PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29948358-1 2018 Sorafenib has been widely used to treat unresectable hepatocellular carcinoma (HCC) but most studies have been done in Child-Pugh A (CP-A) patients with well-preserved liver function. Sorafenib 0-9 carboxypeptidase A1 Homo sapiens 133-137 29188773-10 2017 Mean pharmacokinetic exposure to Sorafenib tosylate 200 mg, Ribavirn and Sofosbuvir at week 8th was 2.1, 1.5,1.2 times greater in CP B than in CP A. Sorafenib 33-42 carboxypeptidase A1 Homo sapiens 143-147 29188773-8 2017 Child pugh score less then 7 (CP A) in adults during treatment phase (received 12 weeks of Sorafenib tosylate 200 mg, Ribavirn and Sofosbuvir 400 mg once daily) have no side effect while child pugh score 7-9 (CP B) have evidence of hypertension. Sorafenib 91-109 carboxypeptidase A1 Homo sapiens 30-34 26029452-11 2015 CONCLUSIONS: Patients with CP-A or CP-B advanced HCC should be offered sorafenib at 400 mg twice daily with optimal management of AEs in order to improve survival. Sorafenib 71-80 carboxypeptidase A1 Homo sapiens 27-31 25789012-3 2015 The present study describes the use of sorafenib in patients with HCC and CP-A or -B cirrhosis. Sorafenib 39-48 carboxypeptidase A1 Homo sapiens 74-84 21883324-9 2011 In the sorafenib group, median OS according to baseline AST was 11.8 (<100 U/L [n = 58]) vs. 3.9 (>=100 U/L [n = 15]) months for CP-A patients (P = 0.127), and 6.5 (<100 U/L [n = 33]) vs. 2.1 (>=100 U/L [n = 21]) months for CP-B patients (P = 0.011). Sorafenib 7-16 carboxypeptidase A1 Homo sapiens 135-139 21883324-11 2011 CONCLUSIONS: Sorafenib was associated with improved survival in both CP-A and CP-B patients. Sorafenib 13-22 carboxypeptidase A1 Homo sapiens 69-73