PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23042518-5	2013	RA also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in mice.	rosmarinic acid	0-2	high mobility group box 1	Mus musculus	18-23	
30880023-8	2019	Furthermore, RA treatment downregulated the expression levels of HMGB1, TLR4 and Myd88 and inhibited NF-kappaB nuclear expression both in PD animal and cell models.	rosmarinic acid	13-15	high mobility group box 1	Mus musculus	65-70	
30880023-9	2019	These findings indicated that RA could attenuate inflammatory responses through suppressing HMGB1/TLR4/NF-kappaB signaling pathway, which may contribute to its anti-PD activity.	rosmarinic acid	30-32	high mobility group box 1	Mus musculus	92-97	
35079027-8	2022	CP activated HMGB1-TLR4/MyD88 axis was also found to be downregulated with the RA treatment.	rosmarinic acid	79-81	high mobility group box 1	Mus musculus	13-18	
30880023-0	2019	Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-kappaB signaling pathway in a mouse model of Parkinson"s disease.	rosmarinic acid	0-15	high mobility group box 1	Mus musculus	69-74	
19295475-2	2009	Results showed that RA concentration dependently down-regulated the levels of TNF-alpha, IL-6, and high-mobility group box 1 protein in LPS-induced RAW264.7 cells, inhibited the IkappaB kinase pathway, and modulated nuclear factor-kappaB.	rosmarinic acid	20-22	high mobility group box 1	Mus musculus	99-124