PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25380345-0	2015	Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation.	rosmarinic acid	0-15	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	57-62	
33717416-5	2021	RA treatment increased osteoblast differentiation, cell viability and mineralization in MC3T3-E1 osteoblastic cells on Ti surface during differentiation, upregulating Runx-2 and OPG, but downregulating RANKL.	rosmarinic acid	0-2	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	202-207	
33717416-6	2021	This study suggest that RA should be applied as an effective functional and therapeutic substance to enhance osseointegration of osteoblast cells by increasing differentiation, mineralization, and bone formation through the RANKL/RANK/OPG pathway during the differentiation in MC3T3-E1 osteoblastic cells on the Ti surface.	rosmarinic acid	24-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	224-229	
25380345-6	2015	Moreover, rosmarinic acid inhibited not only osteoclast formation in cocultures of mouse bone marrow cells and osteoblasts, but also receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastic differentiation in bone marrow-derived macrophages.	rosmarinic acid	10-25	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	133-184	
25380345-6	2015	Moreover, rosmarinic acid inhibited not only osteoclast formation in cocultures of mouse bone marrow cells and osteoblasts, but also receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastic differentiation in bone marrow-derived macrophages.	rosmarinic acid	10-25	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	186-191	
25380345-7	2015	RANKL-induced p38 mitogen-activated protein kinase and the expression of nuclear factor of activated T cell, c-Jun, and c-Fos were inhibited by rosmarinic acid in bone marrow macrophages.	rosmarinic acid	144-159	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	0-5	
25380345-8	2015	Finally, we confirmed that rosmarinic acid improved bone mass in a soluble RANKL-induced bone loss mouse model.	rosmarinic acid	27-42	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	75-80	
21724708-8	2011	RESULTS: Rosmarinic acid strongly inhibited RANKL-induced NF-kappaB activation and nuclear factor of activated T cells c1 (NFATc1) nuclear translocation in BMM, and also inhibited RANKL-induced formation of TRAP-positive multinucleated cells.	rosmarinic acid	9-24	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	44-49	
21724708-8	2011	RESULTS: Rosmarinic acid strongly inhibited RANKL-induced NF-kappaB activation and nuclear factor of activated T cells c1 (NFATc1) nuclear translocation in BMM, and also inhibited RANKL-induced formation of TRAP-positive multinucleated cells.	rosmarinic acid	9-24	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	180-185	
21724708-10	2011	CONCLUSION: We postulated that rosmarinic acid conferred the inhibitory activity on P. amboinicus for inhibition of osteoclastogenesis via downregulation of RANKL-induced NFATc1 expression.	rosmarinic acid	31-46	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	157-162