PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33801653-4 2021 To maintain homeostasis of cellular O-GlcNAcylation, there exists feedback regulation of OGT and OGA expression responding to fluctuations of O-GlcNAc levels; yet, little is known about the molecular mechanisms involved. o-glcnacylation 36-51 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 89-92 33789105-1 2021 Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases. o-glcnacylation 44-59 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 0-3 34785590-1 2021 Aberrant O-GlcNAcylation, a protein posttranslational modification defined by the O-linked attachment of the monosaccharide N-acetylglucosamine (O-GlcNAc), has been implicated in neurodegenerative diseases. o-glcnacylation 9-24 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 109-153 34155345-0 2021 OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP. o-glcnacylation 14-29 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 0-3 34837015-5 2021 Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of O-GlcNAc exerts neuroprotective effects against these diseases. o-glcnacylation 27-42 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 161-169 34391182-0 2021 OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells. o-glcnacylation 14-29 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 0-3 34354953-12 2021 It shunted the glucose flux towards the pentose phosphate pathway (PPP) by activating G6PD through OGT-promoted O-GlcNAcylation. o-glcnacylation 112-127 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 99-102 34354953-13 2021 The expression of OGT was positively correlated with Pol iota expression and O-GlcNAcylation. o-glcnacylation 77-92 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 18-21 34354953-16 2021 In conclusion, Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC. o-glcnacylation 63-78 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 51-54 34712646-4 2021 We also provided evidence that this labeling is dependent on not only the enzymes of OGT responsible for O-GlcNAcylation but also the enzymes of GALT and GALE in the Leloir pathway. o-glcnacylation 105-120 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 85-88 34646384-7 2021 OGT and OGA, unique enzymes that regulate intracellular O-GlcNAcylation, were also indispensable. o-glcnacylation 56-71 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 0-3 34338261-3 2021 This review provides an extensive summary of the recent progress in probing O-GlcNAcylation using mainly chemical methods, with a special focus on discussing mechanistic insights and the structural role of O-GlcNAc at the molecular level. o-glcnacylation 76-91 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 206-214 34441396-2 2021 High levels of O-GlcNAcylation (O-GlcNAc) and pyruvate kinase isoenzyme M2 (PKM2) are associated with malignancy in BC; however, the association with the recurrence risk remains unclear. o-glcnacylation 15-30 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 32-40 30123425-3 2018 O-GlcNAcylation, the attachment of beta-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of intracellular proteins, modulates protein functions and is implicated in cancer pathogenesis. o-glcnacylation 0-15 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 35-69 34135314-1 2021 Accumulated evidence shows that OGT-mediated O-GlcNAcylation plays an important role in response to DNA damage repair. o-glcnacylation 45-60 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 32-35 31373757-6 2019 Combining different approaches on three human colon cell lines (HT29, HCT116 and CCD841CoN), it is herein reported that silencing O-GlcNAc transferase (OGT, the sole enzyme driving O-GlcNAcylation), only slightly affects overall N- and O-glycosylation patterns. o-glcnacylation 181-196 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 130-150 31373757-6 2019 Combining different approaches on three human colon cell lines (HT29, HCT116 and CCD841CoN), it is herein reported that silencing O-GlcNAc transferase (OGT, the sole enzyme driving O-GlcNAcylation), only slightly affects overall N- and O-glycosylation patterns. o-glcnacylation 181-196 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 152-155 34469899-1 2022 Several studies have demonstrated a role of O-GlcNAcylation (O-GlcNAc) in tumorigenesis of various carcinomas by modification of tumor-associated proteins. o-glcnacylation 44-59 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 61-69 33916244-4 2021 We will focus on the complex relationship between phosphorylation and O-GlcNAcylation in the regulation of the RNA Polymerase II (RNAP II) pre-initiation complex and the regulation of the carboxyl-terminal domain of RNAP II via the synchronous actions of OGT, OGA, and kinases. o-glcnacylation 70-85 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 255-258 31373491-3 2019 A single essential enzyme, O-GlcNAc