PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34658856-13 2021 Our results predicted that astragalin and rosmarinic acid might regulate the JAK-STAT pathway by targeting PIM2 and STAT1, respectively, while paeoniflorin and rosmarinic acid were likely to regulate inflammatory responses by targeting TNFalpha, IL-6, and IL-4 during T2D. rosmarinic acid 160-175 tumor necrosis factor Mus musculus 236-244 34907739-7 2021 Rosmarinic acid used prior to tumor induction suppressed NF-kappaB, TNF-alpha, vascular endothelial growth factor (VEGF) serum levels, and VEGF receptors. rosmarinic acid 0-15 tumor necrosis factor Mus musculus 68-77 34517734-0 2021 Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-alpha mediated antioxidant effect. rosmarinic acid 0-15 tumor necrosis factor Mus musculus 87-96 34517734-10 2021 With increasing doses of RA, RACK1 and TNF-alpha expression decreased. rosmarinic acid 25-27 tumor necrosis factor Mus musculus 39-48 34517734-12 2021 DISCUSSION AND CONCLUSIONS: Our findings support RA as a hepatoprotective agent to improve APAP-induced ALI and the antioxidant effect mediated through RACK1/TNF-alpha pathway. rosmarinic acid 49-51 tumor necrosis factor Mus musculus 158-167 34250696-13 2021 Rosmarinic acid downregulated the cytokines like interleukin-6, tumor necrosis factor-alpha, interleukin-1beta; inflammatory parameter includes prostaglandin E2 , cyclooxygenase-2, and inducible nitric oxide synthase at a dose-dependently. rosmarinic acid 0-15 tumor necrosis factor Mus musculus 64-91 33712964-6 2021 In addition, transethosomes-in-gel containing RA (RA-TE-Gel) formulations produced a great reduction in the punch edema (P < 0.001) and in TNF-alpha and IL-6 (P < 0.05). rosmarinic acid 46-48 tumor necrosis factor Mus musculus 139-148 33530569-5 2021 RA-loaded nanovesicles improved body weight loss and disease activity index as well as increased mucus production and decreased myeloperoxidase activity and TNF-alpha production. rosmarinic acid 0-2 tumor necrosis factor Mus musculus 157-166 32129352-6 2020 We also found that rosmarinic acid inhibited ethanol-induced mRNA expression of tumor necrosis factor-alpha and interleukin 6. rosmarinic acid 19-34 tumor necrosis factor Mus musculus 80-107 24518541-8 2014 Moreover, RA inhibited the expression of nuclear factor-kappaB (NF-kappaB) and tumor necrosis factor-alpha (TNF-alpha), indicating the inhibition of inflammation. rosmarinic acid 10-12 tumor necrosis factor Mus musculus 79-106 29204872-5 2018 ELISA and qPCR results indicated that RA dose-dependently decreased the expression of TNF-alpha, IL-1beta, and IL-6 both in tissues and mMECs. rosmarinic acid 38-40 tumor necrosis factor Mus musculus 86-95 28840833-10 2017 RA treatments lowered the hepatic level of IL-6, TNF-alpha, and PGE2, as well as the activity of COX-2 (p < 0.05). rosmarinic acid 0-2 tumor necrosis factor Mus musculus 49-58 29131114-6 2017 RESULTS: RA attenuated the expression of the M1 marker iNOS and the levels of proinflammatory factors, including TNF-alpha, IL-1beta, and IL-6; it increased the expression of the M2 marker Arg-1, and inhibited, at least in part, ROS generation and loss of mitochondrial outer membrane permeabilization through the inhibition of cleaved caspase-3 activation. rosmarinic acid 9-11 tumor necrosis factor Mus musculus 113-122 29691532-4 2018 Our results showed that BRAE decreased the histological score and TNF-alpha mRNA expression in a dose-dependent manner, while BRAE + RA dose-dependently attenuated the histological score and mRNA expression of IL-6. rosmarinic acid 25-27 tumor necrosis factor Mus musculus 66-75 24518541-8 2014 Moreover, RA inhibited the expression of nuclear factor-kappaB (NF-kappaB) and tumor necrosis factor-alpha (TNF-alpha), indicating the inhibition of inflammation. rosmarinic acid 10-12 tumor necrosis factor Mus musculus 108-117 22441336-5 2012 RA significantly decreased the production of LPS-induced TNF-a, IL-6, and IL-1beta compare with the LPS group. rosmarinic acid 0-2 tumor necrosis factor Mus musculus 57-62 19295475-2 2009 Results showed that RA concentration dependently down-regulated the levels of TNF-alpha, IL-6, and high-mobility group box 1 protein in LPS-induced RAW264.7 cells, inhibited the IkappaB kinase pathway, and modulated nuclear factor-kappaB. rosmarinic acid 20-22 tumor necrosis factor Mus musculus 78-87 12208367-3 2002 Perilla extract (PE) and rosmarinic acid (RA) treatments significantly reduced the elevation of plasma asparatate aminotransferase levels, as well as anti-TNF and SOD treatment, compared with controls, but this reduction was not seen in the AG group. rosmarinic acid 25-40 tumor necrosis factor Mus musculus 155-158