in TT cells. Sorafenib 88-97 autophagy related 5 Homo sapiens 0-19 18787411-7 2008 In a CD95-, FADD- and PERK-dependent fashion, sorafenib and vorinostat increased expression of ATG5 that was responsible for enhanced autophagy. Sorafenib 46-55 autophagy related 5 Homo sapiens 95-99 18787411-9 2008 Suppression of PERK function reduced sorafenib and vorinostat lethality whereas suppression of ATG5 levels elevated sorafenib and vorinostat lethality. Sorafenib 116-125 autophagy related 5 Homo sapiens 95-99 18787411-11 2008 Thus sorafenib and vorinostat promote ceramide-dependent CD95 activation followed by induction of multiple downstream survival regulatory signals: ceramide-CD95-PERK-FADD-pro-caspase 8 (death); ceramide-CD95-PERK-eIF2alpha- downward arrowc-FLIP-s (death); ceramide-CD95-PERK-ATG5-autophagy (survival). Sorafenib 5-14 autophagy related 5 Homo sapiens 275-279