PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32862580-11	2020	Rosmarinic acid also caused activation of caspase-3 and 9 along with suppressing liver cancer cell migration and invasion.	rosmarinic acid	0-15	caspase 3	Homo sapiens	42-51	
15700781-3	2005	The antiapoptotic effect of RA was further confirmed by increase of mitochondrial membrane potential and inhibition of caspase-3 activity.	rosmarinic acid	28-30	caspase 3	Homo sapiens	119-128	
30453545-10	2018	In addition, RA modulated the protein expression of intrinsic mitochondrial apoptotic pathway-related genes, such as Bax, Bcl-2, caspase-3 and poly (ADP-ribose) polymerase 1 (PARP-1) (cleaved) via the upregulation of p53 derived from HDAC2 downregulation, leading to the increased apoptosis of PC-3 and DU145 cells.	rosmarinic acid	13-15	caspase 3	Homo sapiens	129-173	
30572638-4	2018	Our results showed that both RAE and rosmarinic acid (RA) increased cell viability, decreased the production of reactive oxygen species (ROS), and attenuated high glucose-induced endothelial cells apoptosis in a dose-dependent manner, as evidenced by Hochest staining, Annexin V-FITC/PI double staining, and caspase-3 activity.	rosmarinic acid	37-52	caspase 3	Homo sapiens	308-317	
30572638-4	2018	Our results showed that both RAE and rosmarinic acid (RA) increased cell viability, decreased the production of reactive oxygen species (ROS), and attenuated high glucose-induced endothelial cells apoptosis in a dose-dependent manner, as evidenced by Hochest staining, Annexin V-FITC/PI double staining, and caspase-3 activity.	rosmarinic acid	29-31	caspase 3	Homo sapiens	308-317	
29627902-6	2018	According to the results, it was found that RA and quercetin effectively silenced Hsp27 and both agents induced apoptosis by activating the caspase-3 pathway.	rosmarinic acid	44-46	caspase 3	Homo sapiens	140-149	
29627902-8	2018	For the first time, we reported that rosmarinic acid has the ability to trigger caspase-3 induced apoptosis in human glioma cells.	rosmarinic acid	37-52	caspase 3	Homo sapiens	80-89	
26694802-5	2016	RA induced the increment of p53 levels, caspase-3 activation, and poly-ADP-ribose polymerase cleavage and the reduction of the procaspase-3 and Bcl2.	rosmarinic acid	0-2	caspase 3	Homo sapiens	40-49	
26694802-5	2016	RA induced the increment of p53 levels, caspase-3 activation, and poly-ADP-ribose polymerase cleavage and the reduction of the procaspase-3 and Bcl2.	rosmarinic acid	0-2	caspase 3	Homo sapiens	127-139	
21526214-8	2011	Pretreatment of RA inhibited caspase-1 downstream signal pathway, such as the activation of caspase-3 and 9, release of cytochrome c, translocation of apoptosis-inducing factor, up-regulation of Bax, down-regulation of Bcl-2, generation of reactive oxygen species, and activation of nuclear factor-kappaB.	rosmarinic acid	16-18	caspase 3	Homo sapiens	92-107