transferase (OGT), is responsible for all nucleocytoplasmic O-GlcNAcylation. o-glcnacylation 96-111 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 27-47 31373491-3 2019 A single essential enzyme, O-GlcNAc transferase (OGT), is responsible for all nucleocytoplasmic O-GlcNAcylation. o-glcnacylation 96-111 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 49-52 30459708-4 2018 A fundamental post-translational modification, named O-GlcNAcylation, depends, inter alia, on these nutrients; it consists to the transfer or the removal of a unique monosaccharide (N-acetyl-D-glucosamine) to a serine or threonine hydroxyl group of nucleocytoplasmic and mitochondrial proteins in a dynamic process by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA), respectively. o-glcnacylation 53-68 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 322-342 30459708-4 2018 A fundamental post-translational modification, named O-GlcNAcylation, depends, inter alia, on these nutrients; it consists to the transfer or the removal of a unique monosaccharide (N-acetyl-D-glucosamine) to a serine or threonine hydroxyl group of nucleocytoplasmic and mitochondrial proteins in a dynamic process by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA), respectively. o-glcnacylation 53-68 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 344-347 28742148-4 2017 O-GlcNAcylation consists in the addition of O-linked-N-acetylglucosamine (O-GlcNAc) on Serine or Threonine residues, a process controlled by two enzymes: O-GlcNAc transferase (OGT), which transfers O-GlcNAc on proteins, and O-GlcNAcase (OGA), which removes it. o-glcnacylation 0-15 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 154-174 29391154-1 2018 O-GlcNAcylation, the addition of beta-N-acetylglucosamine (O-GlcNAc) moiety to Ser/Thr residues, is a sensor of the cell metabolic state. o-glcnacylation 0-15 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 33-67 28624365-3 2017 O-GlcNAcylation is a novel type of O-glycosylation, mediated by O-GlcNAc transferase attaching O-beta-N-acetylglucosamine (O-GlcNAc) to serine/threonine residues of the target proteins. o-glcnacylation 0-15 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 64-131 28742148-4 2017 O-GlcNAcylation consists in the addition of O-linked-N-acetylglucosamine (O-GlcNAc) on Serine or Threonine residues, a process controlled by two enzymes: O-GlcNAc transferase (OGT), which transfers O-GlcNAc on proteins, and O-GlcNAcase (OGA), which removes it. o-glcnacylation 0-15 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 176-179 26640786-4 2015 O-GlcNAc status was assessed by Western blot under normal conditions and after modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease O-GlcNAcylation or O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenyl carbamate (PUGNAc) to increase O-GlcNAcylation. o-glcnacylation 140-155 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 0-8 25627821-6 2015 Augmentation of O-GlcNAcylation with high glucose (33 mM) was associated with diminished basal and maximal cardiomyocyte respiration, a decreased mitochondrial reserve capacity and lower Complex II-dependent respiration (P<0.05); however, pharmacological or genetic modulation of O-GlcNAc modifications under normal or high glucose conditions showed few significant effects on mitochondrial respiration, suggesting that O-GlcNAc does not play a major role in regulating cardiomyocyte mitochondrial function. o-glcnacylation 16-31 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 283-291 27347182-1 2016 O-linked N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation), a dynamic post-translational modification of nuclear and cytoplasmic proteins, may have a critical role in the regulation of biological cell processes and human cancer. o-glcnacylation 55-70 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 30-38 26640786-4 2015 O-GlcNAc status was assessed by Western blot under normal conditions and after modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease O-GlcNAcylation or O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenyl carbamate (PUGNAc) to increase O-GlcNAcylation. o-glcnacylation 251-266 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 0-8 24859566-10 2014 While OGA inhibitors are already being tested for AD treatment, our results provide a strong indication that the general subject of O-GlcNAcylation and specifically its regulation by OGA and OGT in AD need further investigation to conclusively elucidate its potential role in AD pathogenesis and treatment. o-glcnacylation 132-147 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 191-194 23580777-1 2013 O-GlcNAcylation is an inducible, highly dynamic and reversible post-translational modification, mediated by a unique enzyme named O-linked N-acetyl-d-glucosamine (O-GlcNAc) transferase (OGT). o-glcnacylation 0-15 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 186-189